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Fbxo38 F-box protein 38 [ Rattus norvegicus (Norway rat) ]

Gene ID: 307390, updated on 2-Nov-2024

Summary

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Official Symbol
Fbxo38provided by RGD
Official Full Name
F-box protein 38provided by RGD
Primary source
RGD:1311505
See related
EnsemblRapid:ENSRNOG00000019063 AllianceGenome:RGD:1311505
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable ubiquitin-like ligase-substrate adaptor activity. Predicted to be involved in several processes, including SCF-dependent proteasomal ubiquitin-dependent protein catabolic process; positive regulation of T cell mediated immune response to tumor cell; and protein K48-linked ubiquitination. Predicted to act upstream of or within positive regulation of neuron projection development. Predicted to be active in cytoplasm and nucleus. Human ortholog(s) of this gene implicated in autosomal dominant distal hereditary motor neuronopathy 6. Orthologous to human FBXO38 (F-box protein 38). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Lung (RPKM 134.5), Thymus (RPKM 129.5) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Fbxo38 in Genome Data Viewer
Location:
18q12.1
Exon count:
23
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 18 NC_086036.1 (58227253..58274320, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 18 NC_051353.1 (55956950..56004013, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 18 NC_005117.4 (57827391..57874515, complement)

Chromosome 18 - NC_086036.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC102556293 Neighboring gene uncharacterized LOC108348797 Neighboring gene 5-hydroxytryptamine receptor 4 Neighboring gene uncharacterized LOC120098287 Neighboring gene uncharacterized LOC134483040 Neighboring gene serine protease inhibitor Kazal-type 9-like Neighboring gene serine peptidase inhibitor, Kazal type 7

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Multiple pathways regulate intracellular shuttling of MoKA, a co-activator of transcription factor KLF7. Smaldone S, et al. Nucleic Acids Res, 2006. PMID 16990251, Free PMC Article
  2. FBXO38 mediates PD-1 ubiquitination and regulates anti-tumour immunity of T cells. Meng X, et al. Nature, 2018 Dec. PMID 30487606
  3. Normalization and subtraction: two approaches to facilitate gene discovery. Bonaldo MF, et al. Genome Res, 1996 Sep. PMID 8889548
  4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables ubiquitin-like ligase-substrate adaptor activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in SCF-dependent proteasomal ubiquitin-dependent protein catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in SCF-dependent proteasomal ubiquitin-dependent protein catabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of T cell activation ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of T cell mediated immune response to tumor cell ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of neuron projection development IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within positive regulation of neuron projection development ISO
Inferred from Sequence Orthology
more info
  
involved_in protein K48-linked ubiquitination IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein K48-linked ubiquitination ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
F-box only protein 38

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001372021.1 → NP_001358950.1  F-box only protein 38

    Status: VALIDATED

    Source sequence(s)
    BQ781227, JAXUCZ010000018
    UniProtKB/TrEMBL
    D3ZIK8
    Related
    ENSRNOP00000025791.6, ENSRNOT00000025790.9
    Conserved Domains (1) summary
    pfam00646
    Location:32 → 65
    F-box; F-box domain

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086036.1 Reference GRCr8

    Range
    58227253..58274320 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063277340.1 → XP_063133410.1  F-box only protein 38 isoform X7

  2. XM_063277335.1 → XP_063133405.1  F-box only protein 38 isoform X5

  3. XM_006254822.5 → XP_006254884.1  F-box only protein 38 isoform X1

    See identical proteins and their annotated locations for XP_006254884.1

    UniProtKB/TrEMBL
    D3ZIK8
    Conserved Domains (1) summary
    pfam00646
    Location:32 → 65
    F-box; F-box domain

  4. XM_063277332.1 → XP_063133402.1  F-box only protein 38 isoform X4

  5. XM_063277337.1 → XP_063133407.1  F-box only protein 38 isoform X6

  6. XM_063277329.1 → XP_063133399.1  F-box only protein 38 isoform X2

  7. XM_063277330.1 → XP_063133400.1  F-box only protein 38 isoform X2

  8. XM_063277339.1 → XP_063133409.1  F-box only protein 38 isoform X6

  9. XM_063277334.1 → XP_063133404.1  F-box only protein 38 isoform X5

  10. XM_006254821.5 → XP_006254883.1  F-box only protein 38 isoform X1

    See identical proteins and their annotated locations for XP_006254883.1

    UniProtKB/TrEMBL
    D3ZIK8
    Conserved Domains (1) summary
    pfam00646
    Location:32 → 65
    F-box; F-box domain

  11. XM_063277341.1 → XP_063133411.1  F-box only protein 38 isoform X7

  12. XM_063277333.1 → XP_063133403.1  F-box only protein 38 isoform X4

  13. XM_063277338.1 → XP_063133408.1  F-box only protein 38 isoform X6

  14. XM_063277331.1 → XP_063133401.1  F-box only protein 38 isoform X2

  15. XM_063277336.1 → XP_063133406.1  F-box only protein 38 isoform X5

  16. XM_039096816.1 → XP_038952744.1  F-box only protein 38 isoform X4

    Conserved Domains (1) summary
    pfam00646
    Location:32 → 65
    F-box; F-box domain

  17. XM_039096815.1 → XP_038952743.1  F-box only protein 38 isoform X3

    Conserved Domains (1) summary
    pfam00646
    Location:32 → 65
    F-box; F-box domain

  18. XM_006254825.4 → XP_006254887.1  F-box only protein 38 isoform X6

    See identical proteins and their annotated locations for XP_006254887.1

    Conserved Domains (1) summary
    pfam00646
    Location:32 → 65
    F-box; F-box domain

  19. XM_006254823.4 → XP_006254885.1  F-box only protein 38 isoform X2

    See identical proteins and their annotated locations for XP_006254885.1

    UniProtKB/TrEMBL
    D3ZIK8
    Conserved Domains (1) summary
    pfam00646
    Location:32 → 65
    F-box; F-box domain

  20. XM_006254819.4 → XP_006254881.1  F-box only protein 38 isoform X1

    See identical proteins and their annotated locations for XP_006254881.1

    UniProtKB/TrEMBL
    D3ZIK8
    Conserved Domains (1) summary
    pfam00646
    Location:32 → 65
    F-box; F-box domain

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001107385.1: Suppressed sequence

    Description
    NM_001107385.1: This RefSeq was suppressed temporarily based on the calculation that the encoded protein was shorter than proteins from the putative ortholog from human: FBXO38 (GeneID:81545).
Nucleotide Protein Strain
Heading Accession and Version

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