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Kdm2b lysine (K)-specific demethylase 2B [ Mus musculus (house mouse) ]

Gene ID: 30841, updated on 2-Nov-2024

Summary

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Official Symbol
Kdm2bprovided by MGI
Official Full Name
lysine (K)-specific demethylase 2Bprovided by MGI
Primary source
MGI:MGI:1354737
See related
Ensembl:ENSMUSG00000029475 AllianceGenome:MGI:1354737
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Cxxc2; Fbl10; PCCX2; Fbxl10; Jhdm1b
Summary
The protein encoded by this gene is a H3K36-specific histone demethylase, which contains an N-terminal jumonji C domain, a CxxC zinc finger domain, a plant homeodomain finger, an F-box, and eight leucine-rich repeats. Amongst its demonstrated functions, this protein plays roles in the suppression of premature cellular senescence, leukemia maintenance and development, maintenance of mouse embryonic stem cell pluripotency, and induced pluripotent stem cell generation. Mice homozygous for a targeted deletion of the zinc finger domain display embryonic lethality with development ceasing at approximately 7 to 8 days post coitum, demonstrating an essential role in early development. A pseudogene of this gene is found on chromosome 4. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2014]
Expression
Ubiquitous expression in CNS E14 (RPKM 10.9), whole brain E14.5 (RPKM 10.7) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See Kdm2b in Genome Data Viewer
Location:
5 F; 5 62.63 cM
Exon count:
30
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (123008727..123127333, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (122870664..122989270, complement)

Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E2762 Neighboring gene predicted gene, 33044 Neighboring gene ring finger protein 34 Neighboring gene STARR-seq mESC enhancer starr_14301 Neighboring gene STARR-positive B cell enhancer ABC_E3615 Neighboring gene predicted gene, 33118 Neighboring gene RIKEN cDNA A930024E05 gene Neighboring gene STARR-seq mESC enhancer starr_14304 Neighboring gene STARR-positive B cell enhancer ABC_E3616 Neighboring gene predicted gene 2479

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Enhanced direct conversion of fibroblasts into hepatocyte-like cells by Kdm2b. Zakikhan K, et al. Biochem Biophys Res Commun, 2016 May 20. PMID 27103435
  2. Overexpression of histone demethylase Fbxl10 leads to enhanced migration in mouse embryonic fibroblasts. Rohde M, et al. Exp Cell Res, 2016 Nov 1. PMID 27646113
  3. FBXL10 protects Polycomb-bound genes from hypermethylation. Boulard M, et al. Nat Genet, 2015 May. PMID 25848754
  4. Secondary DNA structure formation for Hoxb9 promoter and identification of its specific binding protein. Yamagishi T, et al. Nucleic Acids Res, 2008 Apr. PMID 18276649, Free PMC Article
  5. The JmjC domain histone demethylase Ndy1 regulates redox homeostasis and protects cells from oxidative stress. Polytarchou C, et al. Mol Cell Biol, 2008 Dec. PMID 18838535, Free PMC Article

