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Tnfaip8 TNF alpha induced protein 8 [ Rattus norvegicus (Norway rat) ]

Gene ID: 307428, updated on 17-Aug-2024

Summary

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Official Symbol
Tnfaip8provided by RGD
Official Full Name
TNF alpha induced protein 8provided by RGD
Primary source
RGD:1305908
See related
EnsemblRapid:ENSRNOG00000026136 AllianceGenome:RGD:1305908
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable cysteine-type endopeptidase inhibitor activity involved in apoptotic process. Predicted to be involved in positive regulation of apoptotic process. Predicted to act upstream of or within defense response to Gram-positive bacterium. Predicted to be located in nucleoplasm. Predicted to be active in cytoplasm. Orthologous to human TNFAIP8 (TNF alpha induced protein 8). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Spleen (RPKM 129.3), Thymus (RPKM 124.8) and 8 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Tnfaip8 in Genome Data Viewer
Location:
18q11
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 18 NC_086036.1 (45370334..45486036)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 18 NC_051353.1 (43183854..43299512)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 18 NC_005117.4 (44664310..44779914)

Chromosome 18 - NC_086036.1Genomic Context describing neighboring genes Neighboring gene Dmx-like 1 Neighboring gene uncharacterized LOC120098294 Neighboring gene uncharacterized LOC120098293 Neighboring gene hydroxysteroid (17-beta) dehydrogenase 4 Neighboring gene uncharacterized LOC120098292 Neighboring gene family with sequence similarity 170, member A

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. MiR-379 relieves myocardial injury after acute myocardial infarction by regulating tumor necrosis factor-α-induced protein 8. Dai H, et al. Panminerva Med, 2022 Mar. PMID 32414226
  2. Expression and regulation of a novel identified TNFAIP8 family is associated with diabetic nephropathy. Zhang S, et al. Biochim Biophys Acta, 2010 Nov. PMID 20699119
  3. Expression of SCC-S2, an antiapoptotic molecule, correlates with enhanced proliferation and tumorigenicity of MDA-MB 435 cells. Kumar D, et al. Oncogene, 2004 Jan 15. PMID 14724590
  4. Identification of a novel tumor necrosis factor-alpha-inducible gene, SCC-S2, containing the consensus sequence of a death effector domain of fas-associated death domain-like interleukin- 1beta-converting enzyme-inhibitory protein. Kumar D, et al. J Biol Chem, 2000 Jan 28. PMID 10644768
  5. Two genes on A/J chromosome 18 are associated with susceptibility to Staphylococcus aureus infection by combined microarray and QTL analyses. Ahn SH, et al. PLoS Pathog, 2010 Sep 2. PMID 20824097, Free PMC Article

See all (6) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. MiR-379 relieves myocardial injury after acute myocardial infarction by regulating tumor necrosis factor-alpha-induced protein 8.
    Title: MiR-379 relieves myocardial injury after acute myocardial infarction by regulating tumor necrosis factor-α-induced protein 8.
  2. Findings demonstrate that TNFAIP8 is one of critical components of a signal transduction pathway that links mesangial cell proliferation to diabetic renal injury.
    Title: Expression and regulation of a novel identified TNFAIP8 family is associated with diabetic nephropathy.
Submit: New GeneRIF Correction

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables cysteine-type endopeptidase inhibitor activity involved in apoptotic process IBA
Inferred from Biological aspect of Ancestor
more info
  
enables cysteine-type endopeptidase inhibitor activity involved in apoptotic process ISO
Inferred from Sequence Orthology
more info
  
enables molecular sequestering activity ISO
Inferred from Sequence Orthology
more info
  
enables small molecule binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in apoptotic process IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within defense response to Gram-positive bacterium ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of apoptotic process ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
tumor necrosis factor alpha-induced protein 8
Names
tumor necrosis factor, alpha-induced protein 8

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001107387.2 → NP_001100857.2  tumor necrosis factor alpha-induced protein 8

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000018
    UniProtKB/TrEMBL
    A6IX01, D4A9G3
    Related
    ENSRNOP00000021972.4, ENSRNOT00000021972.7
    Conserved Domains (1) summary
    pfam05527
    Location:51 → 205
    DUF758; Domain of unknown function (DUF758)

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086036.1 Reference GRCr8

    Range
    45370334..45486036
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006254709.5 → XP_006254771.1  tumor necrosis factor alpha-induced protein 8 isoform X3

    UniProtKB/TrEMBL
    A0A8I5Y0F2
    Related
    ENSRNOP00000076830.1, ENSRNOT00000118975.2
    Conserved Domains (1) summary
    pfam05527
    Location:27 → 181
    DUF758; Domain of unknown function (DUF758)

  2. XM_039096838.2 → XP_038952766.1  tumor necrosis factor alpha-induced protein 8 isoform X1

    UniProtKB/TrEMBL
    A0A0G2K2P3
    Related
    ENSRNOP00000072322.2, ENSRNOT00000086431.3
    Conserved Domains (1) summary
    pfam05527
    Location:37 → 191
    DUF758; Domain of unknown function (DUF758)

  3. XM_006254708.5 → XP_006254770.1  tumor necrosis factor alpha-induced protein 8 isoform X2

    UniProtKB/TrEMBL
    A0A8I6AJX1
    Related
    ENSRNOP00000108196.1, ENSRNOT00000140138.1
    Conserved Domains (1) summary
    pfam05527
    Location:31 → 185
    DUF758; Domain of unknown function (DUF758)

  4. XM_063277358.1 → XP_063133428.1  tumor necrosis factor alpha-induced protein 8 isoform X4

    UniProtKB/TrEMBL
    A6IX03
Nucleotide Protein Strain
Heading Accession and Version

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