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Zfp667 zinc finger protein 667 [ Rattus norvegicus (Norway rat) ]

Gene ID: 308326, updated on 2-Nov-2024

Summary

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Official Symbol
Zfp667provided by RGD
Official Full Name
zinc finger protein 667provided by RGD
Primary source
RGD:1359114
See related
EnsemblRapid:ENSRNOG00000033906 AllianceGenome:RGD:1359114
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Mip1; Znf667
Summary
Predicted to enable DNA-binding transcription factor activity and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be located in nucleus. Orthologous to human ZNF667 (zinc finger protein 667). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Brain (RPKM 46.1), Muscle (RPKM 39.7) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Zfp667 in Genome Data Viewer
Location:
1q12
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (76634897..76655133, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (67601803..67622041, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (71270101..71290337, complement)

Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134482884 Neighboring gene zinc finger protein 829 like, pseudogene 1 Neighboring gene zinc finger protein 583 Neighboring gene uncharacterized LOC134482883 Neighboring gene zinc finger and SCAN domain containing 5B

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Oxidative stress-mediated up-regulation of myocardial ischemic preconditioning up-regulated protein 1 gene expression in H9c2 cardiomyocytes is regulated by cyclic AMP-response element binding protein. Qu S, et al. Free Radic Biol Med, 2010 Aug 15. PMID 20488243
  2. Tissue expression and subcellular localization of Mipu1, a novel myocardial ischemia-related gene. Wang G, et al. Braz J Med Biol Res, 2010 Jan. PMID 19649394
  3. Identification and characterization of the minimal promoter of Mipu1: the role of GC boxes in the regulation of basal transcription. Lv B, et al. Acta Biochim Biophys Sin (Shanghai), 2009 Apr. PMID 19352546
  4. Mipu1, a novel rat zinc-finger protein, inhibits transcriptional activities of AP-1 and SRE in mitogen-activated protein kinase signaling pathway. Wang G, et al. Mol Cell Biochem, 2009 Feb. PMID 19015817
  5. ZNF667/Mipu1 is a novel anti-apoptotic factor that directly regulates the expression of the rat Bax gene in H9c2 cells. Jiang L, et al. PLoS One, 2014. PMID 25397408, Free PMC Article

See all (9) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. ZNF667 that confers cytoprotection is a novel regulator of the rat Bax gene.
    Title: ZNF667/Mipu1 is a novel anti-apoptotic factor that directly regulates the expression of the rat Bax gene in H9c2 cells.
  2. Mip1 over-expression inhibited H2O2-induced apoptosis and upregulation of Fas induced by H2O2 in H9c2 myogenic cells.
    Title: Mipu1 protects H9c2 myogenic cells from hydrogen peroxide-induced apoptosis through inhibition of the expression of the death receptor Fas.
  3. Mipu1 is involved in HIF-1-mediate cytoprotection by inhibiting the expression of Bax and interfering activation of mitochondrial apoptotic pathway.
    Title: Mipu1, a novel direct target gene, is involved in hypoxia inducible factor 1-mediated cytoprotection.
  4. The H(2)O(2)-induced up-regulation of Mipu1 in H9c2 cardiomyocytes was mediated by cAMP/PKA-dependent CREB activation.
    Title: Oxidative stress-mediated up-regulation of myocardial ischemic preconditioning up-regulated protein 1 gene expression in H9c2 cardiomyocytes is regulated by cyclic AMP-response element binding protein.
  5. Results found that Mipu1 was highly expressed in the heart and brain of rats and was localized in the nucleus of H9c2 myogenic cells and lay the foundation for further study of the biological functions of Mipu1.
    Title: Tissue expression and subcellular localization of Mipu1, a novel myocardial ischemia-related gene.
  6. These results suggested that Mipu1 protein might act as a transcriptional repressor in mitogen-activated protein kinase (MAPK) signaling pathway to mediate cellular functions
    Title: Mipu1, a novel rat zinc-finger protein, inhibits transcriptional activities of AP-1 and SRE in mitogen-activated protein kinase signaling pathway.
  7. Results indicate that the GC boxes are essential for the activity of the Mipu1 minimal promoter activity
    Title: Identification and characterization of the minimal promoter of Mipu1: the role of GC boxes in the regulation of basal transcription.
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General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables DNA-binding transcription factor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in regulation of DNA-templated transcription IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
zinc finger protein 667
Names
myocardial ischemic preconditioning up-regulated protein 1
myocardial ischemic preconditioning upregulated 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001008557.1 → NP_001008557.1  zinc finger protein 667

    See identical proteins and their annotated locations for NP_001008557.1

    Status: VALIDATED

    Source sequence(s)
    AY221750
    UniProtKB/Swiss-Prot
    Q5MYW4
    Related
    ENSRNOP00000061115.4, ENSRNOT00000063956.5
    Conserved Domains (5) summary
    smart00349
    Location:14 → 74
    KRAB; krueppel associated box
    COG5048
    Location:141 → 599
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:499 → 519
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam01352
    Location:14 → 53
    KRAB; KRAB box
    pfam13465
    Location:456 → 480
    zf-H2C2_2; Zinc-finger double domain

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086019.1 Reference GRCr8

    Range
    76634897..76655133 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006228189.4 → XP_006228251.1  zinc finger protein 667 isoform X1

    See identical proteins and their annotated locations for XP_006228251.1

    UniProtKB/Swiss-Prot
    Q5MYW4
    Conserved Domains (5) summary
    smart00349
    Location:14 → 74
    KRAB; krueppel associated box
    COG5048
    Location:141 → 599
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:499 → 519
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam01352
    Location:14 → 53
    KRAB; KRAB box
    pfam13465
    Location:456 → 480
    zf-H2C2_2; Zinc-finger double domain
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q5MYW4.1 GenPept UniProtKB/Swiss-Prot:Q5MYW4

Gene LinkOut

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Chemical Information
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