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Wdr33 WD repeat domain 33 [ Rattus norvegicus (Norway rat) ]

Gene ID: 307524, updated on 2-Nov-2024

Summary

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Official Symbol
Wdr33provided by RGD
Official Full Name
WD repeat domain 33provided by RGD
Primary source
RGD:1309230
See related
EnsemblRapid:ENSRNOG00000011382 AllianceGenome:RGD:1309230
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to be involved in mRNA 3'-end processing. Predicted to be located in fibrillar center and nucleoplasm. Predicted to be part of mRNA cleavage and polyadenylation specificity factor complex. Orthologous to human WDR33 (WD repeat domain 33). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Thymus (RPKM 162.1), Kidney (RPKM 151.2) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Wdr33 in Genome Data Viewer
Location:
18p12
Exon count:
25
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 18 NC_086036.1 (23706708..23812985)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 18 NC_051353.1 (23432233..23535460)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 18 NC_005117.4 (24584832..24689681)

Chromosome 18 - NC_086036.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC100910201 Neighboring gene AMMECR1 like Neighboring gene small nucleolar RNA SNORA21 Neighboring gene RNA polymerase II subunit D Neighboring gene SFT2 domain containing 3 Neighboring gene LIM zinc finger domain containing 2 Neighboring gene G protein-coupled receptor 17 Neighboring gene myosin VIIb Neighboring gene POTE ankyrin domain family, member F

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. A novel WD40 repeat protein, WDC146, highly expressed during spermatogenesis in a stage-specific manner. Ito S, et al. Biochem Biophys Res Commun, 2001 Jan 26. PMID 11162572
  2. Pre-mRNA 3'-end processing complex assembly and function. Chan S, et al. Wiley Interdiscip Rev RNA, 2011 May-Jun. PMID 21957020, Free PMC Article
  3. Means to an end: mechanisms of alternative polyadenylation of messenger RNA precursors. Gruber AR, et al. Wiley Interdiscip Rev RNA, 2014 Mar-Apr. PMID 24243805, Free PMC Article
  4. The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts. Baltz AG, et al. Mol Cell, 2012 Jun 8. PMID 22681889
  5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
  
involved_in mRNA 3'-end processing IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in fibrillar center ISO
Inferred from Sequence Orthology
more info
  
part_of mRNA cleavage and polyadenylation specificity factor complex IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
pre-mRNA 3' end processing protein WDR33
Names
WD repeat-containing protein 33

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001107398.2 → NP_001100868.2  pre-mRNA 3' end processing protein WDR33

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000018
    UniProtKB/TrEMBL
    F1LT09
    Related
    ENSRNOP00000112834.1, ENSRNOT00000133811.1
    Conserved Domains (5) summary
    pfam01391
    Location:717 → 769
    Collagen; Collagen triple helix repeat (20 copies)
    COG2319
    Location:121 → 405
    WD40; WD40 repeat [General function prediction only]
    cd00200
    Location:121 → 402
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    pfam09606
    Location:565 → 972
    Med15; ARC105 or Med15 subunit of Mediator complex non-fungal
    sd00039
    Location:122 → 159
    7WD40; WD40 repeat [structural motif]

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086036.1 Reference GRCr8

    Range
    23706708..23812985
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063277379.1 → XP_063133449.1  pre-mRNA 3' end processing protein WDR33 isoform X1

    Related
    ENSRNOP00000110865.1, ENSRNOT00000173447.1

  2. XM_063277380.1 → XP_063133450.1  pre-mRNA 3' end processing protein WDR33 isoform X2

  3. XM_063277381.1 → XP_063133451.1  pre-mRNA 3' end processing protein WDR33 isoform X3

  4. XM_063277382.1 → XP_063133452.1  pre-mRNA 3' end processing protein WDR33 isoform X4

  5. XM_063277384.1 → XP_063133454.1  pre-mRNA 3' end processing protein WDR33 isoform X6

  6. XM_063277383.1 → XP_063133453.1  pre-mRNA 3' end processing protein WDR33 isoform X5

  7. XM_063277385.1 → XP_063133455.1  pre-mRNA 3' end processing protein WDR33 isoform X7

    Related
    ENSRNOP00000100588.1, ENSRNOT00000141009.1
Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

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