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Wdpcp WD repeat containing planar cell polarity effector [ Rattus norvegicus (Norway rat) ]

Gene ID: 305552, updated on 2-Nov-2024

Summary

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Official Symbol
Wdpcpprovided by RGD
Official Full Name
WD repeat containing planar cell polarity effectorprovided by RGD
Primary source
RGD:1309501
See related
EnsemblRapid:ENSRNOG00000054331 AllianceGenome:RGD:1309501
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
RGD1309501
Summary
Predicted to enable phosphatidylinositol binding activity. Predicted to be involved in several processes, including cilium assembly; regulation of embryonic cell shape; and septin cytoskeleton organization. Predicted to act upstream of or within several processes, including embryonic digit morphogenesis; podocyte cell migration; and sensory organ morphogenesis. Predicted to be located in apical plasma membrane; axoneme; and cell cortex. Predicted to be active in axonemal basal plate. Human ortholog(s) of this gene implicated in Bardet-Biedl syndrome 15 and congenital heart defects, hamartomas of tongue, and polysyndactyly. Orthologous to human WDPCP (WD repeat containing planar cell polarity effector). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Thymus (RPKM 53.9), Lung (RPKM 48.0) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Wdpcp in Genome Data Viewer
Location:
14q22
Exon count:
27
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 14 NC_086032.1 (99847463..100178392)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 14 NC_051349.1 (95645955..95977120)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 14 NC_005113.4 (106393959..106759511)

Chromosome 14 - NC_086032.1Genomic Context describing neighboring genes Neighboring gene large ribosomal subunit protein eL21-like Neighboring gene malate dehydrogenase 1 Neighboring gene small nucleolar RNA SNORA19 Neighboring gene uncharacterized LOC134481800 Neighboring gene collagen alpha-1(III) chain-like Neighboring gene orthodenticle homeobox 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. The ciliopathy-associated CPLANE proteins direct basal body recruitment of intraflagellar transport machinery. Toriyama M, et al. Nat Genet, 2016 Jun. PMID 27158779, Free PMC Article
  2. Wdpcp, a PCP protein required for ciliogenesis, regulates directional cell migration and cell polarity by direct modulation of the actin cytoskeleton. Cui C, et al. PLoS Biol, 2013 Nov. PMID 24302887, Free PMC Article
  3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
  4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables phosphatidylinositol binding IEA
Inferred from Electronic Annotation
more info
  
enables phosphatidylinositol binding ISS
Inferred from Sequence or Structural Similarity
more info
  
Process Evidence Code Pubs
involved_in auditory receptor cell morphogenesis IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within auditory receptor cell morphogenesis ISO
Inferred from Sequence Orthology
more info
  
involved_in camera-type eye development IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within camera-type eye development ISO
Inferred from Sequence Orthology
more info
  
involved_in cell projection organization IEA
Inferred from Electronic Annotation
more info
  
involved_in cilium assembly IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within cilium assembly ISO
Inferred from Sequence Orthology
more info
  
involved_in cilium assembly ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in cilium organization IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within cilium organization ISO
Inferred from Sequence Orthology
more info
  
involved_in circulatory system development IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within circulatory system development ISO
Inferred from Sequence Orthology
more info
  
involved_in digestive system development IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within digestive system development ISO
Inferred from Sequence Orthology
more info
  
involved_in embryonic digit morphogenesis IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within embryonic digit morphogenesis ISO
Inferred from Sequence Orthology
more info
  
involved_in embryonic digit morphogenesis ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within embryonic organ development ISO
Inferred from Sequence Orthology
more info
  
involved_in establishment of protein localization IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in establishment of protein localization IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within establishment of protein localization ISO
Inferred from Sequence Orthology
more info
  
involved_in kidney development IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within kidney development ISO
Inferred from Sequence Orthology
more info
  
involved_in nervous system development IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within nervous system development ISO
Inferred from Sequence Orthology
more info
  
involved_in podocyte cell migration IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within podocyte cell migration ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of embryonic cell shape ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in regulation of establishment of cell polarity IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within regulation of establishment of cell polarity ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of fibroblast migration IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within regulation of fibroblast migration ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of focal adhesion assembly IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within regulation of focal adhesion assembly ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of protein localization ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in regulation of ruffle assembly IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within regulation of ruffle assembly ISO
Inferred from Sequence Orthology
more info
  
involved_in respiratory system development IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within respiratory system development ISO
Inferred from Sequence Orthology
more info
  
involved_in roof of mouth development IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within roof of mouth development ISO
Inferred from Sequence Orthology
more info
  
involved_in roof of mouth development ISO
Inferred from Sequence Orthology
more info
  
involved_in septin cytoskeleton organization ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in smoothened signaling pathway IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within smoothened signaling pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in tongue morphogenesis IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within tongue morphogenesis ISO
Inferred from Sequence Orthology
more info
  
involved_in tongue morphogenesis ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in apical plasma membrane ISS
Inferred from Sequence or Structural Similarity
more info
  
is_active_in axonemal basal plate IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in axonemal basal plate IEA
Inferred from Electronic Annotation
more info
  
located_in axonemal basal plate ISO
Inferred from Sequence Orthology
more info
  
located_in axoneme ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in cell cortex ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in cilium IEA
Inferred from Electronic Annotation
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
WD repeat-containing and planar cell polarity effector protein fritz homolog

