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Arhgef37 Rho guanine nucleotide exchange factor 37 [ Rattus norvegicus (Norway rat) ]

Gene ID: 307398, updated on 10-Jul-2024

Summary

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Official Symbol
Arhgef37provided by RGD
Official Full Name
Rho guanine nucleotide exchange factor 37provided by RGD
Primary source
RGD:1560471
See related
EnsemblRapid:ENSRNOG00000025502 AllianceGenome:RGD:1560471
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
RGD1560471
Summary
Predicted to enable guanyl-nucleotide exchange factor activity. Predicted to be involved in regulation of catalytic activity. Predicted to be located in cytoplasm. Orthologous to human ARHGEF37 (Rho guanine nucleotide exchange factor 37). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Muscle (RPKM 53.8), Heart (RPKM 49.1) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Arhgef37 in Genome Data Viewer
Location:
18q12.1
Exon count:
21
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 18 NC_086036.1 (57205621..57271284, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 18 NC_051353.1 (54935256..55001017, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 18 NC_005117.4 (56817986..56871159, complement)

Chromosome 18 - NC_086036.1Genomic Context describing neighboring genes Neighboring gene PPARG coactivator 1 beta Neighboring gene microRNA 3557 Neighboring gene microRNA 378 Neighboring gene U6 spliceosomal RNA Neighboring gene casein kinase 1, alpha 1 Neighboring gene ribosomal protein S23, pseudogene 2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
  2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables guanyl-nucleotide exchange factor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables guanyl-nucleotide exchange factor activity IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in synapse IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
rho guanine nucleotide exchange factor 37
Names
Rho guanine nucleotide exchange factor (GEF) 37
probable guanine nucleotide exchange factor FLJ41603 homolog
protein 2-88
scaffold protein tuba 3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001100974.2 → NP_001094444.2  rho guanine nucleotide exchange factor 37

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000018
    UniProtKB/Swiss-Prot
    A1IGU3
    UniProtKB/TrEMBL
    F1LQ74
    Related
    ENSRNOP00000037964.2, ENSRNOT00000032189.5
    Conserved Domains (4) summary
    cd07589
    Location:264 → 452
    BAR_DNMBP; The Bin/Amphiphysin/Rvs (BAR) domain of Dynamin Binding Protein
    cd11799
    Location:510 → 563
    SH3_ARHGEF37_C1; First C-terminal Src homology 3 domain of Rho guanine nucleotide exchange factor 37
    cd11941
    Location:607 → 663
    SH3_ARHGEF37_C2; Second C-terminal Src homology 3 domain of Rho guanine nucleotide exchange factor 37
    pfam00621
    Location:34 → 211
    RhoGEF; RhoGEF domain

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086036.1 Reference GRCr8

    Range
    57205621..57271284 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006254811.5 → XP_006254873.1  rho guanine nucleotide exchange factor 37 isoform X1

    See identical proteins and their annotated locations for XP_006254873.1

    UniProtKB/Swiss-Prot
    A1IGU3
    UniProtKB/TrEMBL
    F1LQ74
    Conserved Domains (4) summary
    cd07589
    Location:264 → 452
    BAR_DNMBP; The Bin/Amphiphysin/Rvs (BAR) domain of Dynamin Binding Protein
    cd11799
    Location:510 → 563
    SH3_ARHGEF37_C1; First C-terminal Src homology 3 domain of Rho guanine nucleotide exchange factor 37
    cd11941
    Location:607 → 663
    SH3_ARHGEF37_C2; Second C-terminal Src homology 3 domain of Rho guanine nucleotide exchange factor 37
    pfam00621
    Location:34 → 211
    RhoGEF; RhoGEF domain

