Itih1 inter-alpha trypsin inhibitor, heavy chain 1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Itih1provided by RGD
Official Full Name: inter-alpha trypsin inhibitor, heavy chain 1provided by RGD
Primary source: RGD:1306099
See related: EnsemblRapid:ENSRNOG00000033386 AllianceGenome:RGD:1306099
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable serine-type endopeptidase inhibitor activity. Predicted to be involved in hyaluronan metabolic process and negative regulation of endopeptidase activity. Predicted to act upstream of or within extracellular matrix organization. Predicted to be located in extracellular matrix. Orthologous to human ITIH1 (inter-alpha-trypsin inhibitor heavy chain 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Restricted expression toward (RPKM 3969.5) See more
Orthologs: human mouse all
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Genomic context

Location:: 16p16

Exon count:: 22

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	16	NC_086034.1 (6128696..6142813, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	16	NC_051351.1 (6122246..6136363, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	16	NC_005115.4 (7012376..7026542, complement)

Chromosome 16 - NC_086034.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

This study demonstrated that Alterations in Itih1 expression after hypoxic-ischemic brain injury in neonatal rats
Title: Alterations in inter-alpha inhibitor protein expression after hypoxic-ischemic brain injury in neonatal rats.

Submit: New GeneRIF Correction

General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables carbohydrate binding	ISO Inferred from Sequence Orthology more info
enables hyaluronic acid binding	ISO Inferred from Sequence Orthology more info
enables serine-type endopeptidase inhibitor activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within extracellular matrix organization	ISO Inferred from Sequence Orthology more info
involved_in hyaluronan metabolic process	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in extracellular matrix	ISO Inferred from Sequence Orthology more info
located_in extracellular region	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: inter-alpha-trypsin inhibitor heavy chain H1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001107291.2 → NP_001100761.2 inter-alpha-trypsin inhibitor heavy chain H1 precursor

See identical proteins and their annotated locations for NP_001100761.2

Status: VALIDATED

Source sequence(s)

BC166831

UniProtKB/TrEMBL

A6KG18, B2RYM3

Related

ENSRNOP00000103070.1, ENSRNOT00000137918.1

Conserved Domains (4) summary

smart00609
Location:33 → 160

VIT; Vault protein Inter-alpha-Trypsin domain

cd01461
Location:283 → 464

vWA_interalpha_trypsin_inhibitor; vWA_interalpha trypsin inhibitor (ITI): ITI is a glycoprotein composed of three polypeptides- two heavy chains and one light chain (bikunin). Bikunin confers the protease-inhibitor function while the heavy chains are involved in rendering stability to ...

TIGR03788
Location:52 → 602

marine_srt_targ; marine proteobacterial sortase target protein

pfam06668
Location:699 → 884

ITI_HC_C; Inter-alpha-trypsin inhibitor heavy chain C-terminus