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Ano8 anoctamin 8 [ Rattus norvegicus (Norway rat) ]

Gene ID: 306340, updated on 10-Oct-2024

Summary

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Official Symbol
Ano8provided by RGD
Official Full Name
anoctamin 8provided by RGD
Primary source
RGD:1563946
See related
EnsemblRapid:ENSRNOG00000058662 AllianceGenome:RGD:1563946
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
RGD1563946
Summary
Predicted to enable intracellular calcium activated chloride channel activity. Predicted to be involved in chloride transport and transmembrane transport. Predicted to be integral component of membrane. Predicted to be active in plasma membrane. Orthologous to human ANO8 (anoctamin 8). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Muscle (RPKM 74.2), Brain (RPKM 71.0) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Ano8 in Genome Data Viewer
Location:
16p14
Exon count:
20
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 16 NC_086034.1 (18197829..18207205, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 16 NC_051351.1 (18163853..18173248, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 16 NC_005115.4 (19884661..19894608, complement)

Chromosome 16 - NC_086034.1Genomic Context describing neighboring genes Neighboring gene abhydrolase domain containing 8 Neighboring gene mitochondrial ribosomal protein L34 Neighboring gene DET1 and DDB1 associated 1 Neighboring gene GTP binding protein 3 Neighboring gene uncharacterized LOC134482466 Neighboring gene plasmalemma vesicle associated protein

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. CFTR and TMEM16A are separate but functionally related Cl- channels. Ousingsawat J, et al. Cell Physiol Biochem, 2011. PMID 22178883
  2. Expression and function of epithelial anoctamins. Schreiber R, et al. J Biol Chem, 2010 Mar 5. PMID 20056604, Free PMC Article
  3. Anoctamins are a family of Ca2+-activated Cl- channels. Tian Y, et al. J Cell Sci, 2012 Nov 1. PMID 22946059
  4. The anoctamin family: TMEM16A and TMEM16B as calcium-activated chloride channels. Scudieri P, et al. Exp Physiol, 2012 Feb. PMID 21984732
  5. Calcium-dependent phospholipid scramblase activity of TMEM16 protein family members. Suzuki J, et al. J Biol Chem, 2013 May 10. PMID 23532839, Free PMC Article

See all (6) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables chloride channel activity IBA
Inferred from Biological aspect of Ancestor
more info
  
NOT enables intracellularly calcium-gated chloride channel activity ISO
Inferred from Sequence Orthology
more info
  
enables intracellularly calcium-gated chloride channel activity ISO
Inferred from Sequence Orthology
more info
  
NOT enables phospholipid scramblase activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in chloride transmembrane transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in chloride transmembrane transport ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
anoctamin-8

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001427623.1 → NP_001414552.1  anoctamin-8

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000016
    UniProtKB/TrEMBL
    A0A8I6AJK6
    Related
    ENSRNOP00000085290.1, ENSRNOT00000111787.2

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086034.1 Reference GRCr8

    Range
    18197829..18207205 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039095002.2 → XP_038950930.1  anoctamin-8 isoform X5

    UniProtKB/TrEMBL
    A0A8I6GCQ3
    Related
    ENSRNOP00000094433.2, ENSRNOT00000093953.2
    Conserved Domains (2) summary
    PRK12323
    Location:908 → 1086
    PRK12323; DNA polymerase III subunit gamma/tau
    pfam04547
    Location:184 → 860
    Anoctamin; Calcium-activated chloride channel

  2. XM_039094999.2 → XP_038950927.1  anoctamin-8 isoform X3

    UniProtKB/TrEMBL
    A0A8I6GCQ3
    Conserved Domains (2) summary
    PRK12323
    Location:922 → 1100
    PRK12323; DNA polymerase III subunit gamma/tau
    pfam04547
    Location:198 → 874
    Anoctamin; Calcium-activated chloride channel

  3. XM_039094998.2 → XP_038950926.1  anoctamin-8 isoform X2

    UniProtKB/TrEMBL
    A0A8I6GCQ3
    Conserved Domains (2) summary
    PRK12323
    Location:945 → 1123
    PRK12323; DNA polymerase III subunit gamma/tau
    pfam04547
    Location:221 → 897
    Anoctamin; Calcium-activated chloride channel

  4. XM_039095003.2 → XP_038950931.1  anoctamin-8 isoform X6

    UniProtKB/TrEMBL
    A0A8I6GCQ3
    Conserved Domains (2) summary
    PRK12323
    Location:892 → 1070
    PRK12323; DNA polymerase III subunit gamma/tau
    pfam04547
    Location:237 → 844
    Anoctamin; Calcium-activated chloride channel

  5. XM_039094997.2 → XP_038950925.1  anoctamin-8 isoform X1

    UniProtKB/TrEMBL
    A0A8I6GCQ3
    Conserved Domains (2) summary
    PRK12323
    Location:961 → 1139
    PRK12323; DNA polymerase III subunit gamma/tau
    pfam04547
    Location:237 → 913
    Anoctamin; Calcium-activated chloride channel

  6. XM_039095000.2 → XP_038950928.1  anoctamin-8 isoform X4

    UniProtKB/TrEMBL
    A0A0G2K5K1, A0A8I6A8H8
    Related
    ENSRNOP00000073456.2, ENSRNOT00000085940.3
    Conserved Domains (2) summary
    PRK12323
    Location:917 → 1095
    PRK12323; DNA polymerase III subunit gamma/tau
    pfam04547
    Location:237 → 869
    Anoctamin; Calcium-activated chloride channel
Nucleotide Protein Strain
Heading Accession and Version

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