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Mmrn2 multimerin 2 [ Rattus norvegicus (Norway rat) ]

Gene ID: 306288, updated on 13-Apr-2024

Summary

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Official Symbol
Mmrn2provided by RGD
Official Full Name
multimerin 2provided by RGD
Primary source
RGD:1311461
See related
Ensembl:ENSRNOG00000051977 AllianceGenome:RGD:1311461
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to be involved in cell migration involved in sprouting angiogenesis; negative regulation of cell migration involved in sprouting angiogenesis; and negative regulation of vascular endothelial growth factor receptor signaling pathway. Predicted to be located in basement membrane and extracellular space. Orthologous to human MMRN2 (multimerin 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Heart (RPKM 159.0), Lung (RPKM 138.1) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Mmrn2 in Genome Data Viewer
Location:
16p15
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 16 NC_086034.1 (9712181..9733653)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 16 NC_051351.1 (9705925..9727405)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 16 NC_005115.4 (10727552..10749303)

Chromosome 16 - NC_086034.1Genomic Context describing neighboring genes Neighboring gene family with sequence similarity 25, member A Neighboring gene synuclein, gamma Neighboring gene bone morphogenetic protein receptor type 1A Neighboring gene T-enol, pseudogene 1 Neighboring gene uncharacterized LOC108353075

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Molecular cloning and characterization of EndoGlyx-1, an EMILIN-like multisubunit glycoprotein of vascular endothelium. Christian S, et al. J Biol Chem, 2001 Dec 21. PMID 11559704
  2. Blocking CLEC14A-MMRN2 binding inhibits sprouting angiogenesis and tumour growth. Noy PJ, et al. Oncogene, 2015 Nov 19. PMID 25745997, Free PMC Article
  3. MULTIMERIN2 impairs tumor angiogenesis and growth by interfering with VEGF-A/VEGFR2 pathway. Lorenzon E, et al. Oncogene, 2012 Jun 28. PMID 22020326
  4. Transcriptome-based systematic identification of extracellular matrix proteins. Manabe R, et al. Proc Natl Acad Sci U S A, 2008 Sep 2. PMID 18757743, Free PMC Article
  5. SILAC-based proteomics of human primary endothelial cell morphogenesis unveils tumor angiogenic markers. Zanivan S, et al. Mol Cell Proteomics, 2013 Dec. PMID 23979707, Free PMC Article

See all (9) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Process Evidence Code Pubs
involved_in cell migration involved in sprouting angiogenesis ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of cell migration ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of cell migration involved in sprouting angiogenesis IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in negative regulation of cell migration involved in sprouting angiogenesis ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of cell population proliferation ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of vascular endothelial growth factor receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in negative regulation of vascular endothelial growth factor receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of defense response to bacterium ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of epithelial tube formation ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of morphogenesis of an epithelium ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in basement membrane ISO
Inferred from Sequence Orthology
more info
  
located_in collagen-containing extracellular matrix ISO
Inferred from Sequence Orthology
more info
  
located_in extracellular space ISO
Inferred from Sequence Orthology
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
multimerin-2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001372014.1 → NP_001358943.1  multimerin-2 precursor

    Status: VALIDATED

    Source sequence(s)
    FQ218167, JAXUCZ010000016
    UniProtKB/TrEMBL
    A0A8I6GHU7
    Related
    ENSRNOP00000074627.2, ENSRNOT00000084422.2
    Conserved Domains (4) summary
    TIGR02168
    Location:518 → 777
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    pfam15921
    Location:249 → 585
    CCDC158; Coiled-coil domain-containing protein 158
    pfam00386
    Location:811 → 930
    C1q; C1q domain
    pfam07546
    Location:57 → 127
    EMI; EMI domain

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086034.1 Reference GRCr8

    Range
    9712181..9733653
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039094475.2 → XP_038950403.1  multimerin-2 isoform X1

    UniProtKB/TrEMBL
    A0A8I6GHU7
    Conserved Domains (3) summary
    pfam15921
    Location:292 → 650
    CCDC158; Coiled-coil domain-containing protein 158
    pfam00386
    Location:854 → 973
    C1q; C1q domain
    pfam07546
    Location:100 → 170
    EMI; EMI domain

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001107298.1: Suppressed sequence

    Description
    NM_001107298.1: This RefSeq was suppressed temporarily based on the calculation that the encoded protein was shorter than proteins from the putative ortholog from human: MMRN2 (GeneID:79812).
Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

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