U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Aftph aftiphilin [ Rattus norvegicus (Norway rat) ]

Gene ID: 305544, updated on 2-Nov-2024

Summary

Go to the top of the page Help
Official Symbol
Aftphprovided by RGD
Official Full Name
aftiphilinprovided by RGD
Primary source
RGD:1311920
See related
EnsemblRapid:ENSRNOG00000005411 AllianceGenome:RGD:1311920
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
RGD1311920
Summary
Predicted to enable clathrin binding activity. Predicted to be involved in intracellular transport. Predicted to be located in Golgi apparatus; cytosol; and nucleoplasm. Predicted to be part of AP-1 adaptor complex. Predicted to be active in trans-Golgi network membrane. Orthologous to human AFTPH (aftiphilin). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Kidney (RPKM 370.1), Thymus (RPKM 259.4) and 9 other tissues See more
Orthologs
human mouse all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See Aftph in Genome Data Viewer
Location:
14q22
Exon count:
12
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 14 NC_086032.1 (99072761..99127006, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 14 NC_051349.1 (94871429..94925625, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 14 NC_005113.4 (104921633..104975763, complement)

Chromosome 14 - NC_086032.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134481873 Neighboring gene SERTA domain containing 2 Neighboring gene ribosomal protein S28, pseudogene 5 Neighboring gene uncharacterized LOC102548772 Neighboring gene galectin-like

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. The aftiphilin/p200/gamma-synergin complex. Hirst J, et al. Mol Biol Cell, 2005 May. PMID 15758025, Free PMC Article
  2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

Go to the top of the page Help

Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables clathrin binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables clathrin binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in intracellular transport IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
part_of AP-1 adaptor complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of AP-1 adaptor complex ISO
Inferred from Sequence Orthology
more info
  
located_in Golgi apparatus ISO
Inferred from Sequence Orthology
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in intracellular membrane-bounded organelle ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
is_active_in trans-Golgi network membrane IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

Go to the top of the page Help
Preferred Names
aftiphilin

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001305127.1 → NP_001292056.1  aftiphilin

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000014
    UniProtKB/TrEMBL
    A6JQ26
    Related
    ENSRNOP00000053783.3, ENSRNOT00000056944.7
    Conserved Domains (1) summary
    pfam15045
    Location:696 → 765
    Clathrin_bdg; Clathrin-binding box of Aftiphilin, vesicle trafficking

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086032.1 Reference GRCr8

    Range
    99072761..99127006 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006251532.5 → XP_006251594.1  aftiphilin isoform X1

    See identical proteins and their annotated locations for XP_006251594.1

    UniProtKB/TrEMBL
    A6JQ26, D3ZQQ1
    Related
    ENSRNOP00000082054.2, ENSRNOT00000103613.2
    Conserved Domains (2) summary
    pfam15045
    Location:696 → 765
    Clathrin_bdg; Clathrin-binding box of Aftiphilin, vesicle trafficking
    NF033845
    Location:366 → 611
    MSCRAMM_ClfB; MSCRAMM family adhesin clumping factor ClfB

  2. XM_039092071.2 → XP_038947999.1  aftiphilin isoform X4

    UniProtKB/TrEMBL
    A0A8I6A421, A6JQ26
    Conserved Domains (2) summary
    pfam15045
    Location:696 → 758
    Clathrin_bdg; Clathrin-binding box of Aftiphilin, vesicle trafficking
    NF033845
    Location:366 → 611
    MSCRAMM_ClfB; MSCRAMM family adhesin clumping factor ClfB

  3. XM_039092070.2 → XP_038947998.1  aftiphilin isoform X3

    UniProtKB/TrEMBL
    A6JQ26
    Related
    ENSRNOP00000085437.2, ENSRNOT00000103072.2
    Conserved Domains (2) summary
    pfam15045
    Location:696 → 758
    Clathrin_bdg; Clathrin-binding box of Aftiphilin, vesicle trafficking
    NF033845
    Location:366 → 611
    MSCRAMM_ClfB; MSCRAMM family adhesin clumping factor ClfB

  4. XM_039092069.2 → XP_038947997.1  aftiphilin isoform X1

    UniProtKB/TrEMBL
    A6JQ26, D3ZQQ1
    Conserved Domains (2) summary
    pfam15045
    Location:696 → 765
    Clathrin_bdg; Clathrin-binding box of Aftiphilin, vesicle trafficking
    NF033845
    Location:366 → 611
    MSCRAMM_ClfB; MSCRAMM family adhesin clumping factor ClfB

  5. XM_039092068.2 → XP_038947996.1  aftiphilin isoform X1

    UniProtKB/TrEMBL
    A6JQ26, D3ZQQ1
    Conserved Domains (2) summary
    pfam15045
    Location:696 → 765
    Clathrin_bdg; Clathrin-binding box of Aftiphilin, vesicle trafficking
    NF033845
    Location:366 → 611
    MSCRAMM_ClfB; MSCRAMM family adhesin clumping factor ClfB

  6. XM_063273238.1 → XP_063129308.1  aftiphilin isoform X2

  7. XM_063273237.1 → XP_063129307.1  aftiphilin isoform X2

RNA

  1. XR_005492976.2 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
Molecular Biology Databases
Research Materials
Tools