See all (72) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. KDM2B regulates hippocampal morphogenesis by transcriptionally silencing Wnt signaling in neural progenitors.
    Title: KDM2B regulates hippocampal morphogenesis by transcriptionally silencing Wnt signaling in neural progenitors.
  2. KDM2B promotes IL-6 production and inflammatory responses through Brg1-mediated chromatin remodeling.
    Title: KDM2B promotes IL-6 production and inflammatory responses through Brg1-mediated chromatin remodeling.
  3. Identification of Structural Elements of the Lysine Specific Demethylase 2B CxxC Domain Associated with Replicative Senescence Bypass in Primary Mouse Cells.
    Title: Identification of Structural Elements of the Lysine Specific Demethylase 2B CxxC Domain Associated with Replicative Senescence Bypass in Primary Mouse Cells.
  4. Long non-coding RNA LncKdm2b regulates cortical neuronal differentiation by cis-activating Kdm2b.
    Title: Long non-coding RNA LncKdm2b regulates cortical neuronal differentiation by cis-activating Kdm2b.
  5. KDM2B in polycomb repressive complex 1.1 functions as a tumor suppressor in the initiation of T-cell leukemogenesis.
    Title: KDM2B in polycomb repressive complex 1.1 functions as a tumor suppressor in the initiation of T-cell leukemogenesis.
  6. KDM2 proteins play a widespread and demethylase-independent role in constraining gene expression from CpG islands CGI)-associated gene promoters. KDM2 proteins shape RNA Polymerase II occupancy but not chromatin accessibility at CGI-associated promoters.
    Title: KDM2 proteins constrain transcription from CpG island gene promoters independently of their histone demethylase activity.
  7. tthat bone morphogenetic protein (BMP) represses Oct4/Kdm2b-induced somatic reprogramming selectively
    Title: Kdm2b Regulates Somatic Reprogramming through Variant PRC1 Complex-Dependent Function.
  8. Fbxl10 plays a critical role in migration by binding to the promoter region of migration-associated genes and thereby might influences cell behaviour to a possibly more aggressive phenotype.
    Title: Overexpression of histone demethylase Fbxl10 leads to enhanced migration in mouse embryonic fibroblasts.
  9. These results have not only identified an important epigenetic factor for iHep generation, but also brought new insight into the molecular nature of hepatogenesis and future biomedical applications for liver diseases.
    Title: Enhanced direct conversion of fibroblasts into hepatocyte-like cells by Kdm2b.
  10. this study shows that long noncoding RNA Kdm2b expression sustains the maintenance of Innate lymphoid cells by promoting their proliferation through activation of the transcription factor Zfp292
    Title: Long noncoding RNA lncKdm2b is required for ILC3 maintenance by initiation of Zfp292 expression.
Submit: New GeneRIF Correction See all GeneRIFs (24)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • KIAA3014, E430001G17

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables histone H3K36 demethylase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables histone H3K36 demethylase activity ISO
Inferred from Sequence Orthology
more info
  
enables histone H3K36 demethylase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables histone H3K36me/H3K36me2 demethylase activity IEA
Inferred from Electronic Annotation
more info
  
enables histone demethylase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables histone demethylase activity TAS
Traceable Author Statement
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables rRNA binding IEA
Inferred from Electronic Annotation
more info
  
enables transcription coregulator activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables unmethylated CpG binding ISO
Inferred from Sequence Orthology
more info
  
enables unmethylated CpG binding ISS
Inferred from Sequence or Structural Similarity
more info
  
enables zinc ion binding ISO
Inferred from Sequence Orthology
more info
  
enables zinc ion binding ISS
Inferred from Sequence or Structural Similarity
more info
  
Process Evidence Code Pubs
involved_in chromatin remodeling IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in chromatin remodeling IEA
Inferred from Electronic Annotation
more info
  
involved_in chromatin remodeling ISO
Inferred from Sequence Orthology
more info
  
involved_in embryonic camera-type eye morphogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in forebrain development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in fourth ventricle development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in hindbrain development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in initiation of neural tube closure IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in lateral ventricle development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in midbrain development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in midbrain-hindbrain boundary morphogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of neural precursor cell proliferation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of neuron apoptotic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within negative regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in negative regulation of transcription by RNA polymerase II IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within positive regulation of cell growth IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within positive regulation of stem cell population maintenance IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in spermatogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in third ventricle development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
part_of PcG protein complex IEA
Inferred from Electronic Annotation
more info
  
part_of PcG protein complex ISO
Inferred from Sequence Orthology
more info
  
located_in chromosome IEA
Inferred from Electronic Annotation
more info
  
located_in nucleolus IEA
Inferred from Electronic Annotation
more info
  
located_in nucleoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
lysine-specific demethylase 2B
Names
F-box and leucine-rich repeat protein 10
F-box protein FBL10
F-box protein containing leucine repeats 10
F-box/LRR-repeat protein 10
[Histone-H3]-lysine-36 demethylase 1B
jmjC domain-containing histone demethylation protein 1B
NP_001003953.1
NP_001365792.1
NP_001365793.1
NP_001365794.1
NP_038938.1
XP_006530439.1
XP_011246510.1
XP_011246511.1
XP_011246512.1
XP_011246513.1
XP_011246514.1
XP_011246515.1
XP_011246516.1
XP_011246517.1
XP_011246518.1
XP_036021058.1
XP_036021059.1
XP_036021060.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001003953.2 → NP_001003953.1  lysine-specific demethylase 2B isoform 1

