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Ttc5 tetratricopeptide repeat domain 5 [ Rattus norvegicus (Norway rat) ]

Gene ID: 305837, updated on 2-Nov-2024

Summary

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Official Symbol
Ttc5provided by RGD
Official Full Name
tetratricopeptide repeat domain 5provided by RGD
Primary source
RGD:1311284
See related
EnsemblRapid:ENSRNOG00000008850 AllianceGenome:RGD:1311284
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable DNA binding activity; chromatin binding activity; and ribosome binding activity. Predicted to be involved in DNA damage response; cellular response to starvation; and positive regulation of mRNA catabolic process. Predicted to act upstream of or within positive regulation of transcription by RNA polymerase II. Predicted to be located in several cellular components, including cytosol; mitochondrion; and nucleoplasm. Orthologous to human TTC5 (tetratricopeptide repeat domain 5). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Thymus (RPKM 165.0), Brain (RPKM 144.9) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Ttc5 in Genome Data Viewer
Location:
15p14
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 15 NC_086033.1 (26466613..26484269, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 15 NC_051350.1 (23993046..24010710, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 15 NC_005114.4 (27698375..27715970, complement)

Chromosome 15 - NC_086033.1Genomic Context describing neighboring genes Neighboring gene olfactory receptor family 11 subfamily H member 23, pseudogene 1 Neighboring gene olfactory receptor family 11 subfamily H member 4 Neighboring gene cyclin B1 interacting protein 1 Neighboring gene small nucleolar RNA SNORD126 Neighboring gene poly (ADP-ribose) polymerase 2 Neighboring gene ribonuclease P RNA component H1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. The p53 cofactor Strap exhibits an unexpected TPR motif and oligonucleotide-binding (OB)-fold structure. Adams CJ, et al. Proc Natl Acad Sci U S A, 2012 Mar 6. PMID 22362889, Free PMC Article
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Gerhard DS, et al. Genome Res, 2004 Oct. PMID 15489334, Free PMC Article
  3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Markers

Homology

Clone Names

  • MGC108914

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables DNA binding ISO
Inferred from Sequence Orthology
more info
  
enables chromatin binding ISO
Inferred from Sequence Orthology
more info
  
enables ribosome binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in DNA damage response ISO
Inferred from Sequence Orthology
more info
  
involved_in DNA damage response ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in DNA repair IEA
Inferred from Electronic Annotation
more info
  
involved_in cellular response to starvation ISO
Inferred from Sequence Orthology
more info
  
involved_in cellular response to starvation ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in positive regulation of mRNA catabolic process ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in cytoplasmic vesicle ISO
Inferred from Sequence Orthology
more info
  
located_in cytoplasmic vesicle ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in cytosol ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in mitochondrial matrix IEA
Inferred from Electronic Annotation
more info
  
located_in mitochondrion ISO
Inferred from Sequence Orthology
more info
  
located_in mitochondrion ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in nucleoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
tetratricopeptide repeat protein 5
Names
TPR repeat protein 5
protein Strap
strap
stress-responsive activator of p300

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001013131.1 → NP_001013149.1  tetratricopeptide repeat protein 5

    See identical proteins and their annotated locations for NP_001013149.1

    Status: PROVISIONAL

    Source sequence(s)
    BC091207
    UniProtKB/Swiss-Prot
    Q5BK48
    UniProtKB/TrEMBL
    A0A8I6GIP6, A6KEA5
    Related
    ENSRNOP00000011741.5, ENSRNOT00000011741.9
    Conserved Domains (3) summary
    COG0457
    Location:47 → 256
    TPR; Tetratricopeptide (TPR) repeat [General function prediction only]
    sd00006
    Location:68 → 97
    TPR; TPR repeat [structural motif]
    pfam16669
    Location:318 → 432
    TTC5_OB; Tetratricopeptide repeat protein 5 OB fold domain

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086033.1 Reference GRCr8

    Range
    26466613..26484269 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063274219.1 → XP_063130289.1  tetratricopeptide repeat protein 5 isoform X1

  2. XM_039093271.2 → XP_038949199.1  tetratricopeptide repeat protein 5 isoform X2

    Conserved Domains (2) summary
    sd00006
    Location:68 → 97
    TPR; TPR repeat [structural motif]
    NF033920
    Location:67 → 131
    C39_PA2778_fam; PA2778 family cysteine peptidase

RNA

  1. XR_010057812.1 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q5BK48.1 GenPept UniProtKB/Swiss-Prot:Q5BK48

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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