U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Zfp219 zinc finger protein 219 [ Rattus norvegicus (Norway rat) ]

Gene ID: 305848, updated on 2-Nov-2024

Summary

Go to the top of the page Help
Official Symbol
Zfp219provided by RGD
Official Full Name
zinc finger protein 219provided by RGD
Primary source
RGD:1359259
See related
EnsemblRapid:ENSRNOG00000011544 AllianceGenome:RGD:1359259
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Znf219
Summary
Predicted to enable DNA-binding transcription repressor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in limb bud formation; positive regulation of chondrocyte differentiation; and regulation of transcription by RNA polymerase II. Predicted to be located in nucleoplasm. Predicted to be active in nucleus. Orthologous to human ZNF219 (zinc finger protein 219). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Adrenal (RPKM 83.5), Lung (RPKM 59.9) and 9 other tissues See more
Orthologs
human mouse all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See Zfp219 in Genome Data Viewer
Location:
15p14
Exon count:
12
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 15 NC_086033.1 (27169335..27183555, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 15 NC_051350.1 (24695831..24710039, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 15 NC_005114.4 (28402412..28417379, complement)

Chromosome 15 - NC_086033.1Genomic Context describing neighboring genes Neighboring gene ribonuclease A family member 13 Neighboring gene small nuclear ribonucleoprotein polypeptide C, pseudogene 7 Neighboring gene Rho guanine nucleotide exchange factor 40 Neighboring gene transmembrane protein 253 Neighboring gene ribosomal protein L31 like 10 Neighboring gene olfactory receptor family 5 subfamily AU member 1

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Isolation and characterization of a novel zinc finger gene, ZNF219, and mapping to the human chromosome 14q11 region. Sakai T, et al. DNA Res, 2000 Apr 28. PMID 10819330
  2. Identification of the DNA binding specificity of the human ZNF219 protein and its function as a transcriptional repressor. Sakai T, et al. DNA Res, 2003 Aug 31. PMID 14621294
  3. Functional dissection of the alpha-synuclein promoter: transcriptional regulation by ZSCAN21 and ZNF219. Clough RL, et al. J Neurochem, 2009 Sep. PMID 19549071
  4. The transcription factor Znf219 regulates chondrocyte differentiation by assembling a transcription factory with Sox9. Takigawa Y, et al. J Cell Sci, 2010 Nov 1. PMID 20940257
  5. The negative regulator of Gli, Suppressor of fused (Sufu), interacts with SAP18, Galectin3 and other nuclear proteins. Paces-Fessy M, et al. Biochem J, 2004 Mar 1. PMID 14611647, Free PMC Article

See all (7) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

Go to the top of the page Help

Markers

Homology

Clone Names

  • MGC94294

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables DNA binding ISO
Inferred from Sequence Orthology
more info
  
enables DNA-binding transcription factor activity ISO
Inferred from Sequence Orthology
more info
  
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
  
enables DNA-binding transcription repressor activity, RNA polymerase II-specific ISO
Inferred from Sequence Orthology
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding ISO
Inferred from Sequence Orthology
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in limb bud formation ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of DNA-templated transcription ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of chondrocyte differentiation ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of DNA-templated transcription IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of DNA-templated transcription ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in nucleoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  

General protein information

Go to the top of the page Help
Preferred Names
zinc finger protein 219

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001007681.1 → NP_001007682.1  zinc finger protein 219

    See identical proteins and their annotated locations for NP_001007682.1

    Status: PROVISIONAL

    Source sequence(s)
    BC082017
    UniProtKB/TrEMBL
    A6KEF7, A6KEF8, F7F3U8, Q66H48
    Conserved Domains (4) summary
    sd00017
    Location:503 → 523
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:503 → 523
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:515 → 537
    zf-H2C2_2; Zinc-finger double domain
    pfam13909
    Location:529 → 552
    zf-H2C2_5; C2H2-type zinc-finger domain

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086033.1 Reference GRCr8

    Range
    27169335..27183555 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006251880.5 → XP_006251942.1  zinc finger protein 219 isoform X1

