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Fbxo8 F-box protein 8 [ Rattus norvegicus (Norway rat) ]

Gene ID: 306436, updated on 28-Oct-2024

Summary

Official Symbol
Fbxo8provided by RGD
Official Full Name
F-box protein 8provided by RGD
Primary source
RGD:1307596
See related
EnsemblRapid:ENSRNOG00000010502 AllianceGenome:RGD:1307596
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable guanyl-nucleotide exchange factor activity. Predicted to be involved in regulation of ARF protein signal transduction. Predicted to act upstream of or within ubiquitin-dependent protein catabolic process. Predicted to be part of ubiquitin ligase complex. Orthologous to human FBXO8 (F-box protein 8). [provided by Alliance of Genome Resources, Oct 2024]
Expression
Biased expression in Liver (RPKM 133.3), Kidney (RPKM 131.2) and 9 other tissues See more
Orthologs
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Genomic context

See Fbxo8 in Genome Data Viewer
Location:
16p11
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 16 NC_086034.1 (38676011..38721849, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 16 NC_051351.1 (33665305..33711215, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 16 NC_005115.4 (37131566..37177033, complement)

Chromosome 16 - NC_086034.1Genomic Context describing neighboring genes Neighboring gene phosphatidylethanolamine binding protein 1, pseudogene 1 Neighboring gene U4 spliceosomal RNA Neighboring gene small nucleolar RNA SNORA17 Neighboring gene centrosomal protein 44

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001012050.1NP_001012050.1  F-box only protein 8

    See identical proteins and their annotated locations for NP_001012050.1

    Status: PROVISIONAL

    Source sequence(s)
    BC088452
    UniProtKB/TrEMBL
    A0A0G2K0C3, A6KIX1, F1M701, Q5M7U1
    Related
    ENSRNOP00000071387.1, ENSRNOT00000084469.3
    Conserved Domains (2) summary
    cd00171
    Location:133312
    Sec7; Sec7 domain; Domain named after the S. cerevisiae SEC7 gene product. The Sec7 domain is the central domain of the guanine-nucleotide-exchange factors (GEFs) of the ADP-ribosylation factor family of small GTPases (ARFs) . It carries the exchange factor ...
    pfam12937
    Location:74112
    F-box-like

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086034.1 Reference GRCr8

    Range
    38676011..38721849 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063275410.1XP_063131480.1  F-box only protein 8 isoform X2

  2. XM_063275408.1XP_063131478.1  F-box only protein 8 isoform X1

    UniProtKB/TrEMBL
    A0A0G2K0C3, F1M701, Q5M7U1
  3. XM_063275409.1XP_063131479.1  F-box only protein 8 isoform X1

    UniProtKB/TrEMBL
    A0A0G2K0C3, F1M701, Q5M7U1
  4. XM_063275411.1XP_063131481.1  F-box only protein 8 isoform X3

  5. XM_039094500.2XP_038950428.1  F-box only protein 8 isoform X3

    Conserved Domains (1) summary
    cd00171
    Location:1155
    Sec7; Sec7 domain; Domain named after the S. cerevisiae SEC7 gene product. The Sec7 domain is the central domain of the guanine-nucleotide-exchange factors (GEFs) of the ADP-ribosylation factor family of small GTPases (ARFs) . It carries the exchange factor ...
  6. XM_063275412.1XP_063131482.1  F-box only protein 8 isoform X4