  2. XM_039096828.2 → XP_038952756.1  rho guanine nucleotide exchange factor 37 isoform X1

    UniProtKB/Swiss-Prot
    A1IGU3
    UniProtKB/TrEMBL
    F1LQ74
    Conserved Domains (4) summary
    cd07589
    Location:264 → 452
    BAR_DNMBP; The Bin/Amphiphysin/Rvs (BAR) domain of Dynamin Binding Protein
    cd11799
    Location:510 → 563
    SH3_ARHGEF37_C1; First C-terminal Src homology 3 domain of Rho guanine nucleotide exchange factor 37
    cd11941
    Location:607 → 663
    SH3_ARHGEF37_C2; Second C-terminal Src homology 3 domain of Rho guanine nucleotide exchange factor 37
    pfam00621
    Location:34 → 211
    RhoGEF; RhoGEF domain

  3. XM_006254809.4 → XP_006254871.1  rho guanine nucleotide exchange factor 37 isoform X1

    See identical proteins and their annotated locations for XP_006254871.1

    UniProtKB/Swiss-Prot
    A1IGU3
    UniProtKB/TrEMBL
    F1LQ74
    Conserved Domains (4) summary
    cd07589
    Location:264 → 452
    BAR_DNMBP; The Bin/Amphiphysin/Rvs (BAR) domain of Dynamin Binding Protein
    cd11799
    Location:510 → 563
    SH3_ARHGEF37_C1; First C-terminal Src homology 3 domain of Rho guanine nucleotide exchange factor 37
    cd11941
    Location:607 → 663
    SH3_ARHGEF37_C2; Second C-terminal Src homology 3 domain of Rho guanine nucleotide exchange factor 37
    pfam00621
    Location:34 → 211
    RhoGEF; RhoGEF domain

  4. XM_039096832.2 → XP_038952760.1  rho guanine nucleotide exchange factor 37 isoform X2

    Conserved Domains (3) summary
    cd07589
    Location:50 → 238
    BAR_DNMBP; The Bin/Amphiphysin/Rvs (BAR) domain of Dynamin Binding Protein
    cd11799
    Location:296 → 349
    SH3_ARHGEF37_C1; First C-terminal Src homology 3 domain of Rho guanine nucleotide exchange factor 37
    cd11941
    Location:393 → 449
    SH3_ARHGEF37_C2; Second C-terminal Src homology 3 domain of Rho guanine nucleotide exchange factor 37

  5. XM_063277355.1 → XP_063133425.1  rho guanine nucleotide exchange factor 37 isoform X2

  6. XM_039096833.2 → XP_038952761.1  rho guanine nucleotide exchange factor 37 isoform X2

    Conserved Domains (3) summary
    cd07589
    Location:50 → 238
    BAR_DNMBP; The Bin/Amphiphysin/Rvs (BAR) domain of Dynamin Binding Protein
    cd11799
    Location:296 → 349
    SH3_ARHGEF37_C1; First C-terminal Src homology 3 domain of Rho guanine nucleotide exchange factor 37
    cd11941
    Location:393 → 449
    SH3_ARHGEF37_C2; Second C-terminal Src homology 3 domain of Rho guanine nucleotide exchange factor 37

  7. XM_039096835.2 → XP_038952763.1  rho guanine nucleotide exchange factor 37 isoform X3

    Conserved Domains (3) summary
    cd07589
    Location:3 → 164
    BAR_DNMBP; The Bin/Amphiphysin/Rvs (BAR) domain of Dynamin Binding Protein
    cd11799
    Location:222 → 275
    SH3_ARHGEF37_C1; First C-terminal Src homology 3 domain of Rho guanine nucleotide exchange factor 37
    cd11941
    Location:319 → 375
    SH3_ARHGEF37_C2; Second C-terminal Src homology 3 domain of Rho guanine nucleotide exchange factor 37

RNA

  1. XR_010059573.1 RNA Sequence

  2. XR_010059575.1 RNA Sequence

  3. XR_010059572.1 RNA Sequence

  4. XR_010059574.1 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
A1IGU3.1 GenPept UniProtKB/Swiss-Prot:A1IGU3

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