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Mcm10 minichromosome maintenance 10 replication initiation factor [ Rattus norvegicus (Norway rat) ]

Gene ID: 307126, updated on 28-Oct-2024

Summary

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Official Symbol
Mcm10provided by RGD
Official Full Name
minichromosome maintenance 10 replication initiation factorprovided by RGD
Primary source
RGD:1311330
See related
EnsemblRapid:ENSRNOG00000017981 AllianceGenome:RGD:1311330
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable DNA binding activity; enzyme binding activity; and identical protein binding activity. Predicted to be involved in DNA damage response and DNA replication initiation. Predicted to act upstream of or within cell population proliferation. Predicted to be located in nucleolus and nucleoplasm. Predicted to be active in nuclear replication fork. Human ortholog(s) of this gene implicated in primary immunodeficiency disease. Orthologous to human MCM10 (minichromosome maintenance 10 replication initiation factor). [provided by Alliance of Genome Resources, Oct 2024]
Expression
Biased expression in Thymus (RPKM 73.3), Spleen (RPKM 41.9) and 7 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Mcm10 in Genome Data Viewer
Location:
17q12.3
Exon count:
22
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 17 NC_086035.1 (78172049..78197644)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 17 NC_051352.1 (73263788..73288346)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 17 NC_005116.4 (77224218..77245486)

Chromosome 17 - NC_086035.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC108348590 Neighboring gene optineurin Neighboring gene uncharacterized LOC134482742 Neighboring gene upper zone of growth plate and cartilage matrix associated Neighboring gene phytanoyl-CoA 2-hydroxylase

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Targeted disruption of Mcm10 causes defective embryonic cell proliferation and early embryo lethality. Lim HJ, et al. Biochim Biophys Acta, 2011 Oct. PMID 21693137
  2. Hexameric ring structure of human MCM10 DNA replication factor. Okorokov AL, et al. EMBO Rep, 2007 Oct. PMID 17823614, Free PMC Article
  3. The RBBP6/ZBTB38/MCM10 axis regulates DNA replication and common fragile site stability. Miotto B, et al. Cell Rep, 2014 Apr 24. PMID 24726359
  4. The human homolog of Saccharomyces cerevisiae Mcm10 interacts with replication factors and dissociates from nuclease-resistant nuclear structures in G(2) phase. Izumi M, et al. Nucleic Acids Res, 2000 Dec 1. PMID 11095689, Free PMC Article
  5. RTEL1 is a replisome-associated helicase that promotes telomere and genome-wide replication. Vannier JB, et al. Science, 2013 Oct 11. PMID 24115439

See all (6) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables DNA replication origin binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables enzyme binding ISO
Inferred from Sequence Orthology
more info
  
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables single-stranded DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in DNA damage response ISO
Inferred from Sequence Orthology
more info
  
involved_in DNA replication initiation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in DNA replication initiation ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within cell population proliferation ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
is_active_in nuclear replication fork IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleolus IEA
Inferred from Electronic Annotation
more info
  
located_in nucleolus ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
protein MCM10 homolog
Names
minichromosome maintenance complex component 10
minichromosome maintenance deficient 10

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001107366.1 → NP_001100836.1  protein MCM10 homolog

    See identical proteins and their annotated locations for NP_001100836.1

    Status: PROVISIONAL

    Source sequence(s)
    CH473990
    UniProtKB/TrEMBL
    A6JLZ2, D3Z8C4
    Related
    ENSRNOP00000024178.5, ENSRNOT00000024178.8
    Conserved Domains (2) summary
    pfam09329
    Location:402 → 447
    zf-primase; Primase zinc finger
    pfam09332
    Location:545 → 887
    Mcm10; Mcm10 replication factor

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086035.1 Reference GRCr8

    Range
    78172049..78197644
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039095781.2 → XP_038951709.1  protein MCM10 homolog isoform X1

    Related
    ENSRNOP00000103505.1, ENSRNOT00000148655.1
    Conserved Domains (3) summary
    PHA03247
    Location:87 → 283
    PHA03247; large tegument protein UL36; Provisional
    pfam09329
    Location:346 → 391
    zf-primase; Primase zinc finger
    pfam09332
    Location:492 → 831
    Mcm10; Mcm10 replication factor

  2. XM_063276495.1 → XP_063132565.1  protein MCM10 homolog isoform X2

  3. XM_039095782.2 → XP_038951710.1  protein MCM10 homolog isoform X3

    Conserved Domains (2) summary
    pfam09329
    Location:46 → 91
    zf-primase; Primase zinc finger
    pfam09332
    Location:192 → 531
    Mcm10; Mcm10 replication factor
Nucleotide Protein Strain
Heading Accession and Version

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