    See identical proteins and their annotated locations for NP_001003953.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (1).
    Source sequence(s)
    AK136625, BC065090
    Consensus CDS
    CCDS39259.1
    UniProtKB/Swiss-Prot
    Q3V396, Q6P1G2, Q6PFD0, Q6ZPE8, Q9CSF7, Q9QZN6
    UniProtKB/TrEMBL
    D3YVU7
    Related
    ENSMUSP00000038229.10, ENSMUST00000046073.16
    Conserved Domains (7) summary
    cd09293
    Location:1080 → 1280
    AMN1; Antagonist of mitotic exit network protein 1
    smart00558
    Location:151 → 226
    JmjC; A domain family that is part of the cupin metalloenzyme superfamily
    pfam02008
    Location:588 → 624
    zf-CXXC; CXXC zinc finger domain
    sd00034
    Location:1075 → 1099
    LRR_AMN1; leucine-rich repeat [structural motif]
    cd15644
    Location:634 → 695
    PHD_KDM2B; PHD finger found in Lysine-specific demethylase 2B (KDM2B)
    pfam12937
    Location:1041 → 1081
    F-box-like; F-box-like
    cl21464
    Location:198 → 304
    cupin_like; Conserved domain found in cupin and related proteins

  2. NM_001378863.1 → NP_001365792.1  lysine-specific demethylase 2B isoform 3

    Status: REVIEWED

    Source sequence(s)
    AC121564
    UniProtKB/TrEMBL
    D3YVU7, E9QL25
    Related
    ENSMUSP00000083376.5, ENSMUST00000086200.11
    Conserved Domains (10) summary
    PTZ00449
    Location:687 → 986
    PTZ00449; 104 kDa microneme/rhoptry antigen; Provisional
    cd09293
    Location:1074 → 1274
    AMN1; Antagonist of mitotic exit network protein 1
    smart00558
    Location:145 → 220
    JmjC; A domain family that is part of the cupin metalloenzyme superfamily
    sd00034
    Location:1069 → 1093
    LRR_AMN1; leucine-rich repeat [structural motif]
    cd15644
    Location:628 → 689
    PHD_KDM2B; PHD finger found in Lysine-specific demethylase 2B (KDM2B)
    pfam02008
    Location:582 → 618
    zf-CXXC; CXXC zinc finger domain
    pfam12937
    Location:1035 → 1073
    F-box-like
    pfam17811
    Location:297 → 332
    JHD; Jumonji helical domain
    cl40423
    Location:192 → 298
    cupin_RmlC-like; RmlC-like cupin superfamily
    cl40435
    Location:474 → 540
    CTD_KDM2A_2B-like; C-terminal domain found in lysine-specific demethylase KDM2A, KDM2B, and similar proteins

  3. NM_001378864.1 → NP_001365793.1  lysine-specific demethylase 2B isoform 4

    Status: REVIEWED

    Source sequence(s)
    AC121564
    Conserved Domains (6) summary
    PTZ00449
    Location:160 → 462
    PTZ00449; 104 kDa microneme/rhoptry antigen; Provisional
    cd09293
    Location:561 → 750
    AMN1; Antagonist of mitotic exit network protein 1
    sd00034
    Location:545 → 569
    LRR_AMN1; leucine-rich repeat [structural motif]
    cd15644
    Location:101 → 162
    PHD_KDM2B; PHD finger found in Lysine-specific demethylase 2B (KDM2B)
    pfam02008
    Location:55 → 91
    zf-CXXC; CXXC zinc finger domain
    pfam12937
    Location:511 → 549
    F-box-like

  4. NM_001378865.1 → NP_001365794.1  lysine-specific demethylase 2B isoform 5

    Status: REVIEWED

    Source sequence(s)
    AC121564
    Conserved Domains (5) summary
    cd09293
    Location:520 → 709
    AMN1; Antagonist of mitotic exit network protein 1
    sd00034
    Location:504 → 528
    LRR_AMN1; leucine-rich repeat [structural motif]
    cd15644
    Location:101 → 162
    PHD_KDM2B; PHD finger found in Lysine-specific demethylase 2B (KDM2B)
    pfam02008
    Location:55 → 91
    zf-CXXC; CXXC zinc finger domain
    pfam12937
    Location:470 → 508
    F-box-like

