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Fam53a family with sequence similarity 53, member A [ Rattus norvegicus (Norway rat) ]

Gene ID: 305461, updated on 17-Aug-2024

Summary

Official Symbol
Fam53aprovided by RGD
Official Full Name
family with sequence similarity 53, member Aprovided by RGD
Primary source
RGD:1563315
See related
EnsemblRapid:ENSRNOG00000017548 AllianceGenome:RGD:1563315
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
RGD1563315
Summary
Predicted to be involved in protein import into nucleus. Predicted to be active in nucleus. Orthologous to human FAM53A (family with sequence similarity 53 member A). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Muscle (RPKM 82.6), Thymus (RPKM 55.6) and 9 other tissues See more
Orthologs
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Genomic context

See Fam53a in Genome Data Viewer
Location:
14q21
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 14 NC_086032.1 (81308127..81348930)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 14 NC_051349.1 (77088178..77124395)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 14 NC_005113.4 (82375086..82416004)

Chromosome 14 - NC_086032.1Genomic Context describing neighboring genes Neighboring gene transforming, acidic coiled-coil containing protein 3 Neighboring gene transmembrane protein 129, E3 ubiquitin ligase Neighboring gene stem-loop histone mRNA binding protein Neighboring gene proteasome 20S subunit beta 3, pseudogene 5 Neighboring gene NK1 homeobox 1

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

General gene information

Markers

Gene Ontology Provided by RGD

Process Evidence Code Pubs
involved_in protein import into nucleus IBA
Inferred from Biological aspect of Ancestor
more info
 
Component Evidence Code Pubs
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
 

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001107228.2NP_001100698.1  protein FAM53A

    See identical proteins and their annotated locations for NP_001100698.1

    Status: PROVISIONAL

    Source sequence(s)
    BC168895
    UniProtKB/TrEMBL
    A6IK61, A6IK62, B5DF22
    Related
    ENSRNOP00000023904.4, ENSRNOT00000023904.7
    Conserved Domains (1) summary
    pfam15242
    Location:1299
    FAM53; Family of FAM53

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086032.1 Reference GRCr8

    Range
    81308127..81348930
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063273161.1XP_063129231.1  protein FAM53A isoform X1

    UniProtKB/TrEMBL
    A6IK61, A6IK62, B5DF22
  2. XM_063273156.1XP_063129226.1  protein FAM53A isoform X1

    UniProtKB/TrEMBL
    A6IK61, A6IK62, B5DF22
  3. XM_063273157.1XP_063129227.1  protein FAM53A isoform X1

    UniProtKB/TrEMBL
    A6IK61, A6IK62, B5DF22
  4. XM_063273155.1XP_063129225.1  protein FAM53A isoform X1

    UniProtKB/TrEMBL
    A6IK61, A6IK62, B5DF22
  5. XM_006251266.5XP_006251328.1  protein FAM53A isoform X1

    See identical proteins and their annotated locations for XP_006251328.1

    UniProtKB/TrEMBL
    A6IK61, A6IK62, B5DF22
    Conserved Domains (1) summary
    pfam15242
    Location:1299
    FAM53; Family of FAM53
  6. XM_063273162.1XP_063129232.1  protein FAM53A isoform X1

    UniProtKB/TrEMBL
    A6IK61, A6IK62, B5DF22
  7. XM_039091983.2XP_038947911.1  protein FAM53A isoform X1

    UniProtKB/TrEMBL
    A6IK61, A6IK62, B5DF22
    Conserved Domains (1) summary
    pfam15242
    Location:1299
    FAM53; Family of FAM53
  8. XM_063273160.1XP_063129230.1  protein FAM53A isoform X1

    UniProtKB/TrEMBL
    A6IK61, A6IK62, B5DF22
  9. XM_063273159.1XP_063129229.1  protein FAM53A isoform X1

    UniProtKB/TrEMBL
    A6IK61, A6IK62, B5DF22
  10. XM_039091982.2XP_038947910.1  protein FAM53A isoform X1

    UniProtKB/TrEMBL
    A6IK61, A6IK62, B5DF22
    Conserved Domains (1) summary
    pfam15242
    Location:1299
    FAM53; Family of FAM53
  11. XM_039091984.2XP_038947912.1  protein FAM53A isoform X2

    Conserved Domains (1) summary
    pfam15242
    Location:1299
    FAM53; Family of FAM53
  12. XM_006251262.5XP_006251324.1  protein FAM53A isoform X1

    See identical proteins and their annotated locations for XP_006251324.1

    UniProtKB/TrEMBL
    A6IK61, A6IK62, B5DF22
    Conserved Domains (1) summary
    pfam15242
    Location:1299
    FAM53; Family of FAM53
  13. XM_063273163.1XP_063129233.1  protein FAM53A isoform X2

  14. XM_006251268.5XP_006251330.1  protein FAM53A isoform X1

    See identical proteins and their annotated locations for XP_006251330.1

    UniProtKB/TrEMBL
    A6IK61, A6IK62, B5DF22
    Conserved Domains (1) summary
    pfam15242
    Location:1299
    FAM53; Family of FAM53
  15. XM_063273164.1XP_063129234.1  protein FAM53A isoform X3