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Celf4 CUGBP, Elav-like family member 4 [ Rattus norvegicus (Norway rat) ]

Gene ID: 307540, updated on 2-Nov-2024

Summary

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Official Symbol
Celf4provided by RGD
Official Full Name
CUGBP, Elav-like family member 4provided by RGD
Primary source
RGD:1307630
See related
EnsemblRapid:ENSRNOG00000014503 AllianceGenome:RGD:1307630
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Brunol4
Summary
Predicted to enable mRNA binding activity and pre-mRNA binding activity. Predicted to be involved in positive regulation of mRNA splicing, via spliceosome. Predicted to act upstream of or within several processes, including mRNA splicing, via spliceosome; negative regulation of excitatory postsynaptic potential; and regulation of mRNA splicing, via spliceosome. Predicted to be located in cytoplasm and nucleoplasm. Orthologous to human CELF4 (CUGBP Elav-like family member 4). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Restricted expression toward (RPKM 286.4) See more
Orthologs
human mouse all
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Genomic context

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See Celf4 in Genome Data Viewer
Location:
18p12
Exon count:
17
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 18 NC_086036.1 (17061284..17339747, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 18 NC_051353.1 (16786578..17065045, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 18 NC_005117.4 (17689090..18079835, complement)

Chromosome 18 - NC_086036.1Genomic Context describing neighboring genes Neighboring gene formin homology 2 domain containing 3 Neighboring gene glyceraldehyde-3-phosphate dehydrogenase-like Neighboring gene tubulin polyglutamylase complex subunit 2 Neighboring gene KIAA1328 homolog Neighboring gene uncharacterized LOC120098197 Neighboring gene uncharacterized LOC103694180

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Etiology of a genetically complex seizure disorder in Celf4 mutant mice. Wagnon JL, et al. Genes Brain Behav, 2011 Oct. PMID 21745337, Free PMC Article
  2. MBNL and CELF proteins regulate alternative splicing of the skeletal muscle chloride channel CLCN1. Kino Y, et al. Nucleic Acids Res, 2009 Oct. PMID 19720736, Free PMC Article
  3. The expression analysis of Sfrs10 and Celf4 during mouse retinal development. Karunakaran DK, et al. Gene Expr Patterns, 2013 Dec. PMID 23932931, Free PMC Article
  4. The CELF family of RNA binding proteins is implicated in cell-specific and developmentally regulated alternative splicing. Ladd AN, et al. Mol Cell Biol, 2001 Feb. PMID 11158314, Free PMC Article
  5. Tau exon 10, whose missplicing causes frontotemporal dementia, is regulated by an intricate interplay of cis elements and trans factors. Wang J, et al. J Neurochem, 2004 Mar. PMID 15009664

See all (8) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables mRNA binding ISO
Inferred from Sequence Orthology
more info
  
enables pre-mRNA binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within alternative mRNA splicing, via spliceosome ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of excitatory postsynaptic potential ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within in utero embryonic development ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within mRNA splice site recognition ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within negative regulation of excitatory postsynaptic potential ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within negative regulation of mRNA splicing, via spliceosome ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of mRNA splicing, via spliceosome ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within regulation of alternative mRNA splicing, via spliceosome ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of alternative mRNA splicing, via spliceosome ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within regulation of retina development in camera-type eye ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  
located_in postsynapse IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
CUGBP Elav-like family member 4
Names
CUG-BP- and ETR-3-like factor 4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001401250.2 → NP_001388179.1  CUGBP Elav-like family member 4

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000018
    UniProtKB/TrEMBL
    A0A8I5ZKE7
    Related
    ENSRNOP00000077924.1, ENSRNOT00000107952.2

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086036.1 Reference GRCr8

    Range
    17061284..17339747 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039096895.2 → XP_038952823.1  CUGBP Elav-like family member 4 isoform X15

    Conserved Domains (3) summary
    cd12632
    Location:49 → 135
    RRM1_CELF3_4_5_6; RNA recognition motif 1 (RRM1) found in CUGBP Elav-like family member CELF-3, CELF-4, CELF-5, CELF-6 and similar proteins
    cd12635
    Location:141 → 221
    RRM2_CELF3_4_5_6; RNA recognition motif 2 (RRM2) found in CUGBP Elav-like family member CELF-3, CELF-4, CELF-5, CELF-6 and similar proteins
    cl17169
    Location:407 → 435
    RRM_SF; RNA recognition motif (RRM) superfamily

  2. XM_039096893.2 → XP_038952821.1  CUGBP Elav-like family member 4 isoform X13

    Conserved Domains (3) summary
    cd12632
    Location:49 → 135
    RRM1_CELF3_4_5_6; RNA recognition motif 1 (RRM1) found in CUGBP Elav-like family member CELF-3, CELF-4, CELF-5, CELF-6 and similar proteins
    cd12635
    Location:150 → 230
    RRM2_CELF3_4_5_6; RNA recognition motif 2 (RRM2) found in CUGBP Elav-like family member CELF-3, CELF-4, CELF-5, CELF-6 and similar proteins
    cl17169
    Location:416 → 444
    RRM_SF; RNA recognition motif (RRM) superfamily

