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Gpt2 glutamic--pyruvic transaminase 2 [ Rattus norvegicus (Norway rat) ]

Gene ID: 307759, updated on 2-Nov-2024

Summary

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Official Symbol
Gpt2provided by RGD
Official Full Name
glutamic--pyruvic transaminase 2provided by RGD
Primary source
RGD:1305462
See related
EnsemblRapid:ENSRNOG00000059579 AllianceGenome:RGD:1305462
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
ALT2; Cc2-5
Summary
Predicted to enable L-alanine:2-oxoglutarate aminotransferase activity. Involved in several processes, including cellular response to insulin stimulus; gluconeogenesis; and response to testosterone. Located in extracellular space. Biomarker of type 2 diabetes mellitus. Human ortholog(s) of this gene implicated in neurodevelopmental disorder with spastic paraplegia and microcephaly. Orthologous to human GPT2 (glutamic--pyruvic transaminase 2). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Adrenal (RPKM 312.5), Liver (RPKM 220.8) and 8 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Gpt2 in Genome Data Viewer
Location:
19p11
Exon count:
13
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 19 NC_086037.1 (37700023..37734551, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 19 NC_051354.1 (21526800..21561314, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 19 NC_005118.4 (22599003..22633529, complement)

Chromosome 19 - NC_086037.1Genomic Context describing neighboring genes Neighboring gene neuropilin and tolloid like 2 Neighboring gene DnaJ heat shock protein family (Hsp40) member A2 Neighboring gene uncharacterized LOC102548349 Neighboring gene uncharacterized LOC120098665 Neighboring gene similar to human chromosome 16 open reading frame 87

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Alanine aminotransferase regulation by androgens in non-hepatic tissues. Coss CC, et al. Pharm Res, 2012 Apr. PMID 22167351
  2. Isoform-specific alanine aminotransferase measurement can distinguish hepatic from extrahepatic injury in humans. Rafter I, et al. Int J Mol Med, 2012 Nov. PMID 22922605
  3. Alanine aminotransferase isoenzymes: molecular cloning and quantitative analysis of tissue expression in rats and serum elevation in liver toxicity. Yang RZ, et al. Hepatology, 2009 Feb. PMID 19085960, Free PMC Article
  4. Increased hepatic expression is a major determinant of serum alanine aminotransferase elevation in mice with nonalcoholic steatohepatitis. Liu R, et al. Liver Int, 2009 Mar. PMID 18710424
  5. Hepatic ALT isoenzymes are elevated in gluconeogenic conditions including diabetes and suppressed by insulin at the protein level. Qian K, et al. Diabetes Metab Res Rev, 2015 Sep. PMID 25865565, Free PMC Article

See all (11) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables L-alanine:2-oxoglutarate aminotransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables L-alanine:2-oxoglutarate aminotransferase activity ISO
Inferred from Sequence Orthology
more info
  
enables pyridoxal phosphate binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in 2-oxoglutarate metabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in L-alanine catabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in L-alanine metabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in cellular response to insulin stimulus IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in gluconeogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in response to starvation IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in response to testosterone IEP
Inferred from Expression Pattern
more info
 PubMed 
Component Evidence Code Pubs
located_in extracellular space IDA
Inferred from Direct Assay
more info
 PubMed 
located_in mitochondrion ISO
Inferred from Sequence Orthology
more info
 PubMed 

General protein information

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Preferred Names
alanine aminotransferase 2
Names
glutamic pyruvate transaminase (alanine aminotransferase) 2
NP_001012057.1
XP_008770627.1
XP_008770628.1
XP_063134088.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001012057.2 → NP_001012057.1  alanine aminotransferase 2

    See identical proteins and their annotated locations for NP_001012057.1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000019
    UniProtKB/TrEMBL
    A0A8I6ACI1, A0A8I6ARL0, A6KDD7
    Related
    ENSRNOP00000090767.1, ENSRNOT00000099582.2
    Conserved Domains (2) summary
    cd00609
    Location:123 → 512
    AAT_like; Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine ...
    PTZ00377
    Location:48 → 522
    PTZ00377; alanine aminotransferase; Provisional

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086037.1 Reference GRCr8

    Range
    37700023..37734551 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_008772406.4 → XP_008770628.1  alanine aminotransferase 2 isoform X1

    See identical proteins and their annotated locations for XP_008770628.1

    UniProtKB/TrEMBL
    A0A8I6ACI1, A0A8I6ARL0, A6KDD7
    Conserved Domains (2) summary
    cd00609
    Location:123 → 512
    AAT_like; Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine ...
    PTZ00377
    Location:48 → 522
    PTZ00377; alanine aminotransferase; Provisional

  2. XM_063278018.1 → XP_063134088.1  alanine aminotransferase 2 isoform X1

    UniProtKB/TrEMBL
    A0A8I6ARL0, A6KDD7
    Related
    ENSRNOP00000069387.2, ENSRNOT00000077275.3

  3. XM_008772405.4 → XP_008770627.1  alanine aminotransferase 2 isoform X1

    See identical proteins and their annotated locations for XP_008770627.1

    UniProtKB/TrEMBL
    A0A8I6ACI1, A0A8I6ARL0, A6KDD7
    Conserved Domains (2) summary
    cd00609
    Location:123 → 512
    AAT_like; Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine ...
    PTZ00377
    Location:48 → 522
    PTZ00377; alanine aminotransferase; Provisional
Nucleotide Protein Strain
Heading Accession and Version

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