Ces5a carboxylesterase 5A [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Ces5aprovided by RGD
Official Full Name: carboxylesterase 5Aprovided by RGD
Primary source: RGD:1549717
See related: EnsemblRapid:ENSRNOG00000025710 AllianceGenome:RGD:1549717
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Ces5; Ces7
Summary: Predicted to enable methyl indole-3-acetate esterase activity. Predicted to be located in extracellular region. Predicted to be integral component of membrane. Orthologous to human CES5A (carboxylesterase 5A). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Testes (RPKM 15.6) and Brain (RPKM 3.5) See more
Orthologs: human mouse all
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Genomic context

Location:: 19p12

Exon count:: 20

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	19	NC_086037.1 (11198829..11504887)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	19	NC_051354.1 (11469431..11499007)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	19	NC_005118.4 (12097529..12136579)

Chromosome 19 - NC_086037.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

CES5A plays an important role in sperm maturation and male fertility in the rat.
Title: An epididymis-specific carboxyl esterase CES5A is required for sperm capacitation and male fertility in the rat.

Submit: New GeneRIF Correction

General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables carboxylesterase activity	IEA Inferred from Electronic Annotation more info
enables carboxylic ester hydrolase activity	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in extracellular region	IEA Inferred from Electronic Annotation more info
located_in membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: carboxylesterase 5A

Names: carboxylesterase 615; carboxylesterase 7; carboxylesterase-like urinary excreted protein homolog; cauxin; epididymis-specific gene 615 protein

NP_001012056.2

EC 3.1.1.1

XP_063134066.1

EC 3.1.1.1

XP_063134067.1

EC 3.1.1.1

XP_063134068.1

EC 3.1.1.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001012056.2 → NP_001012056.2 carboxylesterase 5A precursor

Status: VALIDATED

Source sequence(s)

JAXUCZ010000019

UniProtKB/Swiss-Prot

Q5GRG2

UniProtKB/TrEMBL

F1M786

Related

ENSRNOP00000045129.5, ENSRNOT00000049452.6

Conserved Domains (1) summary

cd00312
Location:40 → 529

Esterase_lipase; Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These ...