  3. XM_063277417.1 → XP_063133487.1  CUGBP Elav-like family member 4 isoform X37

  4. XM_039096896.2 → XP_038952824.1  CUGBP Elav-like family member 4 isoform X14

    Conserved Domains (3) summary
    cd12632
    Location:49 → 135
    RRM1_CELF3_4_5_6; RNA recognition motif 1 (RRM1) found in CUGBP Elav-like family member CELF-3, CELF-4, CELF-5, CELF-6 and similar proteins
    cd12635
    Location:140 → 220
    RRM2_CELF3_4_5_6; RNA recognition motif 2 (RRM2) found in CUGBP Elav-like family member CELF-3, CELF-4, CELF-5, CELF-6 and similar proteins
    cl17169
    Location:406 → 434
    RRM_SF; RNA recognition motif (RRM) superfamily

  5. XM_039096913.2 → XP_038952841.1  CUGBP Elav-like family member 4 isoform X9

    Conserved Domains (3) summary
    cd12632
    Location:49 → 135
    RRM1_CELF3_4_5_6; RNA recognition motif 1 (RRM1) found in CUGBP Elav-like family member CELF-3, CELF-4, CELF-5, CELF-6 and similar proteins
    cd12635
    Location:140 → 220
    RRM2_CELF3_4_5_6; RNA recognition motif 2 (RRM2) found in CUGBP Elav-like family member CELF-3, CELF-4, CELF-5, CELF-6 and similar proteins
    cl17169
    Location:406 → 454
    RRM_SF; RNA recognition motif (RRM) superfamily

  6. XM_039096889.2 → XP_038952817.1  CUGBP Elav-like family member 4 isoform X4

    Conserved Domains (3) summary
    cd12632
    Location:49 → 135
    RRM1_CELF3_4_5_6; RNA recognition motif 1 (RRM1) found in CUGBP Elav-like family member CELF-3, CELF-4, CELF-5, CELF-6 and similar proteins
    cd12635
    Location:150 → 230
    RRM2_CELF3_4_5_6; RNA recognition motif 2 (RRM2) found in CUGBP Elav-like family member CELF-3, CELF-4, CELF-5, CELF-6 and similar proteins
    cl17169
    Location:416 → 464
    RRM_SF; RNA recognition motif (RRM) superfamily

  7. XM_039096892.2 → XP_038952820.1  CUGBP Elav-like family member 4 isoform X11

    Conserved Domains (4) summary
    TIGR01628
    Location:56 → 378
    PABP-1234; polyadenylate binding protein, human types 1, 2, 3, 4 family
    cd12632
    Location:49 → 135
    RRM1_CELF3_4_5_6; RNA recognition motif 1 (RRM1) found in CUGBP Elav-like family member CELF-3, CELF-4, CELF-5, CELF-6 and similar proteins
    cd12635
    Location:151 → 231
    RRM2_CELF3_4_5_6; RNA recognition motif 2 (RRM2) found in CUGBP Elav-like family member CELF-3, CELF-4, CELF-5, CELF-6 and similar proteins
    cl17169
    Location:417 → 445
    RRM_SF; RNA recognition motif (RRM) superfamily

  8. XM_039096888.2 → XP_038952816.1  CUGBP Elav-like family member 4 isoform X3

    Conserved Domains (4) summary
    TIGR01628
    Location:56 → 378
    PABP-1234; polyadenylate binding protein, human types 1, 2, 3, 4 family
    cd12632
    Location:49 → 135
    RRM1_CELF3_4_5_6; RNA recognition motif 1 (RRM1) found in CUGBP Elav-like family member CELF-3, CELF-4, CELF-5, CELF-6 and similar proteins
    cd12635
    Location:151 → 231
    RRM2_CELF3_4_5_6; RNA recognition motif 2 (RRM2) found in CUGBP Elav-like family member CELF-3, CELF-4, CELF-5, CELF-6 and similar proteins
    cl17169
    Location:417 → 465
    RRM_SF; RNA recognition motif (RRM) superfamily

  9. XM_063277416.1 → XP_063133486.1  CUGBP Elav-like family member 4 isoform X36

  10. XM_063277391.1 → XP_063133461.1  CUGBP Elav-like family member 4 isoform X6

  11. XM_063277392.1 → XP_063133462.1  CUGBP Elav-like family member 4 isoform X10

  12. XM_063277393.1 → XP_063133463.1  CUGBP Elav-like family member 4 isoform X16

  13. XM_039096886.2 → XP_038952814.1  CUGBP Elav-like family member 4 isoform X1

    Conserved Domains (4) summary
    TIGR01628
    Location:56 → 378
    PABP-1234; polyadenylate binding protein, human types 1, 2, 3, 4 family
    cd12632
    Location:49 → 135
    RRM1_CELF3_4_5_6; RNA recognition motif 1 (RRM1) found in CUGBP Elav-like family member CELF-3, CELF-4, CELF-5, CELF-6 and similar proteins
    cd12635
    Location:151 → 231
    RRM2_CELF3_4_5_6; RNA recognition motif 2 (RRM2) found in CUGBP Elav-like family member CELF-3, CELF-4, CELF-5, CELF-6 and similar proteins
    cl17169
    Location:417 → 465
    RRM_SF; RNA recognition motif (RRM) superfamily

