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Asxl3 ASXL transcriptional regulator 3 [ Rattus norvegicus (Norway rat) ]

Gene ID: 307555, updated on 2-Nov-2024

Summary

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Official Symbol
Asxl3provided by RGD
Official Full Name
ASXL transcriptional regulator 3provided by RGD
Primary source
RGD:1305869
See related
EnsemblRapid:ENSRNOG00000015383 AllianceGenome:RGD:1305869
Gene type
protein coding
RefSeq status
MODEL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
RGD1305869
Summary
Predicted to enable DNA binding activity and metal ion binding activity. Predicted to be involved in negative regulation of lipid biosynthetic process. Human ortholog(s) of this gene implicated in Bainbridge-Ropers syndrome. Orthologous to human ASXL3 (ASXL transcriptional regulator 3). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Brain (RPKM 15.6), Spleen (RPKM 3.6) and 7 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Asxl3 in Genome Data Viewer
Location:
18p12
Exon count:
13
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 18 NC_086036.1 (13868223..14040867)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 18 NC_051353.1 (13593529..13766324)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 18 NC_005117.4 (13322148..13496230)

Chromosome 18 - NC_086036.1Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 4930426D05 gene like Neighboring gene kelch-like family member 14 Neighboring gene uncharacterized LOC134482977 Neighboring gene coiled-coil domain containing 178 Neighboring gene small ribosomal subunit protein eS27-like Neighboring gene U2 spliceosomal RNA Neighboring gene nucleolar protein 4

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Repression of LXRα by a novel member of additional sex comb-like family, ASXL3. Shin N, et al. Biochem Biophys Res Commun, 2014 Nov 28. PMID 25450400
  2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in negative regulation of lipid biosynthetic process ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
putative Polycomb group protein ASXL3
Names
additional sex combs like 3, transcriptional regulator
additional sex combs like transcriptional regulator 3

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086036.1 Reference GRCr8

    Range
    13868223..14040867
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063277685.1 → XP_063133755.1  putative Polycomb group protein ASXL3

  2. XM_056984980.2 → XP_056840960.1  putative Polycomb group protein ASXL3

    Related
    ENSRNOP00000100421.1, ENSRNOT00000139840.1
Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

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