Cnot7 CCR4-NOT transcription complex, subunit 7 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Cnot7provided by RGD
Official Full Name: CCR4-NOT transcription complex, subunit 7provided by RGD
Primary source: RGD:1305313
See related: Ensembl:ENSRNOG00000012263 AllianceGenome:RGD:1305313
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable DNA-binding transcription factor binding activity; poly(A)-specific ribonuclease activity; and transcription corepressor activity. Predicted to be involved in several processes, including negative regulation of macromolecule metabolic process; negative regulation of type I interferon-mediated signaling pathway; and positive regulation of mRNA catabolic process. Predicted to act upstream of or within P-body assembly and positive regulation of RNA metabolic process. Located in nucleus. Biomarker of male infertility. Orthologous to human CNOT7 (CCR4-NOT transcription complex subunit 7). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Brain (RPKM 153.6), Thymus (RPKM 149.8) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 16q12.1

Exon count:: 9

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	16	NC_086034.1 (58478882..58498046)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	16	NC_051351.1 (51775416..51794581)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	16	NC_005115.4 (54899452..54918616)

Chromosome 16 - NC_086034.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

D16Got55 (e-PCR)
- UniSTS:112645

RH134146 (e-PCR)
- UniSTS:217428

RH141884 (e-PCR)
- UniSTS:223876

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables 3'-5'-RNA exonuclease activity	ISO Inferred from Sequence Orthology more info
enables DNA-binding transcription factor binding	ISO Inferred from Sequence Orthology more info
enables RNA exonuclease activity	ISO Inferred from Sequence Orthology more info
enables nucleic acid binding	IEA Inferred from Electronic Annotation more info
enables poly(A)-specific ribonuclease activity	IBA Inferred from Biological aspect of Ancestor more info
enables poly(A)-specific ribonuclease activity	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables transcription corepressor activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within P-body assembly	ISO Inferred from Sequence Orthology more info
involved_in biological_process	ND No biological Data available more info
acts_upstream_of_or_within deadenylation-dependent decapping of nuclear-transcribed mRNA	ISO Inferred from Sequence Orthology more info
involved_in deadenylation-dependent decapping of nuclear-transcribed mRNA	ISO Inferred from Sequence Orthology more info
involved_in defense response to virus	ISO Inferred from Sequence Orthology more info
involved_in miRNA-mediated gene silencing by mRNA destabilization	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of DNA-templated transcription	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of cell population proliferation	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of gene expression	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of type I interferon-mediated signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within nuclear-transcribed mRNA poly(A) tail shortening	ISO Inferred from Sequence Orthology more info
involved_in nuclear-transcribed mRNA poly(A) tail shortening	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cell population proliferation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of mRNA catabolic process	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of nuclear-transcribed mRNA poly(A) tail shortening	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of viral genome replication	ISO Inferred from Sequence Orthology more info
involved_in regulation of tyrosine phosphorylation of STAT protein	ISO Inferred from Sequence Orthology more info
involved_in regulatory ncRNA-mediated gene silencing	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
part_of CCR4-NOT complex	ISO Inferred from Sequence Orthology more info
part_of CCR4-NOT core complex	IBA Inferred from Biological aspect of Ancestor more info
is_active_in P-body	IBA Inferred from Biological aspect of Ancestor more info
located_in P-body	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
is_active_in intracellular non-membrane-bounded organelle	ISO Inferred from Sequence Orthology more info
located_in nuclear body	ISO Inferred from Sequence Orthology more info
located_in nuclear speck	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: CCR4-NOT transcription complex subunit 7

NP_001100783.1

EC 3.1.13.4

XP_017455614.1

EC 3.1.13.4

XP_017455615.1

EC 3.1.13.4

XP_017455616.1

EC 3.1.13.4

XP_017455617.1

EC 3.1.13.4

XP_038950462.1

EC 3.1.13.4

XP_038950465.1

EC 3.1.13.4

XP_063131501.1

EC 3.1.13.4

XP_063131502.1

EC 3.1.13.4

XP_063131503.1

EC 3.1.13.4

XP_063131504.1

EC 3.1.13.4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001107313.1 → NP_001100783.1 CCR4-NOT transcription complex subunit 7

See identical proteins and their annotated locations for NP_001100783.1

Status: PROVISIONAL

Source sequence(s)

CH473995

UniProtKB/TrEMBL

A6JPV7, B3DMA5, F7F9V0

Related

ENSRNOP00000016882.4, ENSRNOT00000016882.6

Conserved Domains (1) summary

cl23804
Location:1 → 279

CAF1; CAF1 family ribonuclease

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086034.1 Reference GRCr8

Range

58478882..58498046

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_017600125.3 → XP_017455614.1 CCR4-NOT transcription complex subunit 7 isoform X1

Conserved Domains (1) summary

cl23804
Location:1 → 292

CAF1; CAF1 family ribonuclease
XM_039094534.2 → XP_038950462.1 CCR4-NOT transcription complex subunit 7 isoform X3

Conserved Domains (1) summary

cl23804
Location:1 → 228

CAF1; CAF1 family ribonuclease
XM_039094537.2 → XP_038950465.1 CCR4-NOT transcription complex subunit 7 isoform X4

UniProtKB/TrEMBL

A0A8I6AEC4

Related

ENSRNOP00000092791.1

Conserved Domains (1) summary

cl23804
Location:1 → 215

CAF1; CAF1 family ribonuclease
XM_063275432.1 → XP_063131502.1 CCR4-NOT transcription complex subunit 7 isoform X2

UniProtKB/TrEMBL

A6JPV7, B3DMA5, F7F9V0
XM_063275431.1 → XP_063131501.1 CCR4-NOT transcription complex subunit 7 isoform X2

UniProtKB/TrEMBL

A6JPV7, B3DMA5, F7F9V0
XM_017600128.3 → XP_017455617.1 CCR4-NOT transcription complex subunit 7 isoform X1

Conserved Domains (1) summary

cl23804
Location:1 → 292

CAF1; CAF1 family ribonuclease
XM_063275434.1 → XP_063131504.1 CCR4-NOT transcription complex subunit 7 isoform X4

UniProtKB/TrEMBL

A0A8I6AEC4
XM_063275433.1 → XP_063131503.1 CCR4-NOT transcription complex subunit 7 isoform X2

UniProtKB/TrEMBL

A6JPV7, B3DMA5, F7F9V0
XM_017600127.3 → XP_017455616.1 CCR4-NOT transcription complex subunit 7 isoform X1

Conserved Domains (1) summary

cl23804
Location:1 → 292

CAF1; CAF1 family ribonuclease
XM_017600126.3 → XP_017455615.1 CCR4-NOT transcription complex subunit 7 isoform X1

Conserved Domains (1) summary

cl23804
Location:1 → 292

CAF1; CAF1 family ribonuclease