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Zfp110 zinc finger protein 110 [ Rattus norvegicus (Norway rat) ]

Gene ID: 308362, updated on 28-Oct-2024

Summary

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Official Symbol
Zfp110provided by RGD
Official Full Name
zinc finger protein 110provided by RGD
Primary source
RGD:1306339
See related
EnsemblRapid:ENSRNOG00000031328 AllianceGenome:RGD:1306339
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Nrif1
Summary
Predicted to enable several functions, including DNA-binding transcription factor activity, RNA polymerase II-specific; RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; and neurotrophin p75 receptor binding activity. Predicted to be involved in several processes, including neuron apoptotic process; regulation of JNK cascade; and regulation of transcription by RNA polymerase II. Predicted to act upstream of or within extrinsic apoptotic signaling pathway and retinal cell apoptotic process. Predicted to be located in cytoplasm and nucleus. Orthologous to human ZNF274 (zinc finger protein 274). [provided by Alliance of Genome Resources, Oct 2024]
Expression
Biased expression in Adrenal (RPKM 147.7), Thymus (RPKM 145.7) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Zfp110 in Genome Data Viewer
Location:
1q21
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (82509563..82533294)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (73445303..73461112)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (65741769..65757709, complement)

Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene vomeronasal 2 receptor, 36 Neighboring gene microRNA 295-2 Neighboring gene zinc finger and SCAN domain containing 18 Neighboring gene zinc finger protein 329 Neighboring gene zinc finger protein 8 Neighboring gene zinc finger and SCAN domain containing 22

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Neurotrophin receptor interacting factor (NRIF) is an essential mediator of apoptotic signaling by the p75 neurotrophin receptor. Linggi MS, et al. J Biol Chem, 2005 Apr 8. PMID 15668238
  2. Strain-specific complementation between NRIF1 and NRIF2, two zinc finger proteins sharing structural and biochemical properties. Benzel I, et al. Gene, 2001 Dec 27. PMID 11750124
  3. ZNF274 recruits the histone methyltransferase SETDB1 to the 3' ends of ZNF genes. Frietze S, et al. PLoS One, 2010 Dec 8. PMID 21170338, Free PMC Article
  4. The zinc finger protein NRIF interacts with the neurotrophin receptor p75(NTR) and participates in programmed cell death. Casademunt E, et al. EMBO J, 1999 Nov 1. PMID 10545116, Free PMC Article
  5. ATRX binds to atypical chromatin domains at the 3' exons of zinc finger genes to preserve H3K9me3 enrichment. Valle-García D, et al. Epigenetics, 2016 Jun 2. PMID 27029610, Free PMC Article

See all (8) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables chromatin binding ISO
Inferred from Sequence Orthology
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables neurotrophin p75 receptor binding ISO
Inferred from Sequence Orthology
more info
  
enables sequence-specific DNA binding ISO
Inferred from Sequence Orthology
more info
  
enables sequence-specific double-stranded DNA binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in chromatin remodeling ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within extrinsic apoptotic signaling pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in neuron apoptotic process ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of DNA-templated transcription IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of JNK cascade ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within retinal cell apoptotic process ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in nucleolus IEA
Inferred from Electronic Annotation
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
neurotrophin receptor-interacting factor 1
Names
zinc finger protein 274

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001024775.1 → NP_001019946.1  neurotrophin receptor-interacting factor 1

    See identical proteins and their annotated locations for NP_001019946.1

    Status: PROVISIONAL

    Source sequence(s)
    BC097420
    UniProtKB/Swiss-Prot
    Q4V8E9
    UniProtKB/TrEMBL
    A0A8L2UK63
    Conserved Domains (9) summary
    smart00431
    Location:157 → 285
    SCAN; leucine rich region
    smart00349
    Location:14 → 73
    KRAB; krueppel associated box
    COG5048
    Location:704 → 761
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:736 → 756
    ZF_C2H2; C2H2 Zn finger [structural motif]
    sd00019
    Location:653 → 672
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:762 → 784
    zf-C2H2; Zinc finger, C2H2 type
    pfam01352
    Location:278 → 317
    KRAB; KRAB box
    pfam02023
    Location:157 → 240
    SCAN; SCAN domain
    pfam13465
    Location:776 → 801
    zf-H2C2_2; Zinc-finger double domain

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086019.1 Reference GRCr8

    Range
    82509563..82533294
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006228111.5 → XP_006228173.1  neurotrophin receptor-interacting factor 1 isoform X1

    UniProtKB/TrEMBL
    A0A8L2UK63
    Related
    ENSRNOP00000105204.1, ENSRNOT00000161731.1
    Conserved Domains (9) summary
    smart00431
    Location:200 → 328
    SCAN; leucine rich region
    smart00349
    Location:57 → 116
    KRAB; krueppel associated box
    COG5048
    Location:747 → 804
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:779 → 799
    ZF_C2H2; C2H2 Zn finger [structural motif]
    sd00019
    Location:696 → 715
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:805 → 827
    zf-C2H2; Zinc finger, C2H2 type
    pfam01352
    Location:321 → 360
    KRAB; KRAB box
    pfam02023
    Location:200 → 283
    SCAN; SCAN domain
    pfam13465
    Location:819 → 844
    zf-H2C2_2; Zinc-finger double domain

  2. XM_017589113.3 → XP_017444602.1  neurotrophin receptor-interacting factor 1 isoform X3

  3. XM_006228112.5 → XP_006228174.1  neurotrophin receptor-interacting factor 1 isoform X2

    See identical proteins and their annotated locations for XP_006228174.1

    UniProtKB/Swiss-Prot
    Q4V8E9
    UniProtKB/TrEMBL
    A0A8L2UK63
    Related
    ENSRNOP00000026298.7, ENSRNOT00000026298.7
    Conserved Domains (9) summary
    smart00431
    Location:157 → 285
    SCAN; leucine rich region
    smart00349
    Location:14 → 73
    KRAB; krueppel associated box
    COG5048
    Location:704 → 761
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:736 → 756
    ZF_C2H2; C2H2 Zn finger [structural motif]
    sd00019
    Location:653 → 672
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:762 → 784
    zf-C2H2; Zinc finger, C2H2 type
    pfam01352
    Location:278 → 317
    KRAB; KRAB box
    pfam02023
    Location:157 → 240
    SCAN; SCAN domain
    pfam13465
    Location:776 → 801
    zf-H2C2_2; Zinc-finger double domain

  4. XM_063261278.1 → XP_063117348.1  neurotrophin receptor-interacting factor 1 isoform X4

  5. XM_063261277.1 → XP_063117347.1  neurotrophin receptor-interacting factor 1 isoform X4

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q4V8E9.1 GenPept UniProtKB/Swiss-Prot:Q4V8E9

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