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Zfyve28 zinc finger FYVE-type containing 28 [ Rattus norvegicus (Norway rat) ]

Gene ID: 305454, updated on 18-Sep-2024

Summary

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Official Symbol
Zfyve28provided by RGD
Official Full Name
zinc finger FYVE-type containing 28provided by RGD
Primary source
RGD:1310151
See related
EnsemblRapid:ENSRNOG00000014874 AllianceGenome:RGD:1310151
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable phosphatidylinositol-3-phosphate binding activity. Predicted to be involved in negative regulation of epidermal growth factor-activated receptor activity. Predicted to be located in cytosol. Predicted to be active in early endosome membrane. Orthologous to human ZFYVE28 (zinc finger FYVE-type containing 28). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Brain (RPKM 69.7), Thymus (RPKM 8.1) and 2 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Zfyve28 in Genome Data Viewer
Location:
14q21
Exon count:
16
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 14 NC_086032.1 (80692997..80778606)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 14 NC_051349.1 (76468424..76554039)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 14 NC_005113.4 (81725513..81811142)

Chromosome 14 - NC_086032.1Genomic Context describing neighboring genes Neighboring gene cilia and flagella associated protein 99 Neighboring gene ring finger protein 4 Neighboring gene uncharacterized LOC103693090 Neighboring gene uncharacterized LOC120096643 Neighboring gene Max dimerization protein 4

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Monoubiquitinylation regulates endosomal localization of Lst2, a negative regulator of EGF receptor signaling. Mosesson Y, et al. Dev Cell, 2009 May. PMID 19460345, Free PMC Article
  2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables phosphatidylinositol-3-phosphate binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in negative regulation of epidermal growth factor receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in negative regulation of epidermal growth factor receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of epidermal growth factor-activated receptor activity IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of epidermal growth factor-activated receptor activity ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
is_active_in early endosome membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in early endosome membrane ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
lateral signaling target protein 2 homolog
Names
zinc finger, FYVE domain containing 28

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001107227.1 → NP_001100697.1  lateral signaling target protein 2 homolog

    See identical proteins and their annotated locations for NP_001100697.1

    Status: PROVISIONAL

    Source sequence(s)
    CH473963
    UniProtKB/TrEMBL
    A6IK36, D3ZTZ1
    Related
    ENSRNOP00000020154.5, ENSRNOT00000020154.7
    Conserved Domains (1) summary
    cd15731
    Location:828 → 892
    FYVE_LST2; FYVE domain found in lateral signaling target protein 2 homolog (Lst2) and similar proteins

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086032.1 Reference GRCr8

    Range
    80692997..80778606
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006251256.5 → XP_006251318.1  lateral signaling target protein 2 homolog isoform X1

    UniProtKB/TrEMBL
    A0A8I5ZMR3
    Related
    ENSRNOP00000079387.1, ENSRNOT00000107164.2
    Conserved Domains (1) summary
    cd15731
    Location:840 → 904
    FYVE_LST2; FYVE domain found in lateral signaling target protein 2 homolog (Lst2) and similar proteins

  2. XM_006251258.5 → XP_006251320.1  lateral signaling target protein 2 homolog isoform X2

    UniProtKB/TrEMBL
    A0A8I5Y5G8
    Related
    ENSRNOP00000077191.1, ENSRNOT00000094967.2

  3. XM_006251259.5 → XP_006251321.1  lateral signaling target protein 2 homolog isoform X3

    Conserved Domains (1) summary
    pfam05109
    Location:510 → 705
    Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)

RNA

  1. XR_005492958.2 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version

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