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Ark2c arkadia C-terminal like ring finger ubiquitin ligase 2C [ Rattus norvegicus (Norway rat) ]

Gene ID: 307251, updated on 2-Nov-2024

Summary

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Official Symbol
Ark2cprovided by RGD
Official Full Name
arkadia C-terminal like ring finger ubiquitin ligase 2Cprovided by RGD
Primary source
RGD:1560744
See related
EnsemblRapid:ENSRNOG00000048824 AllianceGenome:RGD:1560744
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Rnf165; RGD1560744
Summary
Predicted to enable ubiquitin protein ligase activity. Predicted to be involved in motor neuron axon guidance and positive regulation of BMP signaling pathway. Predicted to act upstream of or within several processes, including forelimb morphogenesis; nervous system development; and protein polyubiquitination. Predicted to be part of protein-containing complex. Predicted to be active in nucleus. Orthologous to human ARK2C (arkadia (RNF111) C-terminal like ring finger ubiquitin ligase 2C). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Brain (RPKM 21.4), Adrenal (RPKM 3.3) and 1 other tissue See more
Orthologs
human mouse all
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Genomic context

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See Ark2c in Genome Data Viewer
Location:
18q12.3
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 18 NC_086036.1 (73259736..73375987, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 18 NC_051353.1 (70984566..71100836, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 18 NC_005117.4 (73831289..73873246, complement)

Chromosome 18 - NC_086036.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC102551787 Neighboring gene lipoxygenase homology PLAT domains 1 Neighboring gene uncharacterized protein DDB_G0292186-like Neighboring gene uncharacterized LOC108348739 Neighboring gene uncharacterized LOC102551968

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Rnf165/Ark2C enhances BMP-Smad signaling to mediate motor axon extension. Kelly CE, et al. PLoS Biol, 2013. PMID 23610558, Free PMC Article
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
  3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables ubiquitin protein ligase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables ubiquitin protein ligase activity ISO
Inferred from Sequence Orthology
more info
  
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within axonogenesis ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within forelimb morphogenesis ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within innervation ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within limb development ISO
Inferred from Sequence Orthology
more info
  
involved_in motor neuron axon guidance IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within motor neuron axon guidance ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within muscle structure development ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of BMP signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within positive regulation of BMP signaling pathway ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within protein catabolic process ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within protein polyubiquitination ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  
part_of protein-containing complex ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
E3 ubiquitin-protein ligase ARK2C
Names
E3 ubiquitin-protein ligase RNF165
ring finger protein 165
NP_001157977.1
XP_038952706.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001164505.2 → NP_001157977.1  E3 ubiquitin-protein ligase ARK2C

    See identical proteins and their annotated locations for NP_001157977.1

    Status: VALIDATED

    Source sequence(s)
    BC166566
    UniProtKB/TrEMBL
    A0A8I5ZSL4, B2GV81, M0RCK2
    Related
    ENSRNOP00000067322.2, ENSRNOT00000075580.4
    Conserved Domains (2) summary
    pfam07573
    Location:30 → 84
    AreA_N; Nitrogen regulatory protein AreA N terminus
    pfam13639
    Location:296 → 337
    zf-RING_2; Ring finger domain

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086036.1 Reference GRCr8

    Range
    73259736..73375987 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039096778.2 → XP_038952706.1  E3 ubiquitin-protein ligase ARK2C isoform X1

    UniProtKB/TrEMBL
    A6KMV1
    Conserved Domains (1) summary
    cd16474
    Location:227 → 272
    RING-H2_RNF111_like; RING finger, H2 subclass, found in RING finger proteins RNF111, RNF165, and similar proteins
Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

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