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Thoc7 THO complex subunit 7 [ Rattus norvegicus (Norway rat) ]

Gene ID: 305714, updated on 2-Nov-2024

Summary

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Official Symbol
Thoc7provided by RGD
Official Full Name
THO complex subunit 7provided by RGD
Primary source
RGD:1305475
See related
EnsemblRapid:ENSRNOG00000007701 AllianceGenome:RGD:1305475
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
RGD1305475
Summary
Predicted to be involved in mRNA export from nucleus. Predicted to be located in chromosome, telomeric region; cytosol; and nuclear speck. Predicted to be part of THO complex part of transcription export complex. Orthologous to human THOC7 (THO complex subunit 7). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Thymus (RPKM 216.3), Kidney (RPKM 180.2) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Thoc7 in Genome Data Viewer
Location:
15p16
Exon count:
13
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 15 NC_086033.1 (13692855..13707692)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 15 NC_051350.1 (11262362..11277200)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 15 NC_005114.4 (12569235..12584101)

Chromosome 15 - NC_086033.1Genomic Context describing neighboring genes Neighboring gene ataxin 7 Neighboring gene uncharacterized LOC134481947 Neighboring gene U6 spliceosomal RNA Neighboring gene similar to human chromosome 3 open reading frame 49 Neighboring gene cadherin related family member 18 Neighboring gene U6 spliceosomal RNA Neighboring gene U4/U6.U5 small nuclear ribonucleoprotein 27 kDa protein-like

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Nuclear localization of the pre-mRNA associating protein THOC7 depends upon its direct interaction with Fms tyrosine kinase interacting protein (FMIP). El Bounkari O, et al. FEBS Lett, 2009 Jan 5. PMID 19059247
  2. Identification and characterization of NIF3L1 BP1, a novel cytoplasmic interaction partner of the NIF3L1 protein. Tascou S, et al. Biochem Biophys Res Commun, 2003 Sep 19. PMID 12951069
  3. Linking transcriptional elongation and messenger RNA export to metastatic breast cancers. Guo S, et al. Cancer Res, 2005 Apr 15. PMID 15833825
  4. mRNA export and the TREX complex. Katahira J. Biochim Biophys Acta, 2012 Jun. PMID 22178508
  5. Recruitment of the complete hTREX complex is required for Kaposi's sarcoma-associated herpesvirus intronless mRNA nuclear export and virus replication. Boyne JR, et al. PLoS Pathog, 2008 Oct. PMID 18974867, Free PMC Article

See all (9) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
  
involved_in mRNA export from nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in mRNA export from nucleus ISO
Inferred from Sequence Orthology
more info
  
involved_in mRNA processing IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
part_of THO complex ISO
Inferred from Sequence Orthology
more info
  
part_of THO complex part of transcription export complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of THO complex part of transcription export complex ISO
Inferred from Sequence Orthology
more info
  
located_in chromosome, telomeric region ISO
Inferred from Sequence Orthology
more info
  
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in cytosol IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in nuclear speck IEA
Inferred from Electronic Annotation
more info
  
located_in nuclear speck ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  
part_of transcription export complex ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
THO complex subunit 7 homolog
Names
THO complex 7 homolog

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001271293.1 → NP_001258222.1  THO complex subunit 7 homolog isoform 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (1).
    Source sequence(s)
    FM110383, JAXUCZ010000015
    UniProtKB/TrEMBL
    F1LXS6
    Related
    ENSRNOP00000010675.7, ENSRNOT00000010675.9
    Conserved Domains (1) summary
    pfam05615
    Location:7 → 136
    THOC7; Tho complex subunit 7

  2. NM_001271294.1 → NP_001258223.1  THO complex subunit 7 homolog isoform 2

    See identical proteins and their annotated locations for NP_001258223.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) has an alternate first exon compared to variant 1. The resulting isoform (2) is shorter at the N-terminus compared to isoform 1.
    Source sequence(s)
    EV771598, FM110383, JAXUCZ010000015
    UniProtKB/TrEMBL
    A6K076
    Conserved Domains (1) summary
    pfam05615
    Location:1 → 87
    THOC7; Tho complex subunit 7

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086033.1 Reference GRCr8

    Range
    13692855..13707692
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006251724.4 → XP_006251786.3  THO complex subunit 7 homolog isoform X1

    UniProtKB/TrEMBL
    A0A8I6ABD9
    Related
    ENSRNOP00000090671.1, ENSRNOT00000096506.2
    Conserved Domains (1) summary
    pfam05615
    Location:66 → 198
    THOC7; Tho complex subunit 7

  2. XM_006251725.4 → XP_006251787.2  THO complex subunit 7 homolog isoform X2

    Related
    ENSRNOP00000071495.3, ENSRNOT00000083787.3

  3. XM_017599648.3 → XP_017455137.1  THO complex subunit 7 homolog isoform X3

    UniProtKB/TrEMBL
    A0A0G2JWV8, F1LXS6
    Related
    ENSRNOP00000089405.2, ENSRNOT00000119585.2
Nucleotide Protein Strain
Heading Accession and Version

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