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Cilp2 cartilage intermediate layer protein 2 [ Rattus norvegicus (Norway rat) ]

Gene ID: 306356, updated on 2-Nov-2024

Summary

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Official Symbol
Cilp2provided by RGD
Official Full Name
cartilage intermediate layer protein 2provided by RGD
Primary source
RGD:1311157
See related
EnsemblRapid:ENSRNOG00000020622 AllianceGenome:RGD:1311157
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to be active in extracellular space. Orthologous to human CILP2 (cartilage intermediate layer protein 2). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Adrenal (RPKM 97.4), Muscle (RPKM 81.3) and 2 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Cilp2 in Genome Data Viewer
Location:
16p14
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 16 NC_086034.1 (19573821..19581100)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 16 NC_051351.1 (19539755..19547191)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 16 NC_005115.4 (21288782..21295869)

Chromosome 16 - NC_086034.1Genomic Context describing neighboring genes Neighboring gene NADH:ubiquinone oxidoreductase subunit A13 Neighboring gene YjeF N-terminal domain containing 3 Neighboring gene PBX homeobox 4 Neighboring gene lysophosphatidic acid receptor 2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. One of two chondrocyte-expressed isoforms of cartilage intermediate-layer protein functions as an insulin-like growth factor 1 antagonist. Johnson K, et al. Arthritis Rheum, 2003 May. PMID 12746903
  2. In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine. Principe S, et al. Proteomics, 2013 May. PMID 23533145, Free PMC Article
  3. Proteomic analysis of podocyte exosome-enriched fraction from normal human urine. Prunotto M, et al. J Proteomics, 2013 Apr 26. PMID 23376485
  4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
NOT enables alkaline phosphatase activity ISO
Inferred from Sequence Orthology
more info
  
NOT enables dinucleotide phosphatase activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
  
Component Evidence Code Pubs
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
cartilage intermediate layer protein 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001107307.1 → NP_001100777.1  cartilage intermediate layer protein 2 precursor

    See identical proteins and their annotated locations for NP_001100777.1

    Status: PROVISIONAL

    Source sequence(s)
    CH474031
    UniProtKB/TrEMBL
    A6KAA7, D3ZE05
    Related
    ENSRNOP00000027990.5, ENSRNOT00000027990.7
    Conserved Domains (6) summary
    smart00408
    Location:333 → 393
    IGc2; Immunoglobulin C-2 Type
    smart00209
    Location:168 → 207
    TSP1; Thrombospondin type 1 repeats
    smart00410
    Location:325 → 404
    IG_like; Immunoglobulin like
    pfam13330
    Location:58 → 143
    Mucin2_WxxW; Mucin-2 protein WxxW repeating region
    pfam13620
    Location:239 → 313
    CarboxypepD_reg; Carboxypeptidase regulatory-like domain
    pfam13715
    Location:502 → 553
    CarbopepD_reg_2; CarboxypepD_reg-like domain

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086034.1 Reference GRCr8

    Range
    19573821..19581100
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006252902.5 → XP_006252964.1  cartilage intermediate layer protein 2 isoform X1

    Conserved Domains (6) summary
    smart00408
    Location:307 → 367
    IGc2; Immunoglobulin C-2 Type
    smart00209
    Location:158 → 197
    TSP1; Thrombospondin type 1 repeats
    smart00410
    Location:299 → 378
    IG_like; Immunoglobulin like
    pfam13330
    Location:58 → 143
    Mucin2_WxxW; Mucin-2 protein WxxW repeating region
    pfam13620
    Location:213 → 287
    CarboxypepD_reg; Carboxypeptidase regulatory-like domain
    pfam13715
    Location:476 → 527
    CarbopepD_reg_2; CarboxypepD_reg-like domain
Nucleotide Protein Strain
Heading Accession and Version

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