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Akr1c1 aldo-keto reductase family 1, member C1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 307092, updated on 2-Nov-2024

Summary

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Official Symbol
Akr1c1provided by RGD
Official Full Name
aldo-keto reductase family 1, member C1provided by RGD
Primary source
RGD:1306847
See related
EnsemblRapid:ENSRNOG00000038331 AllianceGenome:RGD:1306847
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Akr1c6; Hsd17b5
Summary
Enables 17-alpha,20-alpha-dihydroxypregn-4-en-3-one dehydrogenase activity and testosterone 17-beta-dehydrogenase (NADP+) activity. Involved in response to estrogen and response to xenobiotic stimulus. Located in cytoplasm and nucleus. Human ortholog(s) of this gene implicated in 46,XY sex reversal 8; B-lymphoblastic leukemia/lymphoma; T-cell acute lymphoblastic leukemia; and leukemia. Orthologous to several human genes including AKR1C4 (aldo-keto reductase family 1 member C4). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Restricted expression toward (RPKM 1618.5) See more
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Genomic context

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See Akr1c1 in Genome Data Viewer
Location:
17q12.2
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 17 NC_086035.1 (70720397..70747285, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 17 NC_051352.1 (65810474..65837385, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 17 NC_005116.4 (69441253..69460334, complement)

Chromosome 17 - NC_086035.1Genomic Context describing neighboring genes Neighboring gene serine and arginine rich splicing factor 3, pseudogene 9 Neighboring gene aldo-keto reductase family 1, member C2 Neighboring gene aldo-keto reductase family 1 member C3-like 1 Neighboring gene aldo-keto reductase family 1, member C12-like 1 Neighboring gene voltage-dependent anion channel 1, pseudogene 6

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Molecular cloning of a novel type of rat cytoplasmic 17beta-hydroxysteroid dehydrogenase distinct from the type 5 isozyme. Ishikura S, et al. J Biochem, 2006 Jun. PMID 16788056
  2. Expression and activity of steroid aldoketoreductases 1C in omental adipose tissue are positive correlates of adiposity in women. Blouin K, et al. Am J Physiol Endocrinol Metab, 2005 Feb. PMID 15494612
  3. Tissue distribution of human AKR1C3 and rat homolog in the adult genitourinary system. Azzarello J, et al. J Histochem Cytochem, 2008 Sep. PMID 18574251, Free PMC Article
  4. Molecular cloning and characterization of mouse estradiol 17 beta-dehydrogenase (A-specific), a member of the aldoketoreductase family. Deyashiki Y, et al. J Biol Chem, 1995 May 5. PMID 7737980
  5. AKR1C isoforms represent a novel cellular target for jasmonates alongside their mitochondrial-mediated effects. Davies NJ, et al. Cancer Res, 2009 Jun 1. PMID 19487289

See all (12) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Homology

Clone Names

  • MGC125057

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables 17-alpha,20-alpha-dihydroxypregn-4-en-3-one dehydrogenase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables aldo-keto reductase (NADPH) activity ISO
Inferred from Sequence Orthology
more info
  
enables aldose reductase (NADPH) activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables aldose reductase (NADPH) activity ISO
Inferred from Sequence Orthology
more info
  
enables androsterone dehydrogenase (B-specific) activity ISO
Inferred from Sequence Orthology
more info
  
enables androsterone dehydrogenase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables bile acid binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables bile acid binding ISO
Inferred from Sequence Orthology
more info
  
enables carboxylic acid binding ISO
Inferred from Sequence Orthology
more info
  
enables estradiol 17-beta-dehydrogenase [NAD(P)+] activity ISO
Inferred from Sequence Orthology
more info
  
enables ketosteroid monooxygenase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables ketosteroid monooxygenase activity ISO
Inferred from Sequence Orthology
more info
  
enables oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor ISO
Inferred from Sequence Orthology
more info
  
enables testosterone 17-beta-dehydrogenase (NADP+) activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables trans-1,2-dihydrobenzene-1,2-diol dehydrogenase activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in bile acid metabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in cellular response to jasmonic acid stimulus ISO
Inferred from Sequence Orthology
more info
  
involved_in daunorubicin metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in daunorubicin metabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in digestion ISO
Inferred from Sequence Orthology
more info
  
involved_in doxorubicin metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in doxorubicin metabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in epithelial cell differentiation ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within negative regulation of mRNA splicing, via spliceosome ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of reactive oxygen species metabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in progesterone metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in progesterone metabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in prostaglandin metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in response to estrogen IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in response to organophosphorus ISO
Inferred from Sequence Orthology
more info
  
involved_in response to xenobiotic stimulus IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in retinal metabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in steroid biosynthetic process ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within steroid metabolic process ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
aldo-keto reductase family 1, member C1
Names
20-alpha (3-alpha)-hydroxysteroid dehydrogenase)
aldo-keto reductase family 1, member C1 (dihydrodiol dehydrogenase 1
aldo-keto reductase family 1, member C1 (dihydrodiol dehydrogenase 1; 20-alpha (3-alpha)-hydroxysteroid dehydrogenase)
aldo-keto reductase family 1, member C6
type 5 17beta-hydroxysteroid dehydrogenase
NP_001028869.1
XP_006254250.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001033697.1 → NP_001028869.1  aldo-keto reductase family 1, member C1

    See identical proteins and their annotated locations for NP_001028869.1

    Status: PROVISIONAL

    Source sequence(s)
    BC104716
    UniProtKB/TrEMBL
    Q3MHS3, Q5I0L1
    Related
    ENSRNOP00000055169.2, ENSRNOT00000058367.5
    Conserved Domains (2) summary
    COG0656
    Location:5 → 305
    ARA1; Aldo/keto reductase, related to diketogulonate reductase [Secondary metabolites biosynthesis, transport and catabolism]
    COG0667
    Location:16 → 297
    Tas; Predicted oxidoreductase (related to aryl-alcohol dehydrogenase) [General function prediction only]

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086035.1 Reference GRCr8

    Range
    70720397..70747285 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006254188.5 → XP_006254250.1  aldo-keto reductase family 1, member C1 isoform X1

    UniProtKB/TrEMBL
    A0A8I6AV33
    Conserved Domains (2) summary
    COG0656
    Location:5 → 283
    ARA1; Aldo/keto reductase, related to diketogulonate reductase [Secondary metabolites biosynthesis, transport and catabolism]
    COG0667
    Location:16 → 282
    Tas; Predicted oxidoreductase (related to aryl-alcohol dehydrogenase) [General function prediction only]
Nucleotide Protein Strain
Heading Accession and Version

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