  14. XM_063277390.1 → XP_063133460.1  CUGBP Elav-like family member 4 isoform X5

  15. XM_063277389.1 → XP_063133459.1  CUGBP Elav-like family member 4 isoform X2

  16. XM_039096890.2 → XP_038952818.1  CUGBP Elav-like family member 4 isoform X7

    Conserved Domains (4) summary
    TIGR01628
    Location:56 → 378
    PABP-1234; polyadenylate binding protein, human types 1, 2, 3, 4 family
    cd12632
    Location:49 → 135
    RRM1_CELF3_4_5_6; RNA recognition motif 1 (RRM1) found in CUGBP Elav-like family member CELF-3, CELF-4, CELF-5, CELF-6 and similar proteins
    cd12635
    Location:151 → 231
    RRM2_CELF3_4_5_6; RNA recognition motif 2 (RRM2) found in CUGBP Elav-like family member CELF-3, CELF-4, CELF-5, CELF-6 and similar proteins
    cl17169
    Location:417 → 445
    RRM_SF; RNA recognition motif (RRM) superfamily

  17. XM_039096894.2 → XP_038952822.1  CUGBP Elav-like family member 4 isoform X12

    Conserved Domains (3) summary
    cd12632
    Location:49 → 135
    RRM1_CELF3_4_5_6; RNA recognition motif 1 (RRM1) found in CUGBP Elav-like family member CELF-3, CELF-4, CELF-5, CELF-6 and similar proteins
    cd12635
    Location:140 → 220
    RRM2_CELF3_4_5_6; RNA recognition motif 2 (RRM2) found in CUGBP Elav-like family member CELF-3, CELF-4, CELF-5, CELF-6 and similar proteins
    cl17169
    Location:406 → 434
    RRM_SF; RNA recognition motif (RRM) superfamily

  18. XM_039096891.2 → XP_038952819.1  CUGBP Elav-like family member 4 isoform X8

    Conserved Domains (3) summary
    cd12632
    Location:49 → 135
    RRM1_CELF3_4_5_6; RNA recognition motif 1 (RRM1) found in CUGBP Elav-like family member CELF-3, CELF-4, CELF-5, CELF-6 and similar proteins
    cd12635
    Location:150 → 230
    RRM2_CELF3_4_5_6; RNA recognition motif 2 (RRM2) found in CUGBP Elav-like family member CELF-3, CELF-4, CELF-5, CELF-6 and similar proteins
    cl17169
    Location:416 → 444
    RRM_SF; RNA recognition motif (RRM) superfamily

  19. XM_063277413.1 → XP_063133483.1  CUGBP Elav-like family member 4 isoform X33

  20. XM_063277414.1 → XP_063133484.1  CUGBP Elav-like family member 4 isoform X34

  21. XM_063277412.1 → XP_063133482.1  CUGBP Elav-like family member 4 isoform X33

  22. XM_063277405.1 → XP_063133475.1  CUGBP Elav-like family member 4 isoform X27

  23. XM_063277411.1 → XP_063133481.1  CUGBP Elav-like family member 4 isoform X32

  24. XM_063277404.1 → XP_063133474.1  CUGBP Elav-like family member 4 isoform X26

  25. XM_063277399.1 → XP_063133469.1  CUGBP Elav-like family member 4 isoform X22

  26. XM_063277410.1 → XP_063133480.1  CUGBP Elav-like family member 4 isoform X31

  27. XM_063277403.1 → XP_063133473.1  CUGBP Elav-like family member 4 isoform X25

  28. XM_063277398.1 → XP_063133468.1  CUGBP Elav-like family member 4 isoform X21

  29. XM_063277409.1 → XP_063133479.1  CUGBP Elav-like family member 4 isoform X30

  30. XM_063277402.1 → XP_063133472.1  CUGBP Elav-like family member 4 isoform X24

  31. XM_063277397.1 → XP_063133467.1  CUGBP Elav-like family member 4 isoform X20

  32. XM_063277395.1 → XP_063133465.1  CUGBP Elav-like family member 4 isoform X18

  33. XM_063277415.1 → XP_063133485.1  CUGBP Elav-like family member 4 isoform X35

  34. XM_063277408.1 → XP_063133478.1  CUGBP Elav-like family member 4 isoform X29

  35. XM_063277406.1 → XP_063133476.1  CUGBP Elav-like family member 4 isoform X28

  36. XM_063277400.1 → XP_063133470.1  CUGBP Elav-like family member 4 isoform X23

    UniProtKB/TrEMBL
    A0A8I5ZKE7

  37. XM_063277396.1 → XP_063133466.1  CUGBP Elav-like family member 4 isoform X19

  38. XM_063277394.1 → XP_063133464.1  CUGBP Elav-like family member 4 isoform X17

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001107400.1: Suppressed sequence

    Description
    NM_001107400.1: This RefSeq was removed because currently there is not sufficient data to support this transcript.
Nucleotide Protein Strain
Heading Accession and Version

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