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Wdfy2 WD repeat and FYVE domain containing 2 [ Rattus norvegicus (Norway rat) ]

Gene ID: 305956, updated on 14-Nov-2024

Summary

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Official Symbol
Wdfy2provided by RGD
Official Full Name
WD repeat and FYVE domain containing 2provided by RGD
Primary source
RGD:1307337
See related
EnsemblRapid:ENSRNOG00000010042 AllianceGenome:RGD:1307337
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable metal ion binding activity. Predicted to be involved in positive regulation of fat cell differentiation and positive regulation of protein phosphorylation. Predicted to be located in cytoplasm; intracellular membrane-bounded organelle; and vesicle. Predicted to be active in early endosome. Orthologous to human WDFY2 (WD repeat and FYVE domain containing 2). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Adrenal (RPKM 250.6), Spleen (RPKM 112.1) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Wdfy2 in Genome Data Viewer
Location:
15p12
Exon count:
14
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 15 NC_086033.1 (41259840..41385549)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 15 NC_051350.1 (37083842..37209559)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 15 NC_005114.4 (46008613..46134319)

Chromosome 15 - NC_086033.1Genomic Context describing neighboring genes Neighboring gene integrator complex subunit 6 Neighboring gene Sec61 translocon subunit gamma, pseudogene 5 Neighboring gene zinc finger CCCH domain-containing protein 13-like Neighboring gene large ribosomal subunit protein eL27-like Neighboring gene uncharacterized LOC120097010 Neighboring gene ribosomal protein L23a, pseudogene 2 Neighboring gene defensin beta 42 Neighboring gene defensin beta 41

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Akt- and Foxo1-interacting WD-repeat-FYVE protein promotes adipogenesis. Fritzius T, et al. EMBO J, 2008 May 7. PMID 18388859, Free PMC Article
  2. WD-repeat-propeller-FYVE protein, ProF, binds VAMP2 and protein kinase Czeta. Fritzius T, et al. FEBS J, 2007 Mar. PMID 17313651
  3. A WD-FYVE protein binds to the kinases Akt and PKCzeta/lambda. Fritzius T, et al. Biochem J, 2006 Oct 1. PMID 16792529, Free PMC Article
  4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in positive regulation of fat cell differentiation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of fat cell differentiation ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of protein phosphorylation ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
is_active_in early endosome IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in early endosome ISO
Inferred from Sequence Orthology
more info
  
located_in intracellular membrane-bounded organelle ISO
Inferred from Sequence Orthology
more info
  
located_in vesicle ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
WD repeat and FYVE domain-containing protein 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001107269.1 → NP_001100739.1  WD repeat and FYVE domain-containing protein 2 isoform 1

    See identical proteins and their annotated locations for NP_001100739.1

    Status: PROVISIONAL

    Source sequence(s)
    CH474023
    UniProtKB/TrEMBL
    A6K6E4, A6K6E5, D4A0J0
    Conserved Domains (5) summary
    smart00320
    Location:285 → 321
    WD40; WD40 repeats
    COG2319
    Location:2 → 321
    WD40; WD40 repeat [General function prediction only]
    cd15718
    Location:206 → 275
    FYVE_WDFY1_like; FYVE domain found in WD40 repeat and FYVE domain-containing protein WDFY1 and WDFY2, and similar proteins
    sd00039
    Location:86 → 124
    7WD40; WD40 repeat [structural motif]
    cl02567
    Location:27 → 199
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

  2. NM_001415102.1 → NP_001402031.1  WD repeat and FYVE domain-containing protein 2 isoform 2

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000015
    UniProtKB/TrEMBL
    A0A0G2K8S4
    Related
    ENSRNOP00000061576.2, ENSRNOT00000066864.4

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086033.1 Reference GRCr8

    Range
    41259840..41385549
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063274283.1 → XP_063130353.1  WD repeat and FYVE domain-containing protein 2 isoform X2

  2. XM_039093327.2 → XP_038949255.1  WD repeat and FYVE domain-containing protein 2 isoform X3

    UniProtKB/TrEMBL
    A6K6E6
    Conserved Domains (3) summary
    cd15718
    Location:190 → 259
    FYVE_WDFY1_like; FYVE domain found in WD40 repeat and FYVE domain-containing protein WDFY1 and WDFY2, and similar proteins
    sd00039
    Location:70 → 108
    7WD40; WD40 repeat [structural motif]
    cl29593
    Location:11 → 183
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

  3. XM_039093325.2 → XP_038949253.1  WD repeat and FYVE domain-containing protein 2 isoform X1

    UniProtKB/TrEMBL
    A6K6E5
    Related
    ENSRNOP00000074718.2, ENSRNOT00000080537.3
    Conserved Domains (3) summary
    cd15718
    Location:241 → 310
    FYVE_WDFY1_like; FYVE domain found in WD40 repeat and FYVE domain-containing protein WDFY1 and WDFY2, and similar proteins
    sd00039
    Location:121 → 159
    7WD40; WD40 repeat [structural motif]
    cl29593
    Location:30 → 238
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

  4. XM_039093328.1 → XP_038949256.1  WD repeat and FYVE domain-containing protein 2 isoform X4

    Conserved Domains (3) summary
    cd15718
    Location:161 → 230
    FYVE_WDFY1_like; FYVE domain found in WD40 repeat and FYVE domain-containing protein WDFY1 and WDFY2, and similar proteins
    sd00039
    Location:41 → 79
    7WD40; WD40 repeat [structural motif]
    cl29593
    Location:9 → 154
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
Nucleotide Protein Strain
Heading Accession and Version

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