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Piezo2 piezo-type mechanosensitive ion channel component 2 [ Rattus norvegicus (Norway rat) ]

Gene ID: 307380, updated on 17-Aug-2024

Summary

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Official Symbol
Piezo2provided by RGD
Official Full Name
piezo-type mechanosensitive ion channel component 2provided by RGD
Primary source
RGD:1582973
See related
EnsemblRapid:ENSRNOG00000038784 AllianceGenome:RGD:1582973
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Fam38b; RGD1306866
Summary
Predicted to enable mechanosensitive cation channel activity. Predicted to be involved in cellular response to mechanical stimulus; detection of mechanical stimulus involved in sensory perception; and regulation of membrane potential. Predicted to act upstream of or within cation transport. Predicted to be integral component of membrane. Predicted to be active in plasma membrane. Human ortholog(s) of this gene implicated in distal arthrogryposis type 3 and distal arthrogryposis type 5. Orthologous to human PIEZO2 (piezo type mechanosensitive ion channel component 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Lung (RPKM 132.6), Adrenal (RPKM 51.4) and 7 other tissues See more
Orthologs
human mouse all
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Genomic context

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Location:
18q12.1
Exon count:
55
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 18 NC_086036.1 (58738734..59115252, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 18 NC_051353.1 (56468449..56844984, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 18 NC_005117.4 (58353361..58728555, complement)

Chromosome 18 - NC_086036.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134483041 Neighboring gene NSF attachment protein gamma Neighboring gene transfer RNA alanine (anticodon GGC) 5 Neighboring gene uncharacterized LOC134482983

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Upregulation of Piezo2 in the mesangial, renin, and perivascular mesenchymal cells of the kidney of Dahl salt-sensitive hypertensive rats and its reversal by esaxerenone. Ochiai K, et al. Hypertens Res, 2023 May. PMID 36810623
  2. Significance of piezo-type mechanosensitive ion channel component 2 in premature ejaculation: An animal study. Chen Z, et al. Andrology, 2020 Sep. PMID 32100938
  3. The potential role of Piezo2 in the mediation of visceral sensation. Yang J, et al. Neurosci Lett, 2016 Sep 6. PMID 27481627
  4. Regulation of Piezo2 Mechanotransduction by Static Plasma Membrane Tension in Primary Afferent Neurons. Jia Z, et al. J Biol Chem, 2016 Apr 22. PMID 26929410, Free PMC Article
  5. Piezo2 channel conductance and localization domains in Merkel cells of rat whisker hair follicles. Ikeda R, et al. Neurosci Lett, 2014 Nov 7. PMID 24911969

See all (12) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Piezo2 Channel Upregulation is Involved in Mechanical Allodynia in CYP-Induced Cystitis Rats.
    Title: Piezo2 Channel Upregulation is Involved in Mechanical Allodynia in CYP-Induced Cystitis Rats.
  2. Upregulation of Piezo2 in the mesangial, renin, and perivascular mesenchymal cells of the kidney of Dahl salt-sensitive hypertensive rats and its reversal by esaxerenone.
    Title: Upregulation of Piezo2 in the mesangial, renin, and perivascular mesenchymal cells of the kidney of Dahl salt-sensitive hypertensive rats and its reversal by esaxerenone.
  3. Loss of lung microvascular endothelial Piezo2 expression impairs NO synthesis, induces EndMT, and is associated with pulmonary hypertension.
    Title: Loss of lung microvascular endothelial Piezo2 expression impairs NO synthesis, induces EndMT, and is associated with pulmonary hypertension.
  4. Significance of piezo-type mechanosensitive ion channel component 2 in premature ejaculation: An animal study.
    Title: Significance of piezo-type mechanosensitive ion channel component 2 in premature ejaculation: An animal study.
  5. The effect of IL-6/Piezo2 on the trigeminal neuropathic pain.
    Title: The effect of IL-6/Piezo2 on the trigeminal neuropathic pain.
  6. Piezo2 knock-down in dorsal root ganglia attenuated visceral sensation to innocuous stimuli in control rats and to both innocuous and noxious stimuli in rats with neonatal irritation. Data suggest a potential role of Piezo2 in the mediation of visceral sensation.
    Title: The potential role of Piezo2 in the mediation of visceral sensation.
  7. findings suggest that Piezo2-mediated mechanotransduction is regulated by SPMT in primary afferent neurons.
    Title: Regulation of Piezo2 Mechanotransduction by Static Plasma Membrane Tension in Primary Afferent Neurons.
  8. Piezo2 channels are preferentially located on Merkel cell processes, the membrane domains inaccessible by recording electrodes
    Title: Piezo2 channel conductance and localization domains in Merkel cells of rat whisker hair follicles.
  9. These findings revealed a GTP-dependent up-regulation of the function of piezo2 ion channels in dorsal root ganglion neurons.
    Title: GTP-dependent run-up of Piezo2-type mechanically activated currents in rat dorsal root ganglion neurons.
  10. Using rat whisker hair follicles, study shows that Merkel cells rather than Abeta-afferent nerve endings are primary sites of tactile transduction and identify the Piezo2 ion channel as the Merkel cell mechanical transducer. Piezo2 transduces tactile stimuli into Ca2+-action potentials in Merkel cells, which drive Abeta-afferent nerve endings to fire slowly adapting impulses.
    Title: Merkel cells transduce and encode tactile stimuli to drive Aβ-afferent impulses.
Submit: New GeneRIF Correction

