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Zbtb2 zinc finger and BTB domain containing 2 [ Rattus norvegicus (Norway rat) ]

Gene ID: 308126, updated on 2-Nov-2024

Summary

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Official Symbol
Zbtb2provided by RGD
Official Full Name
zinc finger and BTB domain containing 2provided by RGD
Primary source
RGD:1306621
See related
AllianceGenome:RGD:1306621
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable DNA-binding transcription repressor activity, RNA polymerase II-specific; RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; and identical protein binding activity. Predicted to be involved in negative regulation of transcription by RNA polymerase II; regulation of cytokine production; and regulation of immune system process. Predicted to be active in nucleoplasm. Orthologous to human ZBTB2 (zinc finger and BTB domain containing 2). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Thymus (RPKM 84.6), Lung (RPKM 48.1) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Zbtb2 in Genome Data Viewer
Location:
1q11
Exon count:
4
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (43232839..43252115, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (40827457..40846733, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (40914175..40933586, complement)

Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134484990 Neighboring gene A-kinase anchoring protein 12 Neighboring gene zinc finger and BTB domain containing 2 like Neighboring gene required for meiotic nuclear division 1 homolog Neighboring gene acidic residue methyltransferase 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. ZBTB2, a novel master regulator of the p53 pathway. Jeon BN, et al. J Biol Chem, 2009 Jul 3. PMID 19380588, Free PMC Article
  2. ZBTB2 increases PDK4 expression by transcriptional repression of RelA/p65. Kim MY, et al. Nucleic Acids Res, 2015 Feb 18. PMID 25609694, Free PMC Article
  3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables DNA-binding transcription repressor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
  
enables DNA-binding transcription repressor activity, RNA polymerase II-specific ISO
Inferred from Sequence Orthology
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding ISO
Inferred from Sequence Orthology
more info
  
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
  
enables sequence-specific double-stranded DNA binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in negative regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in negative regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of cytokine production IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of immune system process IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in nucleoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
zinc finger and BTB domain-containing protein 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001107460.1 → NP_001100930.1  zinc finger and BTB domain-containing protein 2

    See identical proteins and their annotated locations for NP_001100930.1

    Status: PROVISIONAL

    Source sequence(s)
    CH474052
    UniProtKB/TrEMBL
    A6KIL1, D4ABS0
    Conserved Domains (4) summary
    sd00017
    Location:365 → 385
    ZF_C2H2; C2H2 Zn finger [structural motif]
    cd18193
    Location:3 → 117
    BTB_POZ_ZBTB2; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 2 (ZBTB2)
    pfam00096
    Location:363 → 385
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:377 → 399
    zf-H2C2_2; Zinc-finger double domain

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086019.1 Reference GRCr8

    Range
    43232839..43252115 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039110625.2 → XP_038966553.1  zinc finger and BTB domain-containing protein 2 isoform X1

    UniProtKB/TrEMBL
    A6KIL1, D4ABS0
    Conserved Domains (4) summary
    sd00017
    Location:365 → 385
    ZF_C2H2; C2H2 Zn finger [structural motif]
    cd18193
    Location:3 → 117
    BTB_POZ_ZBTB2; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 2 (ZBTB2)
    pfam00096
    Location:363 → 385
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:377 → 399
    zf-H2C2_2; Zinc-finger double domain

  2. XM_039110632.2 → XP_038966560.1  zinc finger and BTB domain-containing protein 2 isoform X1

    UniProtKB/TrEMBL
    A6KIL1, D4ABS0
    Conserved Domains (4) summary
    sd00017
    Location:365 → 385
    ZF_C2H2; C2H2 Zn finger [structural motif]
    cd18193
    Location:3 → 117
    BTB_POZ_ZBTB2; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 2 (ZBTB2)
    pfam00096
    Location:363 → 385
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:377 → 399
    zf-H2C2_2; Zinc-finger double domain
Nucleotide Protein Strain
Heading Accession and Version

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