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Kctd6 potassium channel tetramerization domain containing 6 [ Rattus norvegicus (Norway rat) ]

Gene ID: 305792, updated on 17-Aug-2024

Summary

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Official Symbol
Kctd6provided by RGD
Official Full Name
potassium channel tetramerization domain containing 6provided by RGD
Primary source
RGD:1308208
See related
EnsemblRapid:ENSRNOG00000007817 AllianceGenome:RGD:1308208
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable ankyrin binding activity; cullin family protein binding activity; and identical protein binding activity. Predicted to be involved in negative regulation of smoothened signaling pathway and ubiquitin-dependent protein catabolic process. Orthologous to human KCTD6 (potassium channel tetramerization domain containing 6). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Kidney (RPKM 63.2), Liver (RPKM 42.6) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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Location:
15p14
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 15 NC_086033.1 (19125529..19142038, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 15 NC_051350.1 (16695297..16712460, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 15 NC_005114.4 (18484607..18493188, complement)

Chromosome 15 - NC_086033.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC120096930 Neighboring gene acyl-CoA oxidase 2 Neighboring gene heat shock protein family E (Hsp10) member 1, pseudogene 2 Neighboring gene pyruvate dehydrogenase E1 subunit beta

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Identification and characterization of KCASH2 and KCASH3, 2 novel Cullin3 adaptors suppressing histone deacetylase and Hedgehog activity in medulloblastoma. De Smaele E, et al. Neoplasia, 2011 Apr. PMID 21472142, Free PMC Article
  2. Obscurin and KCTD6 regulate cullin-dependent small ankyrin-1 (sAnk1.5) protein turnover. Lange S, et al. Mol Biol Cell, 2012 Jul. PMID 22573887, Free PMC Article
  3. The BTB domains of the potassium channel tetramerization domain proteins prevalently assume pentameric states. Smaldone G, et al. FEBS Lett, 2016 Jun. PMID 27152988
  4. A proteome-scale map of the human interactome network. Rolland T, et al. Cell, 2014 Nov 20. PMID 25416956, Free PMC Article
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

See all (6) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables ankyrin binding ISO
Inferred from Sequence Orthology
more info
  
enables cullin family protein binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables cullin family protein binding ISO
Inferred from Sequence Orthology
more info
  
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in negative regulation of smoothened signaling pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in protein homooligomerization IEA
Inferred from Electronic Annotation
more info
  
involved_in ubiquitin-dependent protein catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in ubiquitin-dependent protein catabolic process ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
BTB/POZ domain-containing protein KCTD6
Names
potassium channel tetramerisation domain containing 6

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001107253.2 → NP_001100723.1  BTB/POZ domain-containing protein KCTD6 isoform 1

    See identical proteins and their annotated locations for NP_001100723.1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000015
    UniProtKB/TrEMBL
    A6K0B5, B0BNF4, G3V6Z2
    Related
    ENSRNOP00000010303.4, ENSRNOT00000010303.7
    Conserved Domains (1) summary
    cd18394
    Location:10 → 113
    BTB_POZ_KCTD6; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium channel tetramerization domain-containing protein 6 (KCTD6)

  2. NM_001431403.1 → NP_001418332.1  BTB/POZ domain-containing protein KCTD6 isoform 1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000015

  3. NM_001431404.1 → NP_001418333.1  BTB/POZ domain-containing protein KCTD6 isoform 2

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000015

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086033.1 Reference GRCr8

    Range
    19125529..19142038 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039093246.2 → XP_038949174.1  BTB/POZ domain-containing protein KCTD6 isoform X1

    UniProtKB/TrEMBL
    A6K0B5, B0BNF4, G3V6Z2
    Conserved Domains (1) summary
    cd18394
    Location:10 → 113
    BTB_POZ_KCTD6; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium channel tetramerization domain-containing protein 6 (KCTD6)

  2. XM_039093245.2 → XP_038949173.1  BTB/POZ domain-containing protein KCTD6 isoform X1

    UniProtKB/TrEMBL
    A6K0B5, B0BNF4, G3V6Z2
    Related
    ENSRNOP00000101082.1, ENSRNOT00000165981.1
    Conserved Domains (1) summary
    cd18394
    Location:10 → 113
    BTB_POZ_KCTD6; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium channel tetramerization domain-containing protein 6 (KCTD6)

  3. XM_006251763.5 → XP_006251825.1  BTB/POZ domain-containing protein KCTD6 isoform X1

    UniProtKB/TrEMBL
    A6K0B5, B0BNF4, G3V6Z2
    Conserved Domains (1) summary
    cd18394
    Location:10 → 113
    BTB_POZ_KCTD6; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium channel tetramerization domain-containing protein 6 (KCTD6)

  4. XM_039093249.2 → XP_038949177.1  BTB/POZ domain-containing protein KCTD6 isoform X1

    UniProtKB/TrEMBL
    A6K0B5, B0BNF4, G3V6Z2
    Conserved Domains (1) summary
    cd18394
    Location:10 → 113
    BTB_POZ_KCTD6; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium channel tetramerization domain-containing protein 6 (KCTD6)
Nucleotide Protein Strain
Heading Accession and Version

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