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Cdca2 cell division cycle associated 2 [ Rattus norvegicus (Norway rat) ]

Gene ID: 305984, updated on 27-Jul-2024

Summary

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Official Symbol
Cdca2provided by RGD
Official Full Name
cell division cycle associated 2provided by RGD
Primary source
RGD:1311003
See related
EnsemblRapid:ENSRNOG00000025302 AllianceGenome:RGD:1311003
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to be involved in regulation of chromosome segregation and regulation of mitotic nuclear division. Predicted to act upstream of or within chromosome segregation and positive regulation of protein dephosphorylation. Predicted to be located in cytosol and nucleoplasm. Predicted to be active in chromosome and nucleus. Orthologous to human CDCA2 (cell division cycle associated 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Testes (RPKM 305.1), Thymus (RPKM 107.7) and 1 other tissue See more
Orthologs
human mouse all
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Genomic context

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See Cdca2 in Genome Data Viewer
Location:
15p12
Exon count:
17
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 15 NC_086033.1 (46071360..46117524, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 15 NC_051350.1 (41895946..41942226, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 15 NC_005114.4 (44365396..44411601, complement)

Chromosome 15 - NC_086033.1Genomic Context describing neighboring genes Neighboring gene small nucleolar RNA SNORA17 Neighboring gene ribosomal protein L36, pseudogene Neighboring gene uncharacterized LOC103693653 Neighboring gene potassium channel tetramerization domain containing 9 Neighboring gene gonadotropin releasing hormone 1 Neighboring gene dedicator of cytokinesis 5

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Sds22 and Repo-Man stabilize chromosome segregation by counteracting Aurora B on anaphase kinetochores. Wurzenberger C, et al. J Cell Biol, 2012 Jul 23. PMID 22801782, Free PMC Article
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
  3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by RGD

Process Evidence Code Pubs
acts_upstream_of_or_within chromosome segregation ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within positive regulation of protein dephosphorylation ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of chromosome segregation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of mitotic nuclear division IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in chromosome IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in chromosome ISO
Inferred from Sequence Orthology
more info
  
located_in cytosol IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
cell division cycle-associated protein 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001431437.1 → NP_001418366.1  cell division cycle-associated protein 2 isoform 1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000015

  2. NM_001431438.1 → NP_001418367.1  cell division cycle-associated protein 2 isoform 1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000015

  3. NM_001431439.1 → NP_001418368.1  cell division cycle-associated protein 2 isoform 1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000015

  4. NM_001431440.1 → NP_001418369.1  cell division cycle-associated protein 2 isoform 1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000015

  5. NM_001431441.1 → NP_001418370.1  cell division cycle-associated protein 2 isoform 2

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000015

  6. NM_001431442.1 → NP_001418371.1  cell division cycle-associated protein 2 isoform 3

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000015

  7. NM_001431443.1 → NP_001418372.1  cell division cycle-associated protein 2 isoform 3

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000015

  8. NM_001431444.1 → NP_001418373.1  cell division cycle-associated protein 2 isoform 4

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000015

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086033.1 Reference GRCr8

    Range
    46071360..46117524 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017599696.3 → XP_017455185.1  cell division cycle-associated protein 2 isoform X1

    UniProtKB/TrEMBL
    D4ADI8
    Conserved Domains (1) summary
    pfam15276
    Location:371 → 427
    PP1_bind; Protein phosphatase 1 binding

  2. XM_063274292.1 → XP_063130362.1  cell division cycle-associated protein 2 isoform X1

    UniProtKB/TrEMBL
    D4ADI8

  3. XM_006252118.5 → XP_006252180.1  cell division cycle-associated protein 2 isoform X1

    UniProtKB/TrEMBL
    D4ADI8
    Conserved Domains (1) summary
    pfam15276
    Location:371 → 427
    PP1_bind; Protein phosphatase 1 binding

  4. XM_006252120.5 → XP_006252182.1  cell division cycle-associated protein 2 isoform X2

    UniProtKB/TrEMBL
    D4ADI8
    Conserved Domains (1) summary
    pfam15276
    Location:370 → 426
    PP1_bind; Protein phosphatase 1 binding

  5. XM_006252117.5 → XP_006252179.1  cell division cycle-associated protein 2 isoform X1

    UniProtKB/TrEMBL
    D4ADI8
    Conserved Domains (1) summary
    pfam15276
    Location:371 → 427
    PP1_bind; Protein phosphatase 1 binding

  6. XM_008770757.4 → XP_008768979.1  cell division cycle-associated protein 2 isoform X4

    UniProtKB/TrEMBL
    A0A8I5ZNC7
    Conserved Domains (1) summary
    pfam15276
    Location:225 → 281
    PP1_bind; Protein phosphatase 1 binding

  7. XM_063274293.1 → XP_063130363.1  cell division cycle-associated protein 2 isoform X3

    UniProtKB/TrEMBL
    A0A8I5ZNC7

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001107273.1: Suppressed sequence

    Description
    NM_001107273.1: This RefSeq was removed because currently there is insufficient support for the transcript and the protein.
Nucleotide Protein Strain
Heading Accession and Version

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