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Syt15 synaptotagmin 15 [ Rattus norvegicus (Norway rat) ]

Gene ID: 306285, updated on 28-Oct-2024

Summary

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Official Symbol
Syt15provided by RGD
Official Full Name
synaptotagmin 15provided by RGD
Primary source
RGD:727964
See related
EnsemblRapid:ENSRNOG00000051688 AllianceGenome:RGD:727964
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
sytXV
Summary
Predicted to enable SNARE binding activity; calcium ion sensor activity; and calcium-dependent phospholipid binding activity. Predicted to be involved in regulation of calcium ion-dependent exocytosis and vesicle-mediated transport. Predicted to be located in membrane. Predicted to be active in exocytic vesicle and plasma membrane. Orthologous to human SYT15 (synaptotagmin 15). [provided by Alliance of Genome Resources, Oct 2024]
Expression
Biased expression in Lung (RPKM 19.5), Kidney (RPKM 10.9) and 9 other tissues See more
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Genomic context

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See Syt15 in Genome Data Viewer
Location:
16p15
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 16 NC_086034.1 (9538740..9549548)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 16 NC_051351.1 (9532478..9543288)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 16 NC_005115.4 (10554136..10564934)

Chromosome 16 - NC_086034.1Genomic Context describing neighboring genes Neighboring gene neuropeptide Y receptor Y4 Neighboring gene G protein regulated inducer of neurite outgrowth 2 Neighboring gene shieldin complex subunit 2 Neighboring gene ZW10 interacting kinetochore protein, pseudogene 1 Neighboring gene small nucleolar RNA SNORA15

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Expression of matrix metalloproteinase, tissue inhibitors of metalloproteinase and adhesion molecules in silicotic mice with lung tumor metastasis. Ishihara Y, et al. Toxicol Lett, 2003 Apr 30. PMID 12765241
  2. Molecular cloning and characterization of human, rat, and mouse synaptotagmin XV. Fukuda M. Biochem Biophys Res Commun, 2003 Jun 20. PMID 12788067
  3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
  4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. molecular cloning and structure
    Title: Molecular cloning and characterization of human, rat, and mouse synaptotagmin XV.
Submit: New GeneRIF Correction

General gene information

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Markers

Homology

Clone Names

  • MGC91393

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables SNARE binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables calcium ion sensor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables calcium-dependent phospholipid binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in regulation of calcium ion-dependent exocytosis IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in vesicle-mediated transport IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in exocytic vesicle IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in membrane ISO
Inferred from Sequence Orthology
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
synaptotagmin-15
Names
synaptotagmin XV

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_181632.2 → NP_853663.2  synaptotagmin-15

    See identical proteins and their annotated locations for NP_853663.2

    Status: PROVISIONAL

    Source sequence(s)
    BC084685
    UniProtKB/Swiss-Prot
    P59926
    UniProtKB/TrEMBL
    A0A0G2KAX3, A6KFS7, F1LQ33, Q5XFY6
    Related
    ENSRNOP00000075561.2, ENSRNOT00000079030.3
    Conserved Domains (2) summary
    cd08390
    Location:150 → 270
    C2A_Synaptotagmin-15-17; C2A domain first repeat present in Synaptotagmins 15 and 17
    cd08409
    Location:280 → 417
    C2B_Synaptotagmin-15; C2 domain second repeat present in Synaptotagmin 15

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086034.1 Reference GRCr8

    Range
    9538740..9549548
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P59926.1 GenPept UniProtKB/Swiss-Prot:P59926

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
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