Slc1a4 solute carrier family 1 member 4 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Slc1a4provided by RGD
Official Full Name: solute carrier family 1 member 4provided by RGD
Primary source: RGD:735146
See related: EnsemblRapid:ENSRNOG00000005248 AllianceGenome:RGD:735146
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: ASCT1
Summary: Enables L-serine transmembrane transporter activity. Involved in L-serine transport. Located in dendrite and neuronal cell body. Orthologous to human SLC1A4 (solute carrier family 1 member 4). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Brain (RPKM 71.4), Lung (RPKM 58.8) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 14q22

Exon count:: 9

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	14	NC_086032.1 (98718646..98761672, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	14	NC_051349.1 (94530801..94560190, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	14	NC_005113.4 (104582884..104612417, complement)

Chromosome 14 - NC_086032.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

the selectivity profile of D-serine uptake in cultured rat hippocampal astrocytes is consistent with uptake mediated by both ASCT1 and ASCT2. Together these data suggest that SLC1A4 (ASCT1) may represent an important route of Na-dependent D-serine flux in the brain that has the ability to regulate extracellular D-serine and thereby NMDA receptor activity.
Title: D-Serine Is a Substrate for Neutral Amino Acid Transporters ASCT1/SLC1A4 and ASCT2/SLC1A5, and Is Transported by Both Subtypes in Rat Hippocampal Astrocyte Cultures.
LTD4 inhibits ASCT1 through PKC-mediated phosphorylation of RKIP, leading to the subsequent activation of PKA pathway, possibly through beta2-andrenergic receptor activation.
Title: Protein kinase C-mediated phosphorylation of RKIP regulates inhibition of Na-alanine cotransport by leukotriene D(4) in intestinal epithelial cells.
findings indicate that neurons accumulate a high level of L-serine by using a Na(+)-dependent, high-affinity transport system, operating predominantly through the ASCT1 transporter subtype(ASCT1, SLC1A4).
Title: Characterization of rapid and high-affinity uptake of L-serine in neurons and astrocytes in primary culture.

Submit: New GeneRIF Correction

General gene information

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Markers

Slc1a4 (e-PCR), detects polymorphism
- UniSTS:547317

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables L-alanine transmembrane transporter activity	IBA Inferred from Biological aspect of Ancestor more info
enables L-alanine transmembrane transporter activity	ISO Inferred from Sequence Orthology more info
enables L-aspartate transmembrane transporter activity	IBA Inferred from Biological aspect of Ancestor more info
enables L-aspartate transmembrane transporter activity	ISO Inferred from Sequence Orthology more info
NOT enables L-cystine transmembrane transporter activity	ISO Inferred from Sequence Orthology more info
enables L-cystine transmembrane transporter activity	ISO Inferred from Sequence Orthology more info
enables L-hydroxyproline transmembrane transporter activity	ISO Inferred from Sequence Orthology more info
enables L-proline transmembrane transporter activity	ISO Inferred from Sequence Orthology more info
enables L-serine transmembrane transporter activity	IBA Inferred from Biological aspect of Ancestor more info
enables L-serine transmembrane transporter activity	IDA Inferred from Direct Assay more info	PubMed
enables L-serine transmembrane transporter activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables L-serine transmembrane transporter activity	ISO Inferred from Sequence Orthology more info
enables L-threonine transmembrane transporter activity	IBA Inferred from Biological aspect of Ancestor more info
enables L-threonine transmembrane transporter activity	ISO Inferred from Sequence Orthology more info
enables chloride channel activity	ISO Inferred from Sequence Orthology more info
enables neutral L-amino acid transmembrane transporter activity	ISO Inferred from Sequence Orthology more info
enables symporter activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in L-alanine import across plasma membrane	ISO Inferred from Sequence Orthology more info
involved_in L-alanine transport	ISO Inferred from Sequence Orthology more info
involved_in L-aspartate import across plasma membrane	ISO Inferred from Sequence Orthology more info
NOT involved_in L-cystine transport	ISO Inferred from Sequence Orthology more info
involved_in L-cystine transport	ISO Inferred from Sequence Orthology more info
involved_in L-glutamate transmembrane transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in L-serine import across plasma membrane	ISO Inferred from Sequence Orthology more info
involved_in L-serine transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in L-serine transport	IDA Inferred from Direct Assay more info	PubMed
involved_in L-serine transport	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in L-serine transport	ISO Inferred from Sequence Orthology more info
involved_in chloride transmembrane transport	IEA Inferred from Electronic Annotation more info
involved_in cognition	ISO Inferred from Sequence Orthology more info
involved_in hydroxyproline transport	ISO Inferred from Sequence Orthology more info
involved_in proline transmembrane transport	IEA Inferred from Electronic Annotation more info
involved_in proline transport	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within serine import across plasma membrane	ISO Inferred from Sequence Orthology more info
involved_in threonine transport	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in centrosome	ISO Inferred from Sequence Orthology more info
located_in dendrite	IDA Inferred from Direct Assay more info	PubMed
located_in intermediate filament	ISO Inferred from Sequence Orthology more info
located_in membrane	ISO Inferred from Sequence Orthology more info
located_in neuronal cell body	IDA Inferred from Direct Assay more info	PubMed
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
is_active_in plasma membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: neutral amino acid transporter A

Names: neutral amino acid transporter ASCT1; solute carrier family 1 (glutamate/neutral amino acid transporter), member 4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.