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables mechanosensitive monoatomic ion channel activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables mechanosensitive monoatomic ion channel activity ISO
Inferred from Sequence Orthology
more info
  
enables monoatomic cation channel activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables monoatomic cation channel activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in cellular response to mechanical stimulus IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in detection of mechanical stimulus IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in detection of mechanical stimulus involved in sensory perception ISO
Inferred from Sequence Orthology
more info
  
involved_in monoatomic cation transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
involved_in monoatomic cation transport ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of membrane potential IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within regulation of membrane potential ISO
Inferred from Sequence Orthology
more info
  
involved_in response to mechanical stimulus ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
piezo-type mechanosensitive ion channel component 2
Names
family with sequence similarity 38, member B
protein PIEZO2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001427318.1 → NP_001414247.1  piezo-type mechanosensitive ion channel component 2

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000018
    UniProtKB/TrEMBL
    F1M208

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086036.1 Reference GRCr8

    Range
    58738734..59115252 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063277327.1 → XP_063133397.1  piezo-type mechanosensitive ion channel component 2 isoform X7

    UniProtKB/TrEMBL
    F1M208

  2. XM_039097390.2 → XP_038953318.1  piezo-type mechanosensitive ion channel component 2 isoform X3

    UniProtKB/TrEMBL
    F1M208
    Related
    ENSRNOP00000084685.2, ENSRNOT00000107888.2
    Conserved Domains (2) summary
    pfam12166
    Location:2378 → 2787
    Piezo_RRas_bdg; Piezo non-specific cation channel, R-Ras-binding domain
    pfam15917
    Location:1349 → 1583
    PIEZO; Piezo

  3. XM_039097388.2 → XP_038953316.1  piezo-type mechanosensitive ion channel component 2 isoform X1

    UniProtKB/TrEMBL
    A0A8I5ZZN0
    Conserved Domains (2) summary
    pfam12166
    Location:2397 → 2806
    Piezo_RRas_bdg; Piezo non-specific cation channel, R-Ras-binding domain
    pfam15917
    Location:1368 → 1602
    PIEZO; Piezo

  4. XM_225880.11 → XP_225880.5  piezo-type mechanosensitive ion channel component 2 isoform X5

    See identical proteins and their annotated locations for XP_225880.5

    UniProtKB/TrEMBL
    A0A8I5ZZN0, A0A8I6A0I2
    Related
    ENSRNOP00000025552.4, ENSRNOT00000025556.7
    Conserved Domains (2) summary
    pfam12166
    Location:2340 → 2749
    Piezo_RRas_bdg; Piezo non-specific cation channel, R-Ras-binding domain
    pfam15917
    Location:1367 → 1598
    PIEZO; Piezo

  5. XM_039097389.2 → XP_038953317.1  piezo-type mechanosensitive ion channel component 2 isoform X2

    UniProtKB/TrEMBL
    A0A8I5ZZN0
    Related
    ENSRNOP00000085065.2, ENSRNOT00000102225.2
    Conserved Domains (2) summary
    pfam12166
    Location:2396 → 2805
    Piezo_RRas_bdg; Piezo non-specific cation channel, R-Ras-binding domain
    pfam15917
    Location:1367 → 1601
    PIEZO; Piezo

  6. XM_039097391.2 → XP_038953319.1  piezo-type mechanosensitive ion channel component 2 isoform X4

    UniProtKB/TrEMBL
    F1M208
    Related
    ENSRNOP00000063723.4, ENSRNOT00000065693.6
    Conserved Domains (2) summary
    pfam12166
    Location:2354 → 2763
    Piezo_RRas_bdg; Piezo non-specific cation channel, R-Ras-binding domain
    pfam15917
    Location:1381 → 1615
    PIEZO; Piezo

  7. XM_039097392.2 → XP_038953320.1  piezo-type mechanosensitive ion channel component 2 isoform X6

    Conserved Domains (2) summary
    pfam12166
    Location:1514 → 1923
    Piezo_RRas_bdg; Piezo non-specific cation channel, R-Ras-binding domain
    pfam15917
    Location:485 → 719
    PIEZO; Piezo

RNA

  1. XR_005496481.2 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version

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