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Nhlrc2 NHL repeat containing 2 [ Rattus norvegicus (Norway rat) ]

Gene ID: 307986, updated on 2-Nov-2024

Summary

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Official Symbol
Nhlrc2provided by RGD
Official Full Name
NHL repeat containing 2provided by RGD
Primary source
RGD:1307348
See related
EnsemblRapid:ENSRNOG00000016948 AllianceGenome:RGD:1307348
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to be located in cytosol. Orthologous to human NHLRC2 (NHL repeat containing 2). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Kidney (RPKM 157.8), Lung (RPKM 138.7) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Nhlrc2 in Genome Data Viewer
Location:
1q55
Exon count:
14
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (265594915..265655647)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (255589743..255648904)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (277355619..277415940)

Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene small nucleolar RNA SNORA17 Neighboring gene ribosomal protein L19, pseudogene 2 Neighboring gene DNA cross-link repair 1A Neighboring gene uncharacterized LOC102547573 Neighboring gene uncharacterized LOC120100064 Neighboring gene adrenoceptor beta 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Component Evidence Code Pubs
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
NHL repeat-containing protein 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001107444.2 → NP_001100914.1  NHL repeat-containing protein 2

    See identical proteins and their annotated locations for NP_001100914.1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000001
    UniProtKB/TrEMBL
    A0A8I6APX7, A6JI26, D3ZLM5
    Related
    ENSRNOP00000022788.4, ENSRNOT00000022788.7
    Conserved Domains (4) summary
    cd03012
    Location:55 → 182
    TlpA_like_DipZ_like; TlpA-like family, DipZ-like subfamily; composed uncharacterized proteins containing a TlpA-like TRX domain. Some members show domain architectures similar to that of E. coli DipZ protein (also known as DsbD). The only eukaryotic members of the TlpA ...
    cd05819
    Location:163 → 208
    NHL; NHL repeat [structural motif]
    cd14951
    Location:261 → 623
    NHL-2_like; NHL repeat domain of NHL repeat-containing protein 2 and similar proteins
    cl18310
    Location:163 → 296
    NHL; NHL repeat unit of beta-propeller proteins

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086019.1 Reference GRCr8

    Range
    265594915..265655647
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039110139.2 → XP_038966067.1  NHL repeat-containing protein 2 isoform X1

    Conserved Domains (1) summary
    PLN02919
    Location:30 → 478
    PLN02919; haloacid dehalogenase-like hydrolase family protein

RNA

  1. XR_010066447.1 RNA Sequence

  2. XR_010066446.1 RNA Sequence

  3. XR_010066448.1 RNA Sequence

  4. XR_010066449.1 RNA Sequence

  5. XR_351167.4 RNA Sequence

  6. XR_351166.4 RNA Sequence

  7. XR_005504465.2 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version

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