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Cdkn2aip CDKN2A interacting protein [ Rattus norvegicus (Norway rat) ]

Gene ID: 306455, updated on 2-Nov-2024

Summary

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Official Symbol
Cdkn2aipprovided by RGD
Official Full Name
CDKN2A interacting proteinprovided by RGD
Primary source
RGD:1305302
See related
EnsemblRapid:ENSRNOG00000022736 AllianceGenome:RGD:1305302
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
RGD1305302
Summary
Predicted to enable p53 binding activity. Predicted to be involved in several processes, including DNA damage response; regulation of cell growth; and regulation of protein stability. Predicted to be located in granular component. Predicted to be active in nucleolus and nucleoplasm. Orthologous to human CDKN2AIP (CDKN2A interacting protein). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Testes (RPKM 159.1), Thymus (RPKM 114.9) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Cdkn2aip in Genome Data Viewer
Location:
16q11
Exon count:
4
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 16 NC_086034.1 (51266613..51274051)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 16 NC_051351.1 (44536147..44546216)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 16 NC_005115.4 (47664864..47670935)

Chromosome 16 - NC_086034.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134482379 Neighboring gene proteasome subunit alpha type-5-like Neighboring gene uncharacterized LOC102551260 Neighboring gene uncharacterized LOC134482502 Neighboring gene inhibitor of growth family, member 2 Neighboring gene NADH:ubiquinone oxidoreductase complex assembly factor 7, pseudogene 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Alternative reading frame protein (ARF)-independent function of CARF (collaborator of ARF) involves its interactions with p53: evidence for a novel p53-activation pathway and its negative feedback control. Hasan MK, et al. Biochem J, 2004 Jun 15. PMID 15109303, Free PMC Article
  2. Collaborator of ARF (CARF) regulates proliferative fate of human cells by dose-dependent regulation of DNA damage signaling. Cheung CT, et al. J Biol Chem, 2014 Jun 27. PMID 24825908, Free PMC Article
  3. A novel putative collaborator of p19ARF. Wadhwa R, et al. Exp Gerontol, 2003 Mar. PMID 12581788
  4. CARF is a novel protein that cooperates with mouse p19ARF (human p14ARF) in activating p53. Hasan MK, et al. J Biol Chem, 2002 Oct 4. PMID 12154087
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

See all (6) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Clone Names

  • MGC112660

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables RNA binding IEA
Inferred from Electronic Annotation
more info
  
enables p53 binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in DNA damage response ISO
Inferred from Sequence Orthology
more info
  
involved_in DNA damage response ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in negative regulation of cell growth ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of cell growth ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of cell growth ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in positive regulation of signal transduction ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of protein stability ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in granular component ISO
Inferred from Sequence Orthology
more info
  
is_active_in nucleolus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleolus ISO
Inferred from Sequence Orthology
more info
  
is_active_in nucleoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
CDKN2A-interacting protein
Names
collaborator of ARF

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001014000.1 → NP_001014022.1  CDKN2A-interacting protein

    See identical proteins and their annotated locations for NP_001014022.1

    Status: PROVISIONAL

    Source sequence(s)
    BC085832
    UniProtKB/Swiss-Prot
    Q4KM89, Q5U2X0
    UniProtKB/TrEMBL
    A0A8I6AJX9, A6JPK7
    Related
    ENSRNOP00000029705.4, ENSRNOT00000030519.6
    Conserved Domains (1) summary
    pfam11952
    Location:19 → 117
    XTBD; XRN-Two Binding Domain, XTBD

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086034.1 Reference GRCr8

    Range
    51266613..51274051
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039094518.2 → XP_038950446.1  CDKN2A-interacting protein isoform X1

    Conserved Domains (1) summary
    pfam11952
    Location:19 → 117
    XTBD; XRN-Two Binding Domain, XTBD

  2. XM_006253147.5 → XP_006253209.1  CDKN2A-interacting protein isoform X2

    See identical proteins and their annotated locations for XP_006253209.1

    UniProtKB/Swiss-Prot
    Q5U2X0
    Conserved Domains (1) summary
    pfam11952
    Location:19 → 117
    XTBD; XRN-Two Binding Domain, XTBD
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q5U2X0.1 GenPept UniProtKB/Swiss-Prot:Q5U2X0

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
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