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Lgi3 leucine-rich repeat LGI family, member 3 [ Rattus norvegicus (Norway rat) ]

Gene ID: 306013, updated on 10-Jul-2024

Summary

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Official Symbol
Lgi3provided by RGD
Official Full Name
leucine-rich repeat LGI family, member 3provided by RGD
Primary source
RGD:1311079
See related
EnsemblRapid:ENSRNOG00000011323 AllianceGenome:RGD:1311079
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable catalytic activity. Predicted to be involved in regulation of exocytosis. Predicted to be located in extracellular region. Predicted to be active in synaptic vesicle. Orthologous to human LGI3 (leucine rich repeat LGI family member 3). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Lung (RPKM 328.7), Brain (RPKM 201.9) and 2 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Lgi3 in Genome Data Viewer
Location:
15p11
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 15 NC_086033.1 (52015317..52022445)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 15 NC_051350.1 (45605611..45612739)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 15 NC_005114.4 (52220578..52227706)

Chromosome 15 - NC_086033.1Genomic Context describing neighboring genes Neighboring gene bone morphogenetic protein 1 Neighboring gene uncharacterized LOC134482143 Neighboring gene surfactant protein C Neighboring gene uncharacterized LOC134482145 Neighboring gene receptor accessory protein 4

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Abeta upregulates and colocalizes with LGI3 in cultured rat astrocytes. Kimura N, et al. Cell Mol Neurobiol, 2007 May. PMID 17387609
  2. Leucine-rich glioma inactivated 3 associates with syntaxin 1. Park WJ, et al. Neurosci Lett, 2008 Oct 31. PMID 18760330
  3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
  4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Activated LGI3 may be involved in the astroglial response against Amyloid beta.
    Title: Abeta upregulates and colocalizes with LGI3 in cultured rat astrocytes.
Submit: New GeneRIF Correction

General gene information

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Homology

Gene Ontology Provided by RGD

Process Evidence Code Pubs
involved_in regulation of exocytosis IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of exocytosis ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in extracellular space ISO
Inferred from Sequence Orthology
more info
  
located_in juxtaparanode region of axon ISO
Inferred from Sequence Orthology
more info
  
is_active_in synaptic vesicle IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in synaptic vesicle ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
leucine-rich repeat LGI family member 3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001107277.1 → NP_001100747.1  leucine-rich repeat LGI family member 3 precursor

    See identical proteins and their annotated locations for NP_001100747.1

    Status: PROVISIONAL

    Source sequence(s)
    CH473951
    UniProtKB/TrEMBL
    A6HTL0, A6HTL1, D3ZN61
    Related
    ENSRNOP00000015104.4, ENSRNOT00000015104.7
    Conserved Domains (6) summary
    smart00370
    Location:135 → 158
    LRR; Leucine-rich repeats, outliers
    sd00031
    Location:68 → 89
    LRR_1; leucine-rich repeat [structural motif]
    pfam03736
    Location:222 → 263
    EPTP; EPTP domain
    pfam12799
    Location:113 → 152
    LRR_4; Leucine Rich repeats (2 copies)
    pfam13855
    Location:112 → 172
    LRR_8; Leucine rich repeat
    cl15307
    Location:170 → 218
    TPKR_C2; Tyrosine-protein kinase receptor C2 Ig-like domain

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086033.1 Reference GRCr8

    Range
    52015317..52022445
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039093351.1 → XP_038949279.1  leucine-rich repeat LGI family member 3 isoform X1

    UniProtKB/TrEMBL
    A6HTL1
    Conserved Domains (4) summary
    TIGR00864
    Location:92 → 167
    PCC; polycystin cation channel protein
    sd00031
    Location:63 → 86
    LRR_1; leucine-rich repeat [structural motif]
    pfam03736
    Location:171 → 210
    EPTP; EPTP domain
    pfam13855
    Location:61 → 121
    LRR_8; Leucine rich repeat
Nucleotide Protein Strain
Heading Accession and Version

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