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Opa3 outer mitochondrial membrane lipid metabolism regulator OPA3 [ Rattus norvegicus (Norway rat) ]

Gene ID: 308409, updated on 2-Nov-2024

Summary

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Symbol
Opa3provided by RGD
Full Name
outer mitochondrial membrane lipid metabolism regulator OPA3provided by RGD
Primary source
RGD:1309147
See related
EnsemblRapid:ENSRNOG00000064373 AllianceGenome:RGD:1309147
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to be involved in visual perception. Predicted to act upstream of or within several processes, including bone development; fat cell differentiation; and neuromuscular process. Predicted to be located in mitochondrion. Human ortholog(s) of this gene implicated in 3-methylglutaconic aciduria type 3 and optic atrophy 3. Orthologous to human OPA3 (outer mitochondrial membrane lipid metabolism regulator OPA3). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Heart (RPKM 177.8), Muscle (RPKM 132.0) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Opa3 in Genome Data Viewer
Location:
1q21
Exon count:
3
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (88007707..88037639)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (78879612..78910453)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (80141630..80160145)

Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene EMAP like 2 Neighboring gene microRNA 330 Neighboring gene G protein-coupled receptor 4 Neighboring gene vasodilator-stimulated phosphoprotein Neighboring gene protein phosphatase, Mg2+/Mn2+ dependent 1N

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Opa3, a novel regulator of mitochondrial function, controls thermogenesis and abdominal fat mass in a mouse model for Costeff syndrome. Wells T, et al. Hum Mol Genet, 2012 Nov 15. PMID 22869679
  2. OPA3 gene mutations responsible for autosomal dominant optic atrophy and cataract. Reynier P, et al. J Med Genet, 2004 Sep. PMID 15342707, Free PMC Article
  3. A missense mutation in the murine Opa3 gene models human Costeff syndrome. Davies VJ, et al. Brain, 2008 Feb. PMID 18222992
  4. Mitochondrial localization and ocular expression of mutant Opa3 in a mouse model of 3-methylglutaconicaciduria type III. Powell KA, et al. Invest Ophthalmol Vis Sci, 2011 Jun 21. PMID 21613372
  5. A mitochondrial protein compendium elucidates complex I disease biology. Pagliarini DJ, et al. Cell, 2008 Jul 11. PMID 18614015, Free PMC Article

See all (6) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
  
acts_upstream_of_or_within bone development ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within fat cell differentiation ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within mitochondrion organization ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within neuromuscular process ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within regulation of growth ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within regulation of lipid metabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in visual perception ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in mitochondrion ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
optic atrophy 3 protein
Names
OPA3, outer mitochondrial membrane lipid metabolism regulator
optic atrophy 3 protein homolog

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001399653.1 → NP_001386582.1  optic atrophy 3 protein

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000001

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086019.1 Reference GRCr8

    Range
    88007707..88037639
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017589999.3 → XP_017445488.2  optic atrophy 3 protein isoform X1

    UniProtKB/TrEMBL
    A0A8I6AQB7, A0A8I6AQX4
    Related
    ENSRNOP00000097116.1, ENSRNOT00000099247.2
    Conserved Domains (1) summary
    pfam07047
    Location:6 → 129
    OPA3; Optic atrophy 3 protein (OPA3)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001107486.1: Suppressed sequence

    Description
    NM_001107486.1: This RefSeq was removed because currently there is support for the transcript but not for the protein.
Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

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