    See identical proteins and their annotated locations for XP_006251942.1

    UniProtKB/TrEMBL
    A6KEF7, A6KEF8, F7F3U8, Q66H48
    Conserved Domains (4) summary
    sd00017
    Location:503 → 523
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:503 → 523
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:515 → 537
    zf-H2C2_2; Zinc-finger double domain
    pfam13909
    Location:529 → 552
    zf-H2C2_5; C2H2-type zinc-finger domain

  2. XM_063274223.1 → XP_063130293.1  zinc finger protein 219 isoform X1

    UniProtKB/TrEMBL
    A6KEF7, A6KEF8, Q66H48
    Related
    ENSRNOP00000080079.1, ENSRNOT00000097305.2

  3. XM_063274224.1 → XP_063130294.1  zinc finger protein 219 isoform X1

    UniProtKB/TrEMBL
    A6KEF7, A6KEF8, Q66H48

  4. XM_017599667.3 → XP_017455156.1  zinc finger protein 219 isoform X1

    UniProtKB/TrEMBL
    A6KEF7, A6KEF8, F7F3U8, Q66H48
    Conserved Domains (4) summary
    sd00017
    Location:503 → 523
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:503 → 523
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:515 → 537
    zf-H2C2_2; Zinc-finger double domain
    pfam13909
    Location:529 → 552
    zf-H2C2_5; C2H2-type zinc-finger domain

  5. XM_039093274.2 → XP_038949202.1  zinc finger protein 219 isoform X1

    UniProtKB/TrEMBL
    A6KEF7, A6KEF8, F7F3U8, Q66H48
    Conserved Domains (4) summary
    sd00017
    Location:503 → 523
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:503 → 523
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:515 → 537
    zf-H2C2_2; Zinc-finger double domain
    pfam13909
    Location:529 → 552
    zf-H2C2_5; C2H2-type zinc-finger domain

  6. XM_039093277.2 → XP_038949205.1  zinc finger protein 219 isoform X1

    UniProtKB/TrEMBL
    A6KEF7, A6KEF8, F7F3U8, Q66H48
    Conserved Domains (4) summary
    sd00017
    Location:503 → 523
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:503 → 523
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:515 → 537
    zf-H2C2_2; Zinc-finger double domain
    pfam13909
    Location:529 → 552
    zf-H2C2_5; C2H2-type zinc-finger domain

  7. XM_039093276.2 → XP_038949204.1  zinc finger protein 219 isoform X1

    UniProtKB/TrEMBL
    A6KEF7, A6KEF8, F7F3U8, Q66H48
    Conserved Domains (4) summary
    sd00017
    Location:503 → 523
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:503 → 523
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:515 → 537
    zf-H2C2_2; Zinc-finger double domain
    pfam13909
    Location:529 → 552
    zf-H2C2_5; C2H2-type zinc-finger domain

  8. XM_039093275.2 → XP_038949203.1  zinc finger protein 219 isoform X1

    UniProtKB/TrEMBL
    A6KEF7, A6KEF8, F7F3U8, Q66H48
    Conserved Domains (4) summary
    sd00017
    Location:503 → 523
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:503 → 523
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:515 → 537
    zf-H2C2_2; Zinc-finger double domain
    pfam13909
    Location:529 → 552
    zf-H2C2_5; C2H2-type zinc-finger domain

  9. XM_006251878.5 → XP_006251940.1  zinc finger protein 219 isoform X1

    See identical proteins and their annotated locations for XP_006251940.1

    UniProtKB/TrEMBL
    A6KEF7, A6KEF8, F7F3U8, Q66H48
    Conserved Domains (4) summary
    sd00017
    Location:503 → 523
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:503 → 523
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:515 → 537
    zf-H2C2_2; Zinc-finger double domain
    pfam13909
    Location:529 → 552
    zf-H2C2_5; C2H2-type zinc-finger domain
Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Molecular Biology Databases
Research Materials
Tools