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Ang angiogenin [ Rattus norvegicus (Norway rat) ]

Gene ID: 305843, updated on 6-Jun-2024

Summary

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Official Symbol
Angprovided by RGD
Official Full Name
angiogeninprovided by RGD
Primary source
RGD:1594539
See related
AllianceGenome:RGD:1594539
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Ang1
Summary
Predicted to enable several functions, including actin binding activity; heparin binding activity; and protein homodimerization activity. Involved in liver development. Predicted to be located in several cellular components, including growth cone; neuronal cell body; and nucleolus. Predicted to be part of angiogenin-PRI complex. Human ortholog(s) of this gene implicated in diabetic retinopathy; myocardial infarction; neurodegenerative disease (multiple); and prostate cancer. Orthologous to human ANG (angiogenin). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Restricted expression toward (RPKM 3843.4) See more
Orthologs
human mouse all
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Genomic context

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See Ang in Genome Data Viewer
Location:
15p14
Exon count:
3
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 15 NC_086033.1 (26786233..26796883)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 15 NC_051350.1 (24312711..24323361)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 15 NC_005114.4 (28022926..28028636)

Chromosome 15 - NC_086033.1Genomic Context describing neighboring genes Neighboring gene transfer RNA tyrosine (anticodon GUA) 4 Neighboring gene transfer RNA proline (anticodon UGG) 6 Neighboring gene ribonuclease A family member 4 Neighboring gene ribonuclease, RNase A family, 1-like 1 Neighboring gene epididymal protein 3B

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. The dual binding site of angiogenin and its inhibition mechanism: the crystal structure of the rat angiogenin-heparin complex. Yeo KJ, et al. Chem Commun (Camb), 2014 Nov 4. PMID 25219815
  2. Distinct effects of calorie restriction on adipose tissue cytokine and angiogenesis profiles in obese and lean mice. Kurki E, et al. Nutr Metab (Lond), 2012 Jun 29. PMID 22748184, Free PMC Article
  3. Airway angiogenesis in stable and exacerbated chronic obstructive pulmonary disease. Kristan SS, et al. Scand J Immunol, 2012 Jan. PMID 21916917
  4. Peripheral blood monocyte subsets predict antiviral response in chronic hepatitis C. Rodríguez-Muñoz Y, et al. Aliment Pharmacol Ther, 2011 Oct. PMID 21848603
  5. CSF profiles of angiogenic and inflammatory factors depend on the respiratory status of ALS patients. Moreau C, et al. Amyotroph Lateral Scler, 2009 Jun. PMID 19177252

See all (71) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Matrine inhibits synovial angiogenesis in collagen-induced arthritis rats by regulating HIF-VEGF-Ang and inhibiting the PI3K/Akt signaling pathway.
    Title: Matrine inhibits synovial angiogenesis in collagen-induced arthritis rats by regulating HIF-VEGF-Ang and inhibiting the PI3K/Akt signaling pathway.
  2. ANG induced intraocular pressure (IOP) lowering in rat models of both normal and elevated IOP.
    Title: Ribonuclease 5 coordinates signals for the regulation of intraocular pressure and inhibits neural apoptosis as a novel multi-functional anti-glaucomatous strategy.
  3. The heparin complex of rat angiogenin revealed that a heparin strand is fitted into a positively charged groove formed by the dual binding site of rat angiogenin.
    Title: The dual binding site of angiogenin and its inhibition mechanism: the crystal structure of the rat angiogenin-heparin complex.
  4. oxygen-glucose deprivation could induce the expressions of VEGF, Ang-1, and Ang-2, with the expression of Shh signaling components increased.
    Title: Sonic hedgehog (Shh) regulates the expression of angiogenic growth factors in oxygen-glucose-deprived astrocytes by mediating the nuclear receptor NR2F2.
  5. Ang1 induces neurite outgrowth in PC12 cells in a Tie2-independent, beta1-integrin-FAK-PI3K-Akt-dependent manner. NGF and Ang1 mediate neurite outgrowth via two independent signaling mechanisms.
    Title: Angiopoietin-1 induces neurite outgrowth of PC12 cells in a Tie2-independent, beta1-integrin-dependent manner.
Submit: New GeneRIF Correction

General gene information

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Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables RNA nuclease activity ISO
Inferred from Sequence Orthology
more info
  
enables actin binding ISO
Inferred from Sequence Orthology
more info
  
enables copper ion binding ISO
Inferred from Sequence Orthology
more info
  
enables heparin binding ISO
Inferred from Sequence Orthology
more info
  
enables peptide binding ISO
Inferred from Sequence Orthology
more info
  
enables protein homodimerization activity ISO
Inferred from Sequence Orthology
more info
  
enables signaling receptor binding ISO
Inferred from Sequence Orthology
more info
  
enables tRNA-specific ribonuclease activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within angiogenesis ISO
Inferred from Sequence Orthology
more info
  
involved_in angiogenesis ISO
Inferred from Sequence Orthology
more info
  
involved_in antibacterial humoral response ISO
Inferred from Sequence Orthology
more info
  
involved_in antifungal humoral response ISO
Inferred from Sequence Orthology
more info
  
involved_in antimicrobial humoral immune response mediated by antimicrobial peptide ISO
Inferred from Sequence Orthology
more info
  
involved_in cell migration ISO
Inferred from Sequence Orthology
more info
  
involved_in defense response to Gram-positive bacterium ISO
Inferred from Sequence Orthology
more info
  
involved_in diacylglycerol biosynthetic process ISO
Inferred from Sequence Orthology
more info
  
involved_in innate immune response ISO
Inferred from Sequence Orthology
more info
  
involved_in liver development IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in negative regulation of smooth muscle cell proliferation ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of endothelial cell proliferation ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of phosphorylation ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of protein secretion ISO
Inferred from Sequence Orthology
more info
  
involved_in rRNA transcription ISO
Inferred from Sequence Orthology
more info
  
involved_in response to hormone ISO
Inferred from Sequence Orthology
more info
  
involved_in response to hypoxia ISO
Inferred from Sequence Orthology
more info
  
involved_in response to yeast ISO
Inferred from Sequence Orthology
more info
  
involved_in tRNA destabilization ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in actin cytoskeleton ISO
Inferred from Sequence Orthology
more info
  
part_of angiogenin-PRI complex ISO
Inferred from Sequence Orthology
more info
  
located_in basement membrane ISO
Inferred from Sequence Orthology
more info
  
located_in chromosome ISO
Inferred from Sequence Orthology
more info
  
located_in extracellular space ISO
Inferred from Sequence Orthology
more info
  
located_in growth cone ISO
Inferred from Sequence Orthology
more info
  
located_in neuronal cell body ISO
Inferred from Sequence Orthology
more info
  
located_in nucleolus ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
angiogenin
Names
angiogenin ribonuclease 1
angiogenin, ribonuclease A family, member 1
angiogenin, ribonuclease, RNase A family, 5
ribonuclease 4
NP_001006993.2
NP_001398935.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001006992.2 → NP_001006993.2  angiogenin precursor

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000015
    UniProtKB/TrEMBL
    Q5GAM6, Q5WRG2, W0UV65

  2. NM_001412006.1 → NP_001398935.1  angiogenin precursor

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000015
    UniProtKB/TrEMBL
    Q5GAM6, Q5WRG2, W0UV65

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086033.1 Reference GRCr8

    Range
    26786233..26796883
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

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