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001127537.1 → NP_001121009.1  WD repeat-containing and planar cell polarity effector protein fritz homolog

    See identical proteins and their annotated locations for NP_001121009.1

    Status: PROVISIONAL

    Source sequence(s)
    BC161962
    UniProtKB/Swiss-Prot
    B1WC10
    UniProtKB/TrEMBL
    A0A0G2JXB0
    Related
    ENSRNOP00000070201.2, ENSRNOT00000092168.3
    Conserved Domains (2) summary
    pfam11768
    Location:48 → 591
    DUF3312; Protein of unknown function (DUF3312)
    sd00039
    Location:310 → 345
    7WD40; WD40 repeat [structural motif]

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086032.1 Reference GRCr8

    Range
    99847463..100178392
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039092074.2 → XP_038948002.1  WD repeat-containing and planar cell polarity effector protein fritz homolog isoform X1

    UniProtKB/TrEMBL
    A0A0G2JXB0
    Conserved Domains (2) summary
    sd00039
    Location:330 → 365
    7WD40; WD40 repeat [structural motif]
    pfam11768
    Location:68 → 664
    Frtz; WD repeat-containing and planar cell polarity effector protein Fritz

  2. XM_063273244.1 → XP_063129314.1  WD repeat-containing and planar cell polarity effector protein fritz homolog isoform X3

  3. XM_039092078.2 → XP_038948006.1  WD repeat-containing and planar cell polarity effector protein fritz homolog isoform X4

    UniProtKB/TrEMBL
    A0A0G2JXB0, A0A8I5Y2A3
    Related
    ENSRNOP00000078004.2, ENSRNOT00000101695.2
    Conserved Domains (2) summary
    sd00039
    Location:330 → 365
    7WD40; WD40 repeat [structural motif]
    pfam11768
    Location:68 → 611
    Frtz; WD repeat-containing and planar cell polarity effector protein Fritz

  4. XM_063273245.1 → XP_063129315.1  WD repeat-containing and planar cell polarity effector protein fritz homolog isoform X5

  5. XM_063273247.1 → XP_063129317.1  WD repeat-containing and planar cell polarity effector protein fritz homolog isoform X8

  6. XM_063273249.1 → XP_063129319.1  WD repeat-containing and planar cell polarity effector protein fritz homolog isoform X10

    Related
    ENSRNOP00000090509.2, ENSRNOT00000107912.2

  7. XM_039092085.2 → XP_038948013.1  WD repeat-containing and planar cell polarity effector protein fritz homolog isoform X11

    Conserved Domains (2) summary
    sd00039
    Location:330 → 365
    7WD40; WD40 repeat [structural motif]
    pfam11768
    Location:68 → 544
    Frtz; WD repeat-containing and planar cell polarity effector protein Fritz

  8. XM_063273246.1 → XP_063129316.1  WD repeat-containing and planar cell polarity effector protein fritz homolog isoform X7

  9. XM_039092081.2 → XP_038948009.1  WD repeat-containing and planar cell polarity effector protein fritz homolog isoform X6

    UniProtKB/TrEMBL
    A0A0G2JXB0
    Conserved Domains (2) summary
    sd00039
    Location:231 → 266
    7WD40; WD40 repeat [structural motif]
    pfam11768
    Location:1 → 565
    Frtz; WD repeat-containing and planar cell polarity effector protein Fritz

  10. XM_063273242.1 → XP_063129312.1  WD repeat-containing and planar cell polarity effector protein fritz homolog isoform X2

  11. XM_063273240.1 → XP_063129310.1  WD repeat-containing and planar cell polarity effector protein fritz homolog isoform X2

  12. XM_039092076.2 → XP_038948004.1  WD repeat-containing and planar cell polarity effector protein fritz homolog isoform X2

    UniProtKB/TrEMBL
    A0A0G2JXB0
    Conserved Domains (2) summary
    sd00039
    Location:310 → 345
    7WD40; WD40 repeat [structural motif]
    pfam11768
    Location:48 → 644
    Frtz; WD repeat-containing and planar cell polarity effector protein Fritz

  13. XM_063273241.1 → XP_063129311.1  WD repeat-containing and planar cell polarity effector protein fritz homolog isoform X2

  14. XM_039092075.2 → XP_038948003.1  WD repeat-containing and planar cell polarity effector protein fritz homolog isoform X2

    UniProtKB/TrEMBL
    A0A0G2JXB0
    Conserved Domains (2) summary
    sd00039
    Location:310 → 345
    7WD40; WD40 repeat [structural motif]
    pfam11768
    Location:48 → 644
    Frtz; WD repeat-containing and planar cell polarity effector protein Fritz

  15. XM_063273250.1 → XP_063129320.1  WD repeat-containing and planar cell polarity effector protein fritz homolog isoform X12

  16. XM_063273248.1 → XP_063129318.1  WD repeat-containing and planar cell polarity effector protein fritz homolog isoform X9

  17. XM_063273243.1 → XP_063129313.1  WD repeat-containing and planar cell polarity effector protein fritz homolog isoform X2

RNA

  1. XR_010057369.1 RNA Sequence

  2. XR_010057368.1 RNA Sequence

  3. XR_010057370.1 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
B1WC10.1 GenPept UniProtKB/Swiss-Prot:B1WC10

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