  5. NM_013910.2 → NP_038938.1  lysine-specific demethylase 2B isoform 2

    See identical proteins and their annotated locations for NP_038938.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks exons in the 5' UTR and 5' coding region and uses an alternate 5' terminal exon compared to variant 1. The encoded isoform (2) has a distinct N-terminus and is shorter than isoform 1.
    Source sequence(s)
    BC057622, BC065090, BU841175
    Consensus CDS
    CCDS19657.1
    UniProtKB/Swiss-Prot
    Q6P1G2
    Related
    ENSMUSP00000031435.8, ENSMUST00000031435.14
    Conserved Domains (5) summary
    cd09293
    Location:558 → 747
    AMN1; Antagonist of mitotic exit network protein 1
    pfam02008
    Location:55 → 91
    zf-CXXC; CXXC zinc finger domain
    sd00034
    Location:542 → 566
    LRR_AMN1; leucine-rich repeat [structural motif]
    cd15644
    Location:101 → 162
    PHD_KDM2B; PHD finger found in Lysine-specific demethylase 2B (KDM2B)
    pfam12937
    Location:508 → 548
    F-box-like; F-box-like

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000071.7 Reference GRCm39 C57BL/6J

    Range
    123008727..123127333 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006530376.4 → XP_006530439.1  lysine-specific demethylase 2B isoform X4

    UniProtKB/TrEMBL
    D3YVU4
    Related
    ENSMUSP00000114052.3, ENSMUST00000118027.8
    Conserved Domains (9) summary
    cd09293
    Location:1042 → 1242
    AMN1; Antagonist of mitotic exit network protein 1
    smart00558
    Location:151 → 226
    JmjC; A domain family that is part of the cupin metalloenzyme superfamily
    sd00034
    Location:1037 → 1061
    LRR_AMN1; leucine-rich repeat [structural motif]
    cd15644
    Location:634 → 695
    PHD_KDM2B; PHD finger found in Lysine-specific demethylase 2B (KDM2B)
    pfam02008
    Location:588 → 624
    zf-CXXC; CXXC zinc finger domain
    pfam10477
    Location:718 → 922
    EIF4E-T; Nucleocytoplasmic shuttling protein for mRNA cap-binding EIF4E
    pfam12937
    Location:1003 → 1041
    F-box-like
    pfam17811
    Location:303 → 338
    JHD; Jumonji helical domain
    cl21464
    Location:198 → 297
    cupin_like; Conserved domain found in cupin and related proteins

  2. XM_011248210.3 → XP_011246512.1  lysine-specific demethylase 2B isoform X3

    UniProtKB/TrEMBL
    D3YVU4
    Conserved Domains (9) summary
    cd09293
    Location:1045 → 1245
    AMN1; Antagonist of mitotic exit network protein 1
    smart00558
    Location:151 → 226
    JmjC; A domain family that is part of the cupin metalloenzyme superfamily
    sd00034
    Location:1040 → 1064
    LRR_AMN1; leucine-rich repeat [structural motif]
    cd15644
    Location:634 → 695
    PHD_KDM2B; PHD finger found in Lysine-specific demethylase 2B (KDM2B)
    pfam02008
    Location:588 → 624
    zf-CXXC; CXXC zinc finger domain
    pfam10477
    Location:721 → 925
    EIF4E-T; Nucleocytoplasmic shuttling protein for mRNA cap-binding EIF4E
    pfam12937
    Location:1006 → 1044
    F-box-like
    pfam17811
    Location:303 → 338
    JHD; Jumonji helical domain
    cl21464
    Location:198 → 297
    cupin_like; Conserved domain found in cupin and related proteins

  3. XM_011248208.3 → XP_011246510.1  lysine-specific demethylase 2B isoform X1

    UniProtKB/TrEMBL
    D3YVU7
    Conserved Domains (9) summary
    PTZ00449
    Location:693 → 995
    PTZ00449; 104 kDa microneme/rhoptry antigen; Provisional
    cd09293
    Location:1083 → 1283
    AMN1; Antagonist of mitotic exit network protein 1
    smart00558
    Location:151 → 226
    JmjC; A domain family that is part of the cupin metalloenzyme superfamily
    sd00034
    Location:1078 → 1102
    LRR_AMN1; leucine-rich repeat [structural motif]
    cd15644
    Location:634 → 695
    PHD_KDM2B; PHD finger found in Lysine-specific demethylase 2B (KDM2B)
    pfam02008
    Location:588 → 624
    zf-CXXC; CXXC zinc finger domain
    pfam12937
    Location:1044 → 1082
    F-box-like
    pfam17811
    Location:303 → 338
    JHD; Jumonji helical domain
    cl21464
    Location:198 → 297
    cupin_like; Conserved domain found in cupin and related proteins

  4. XM_011248212.4 → XP_011246514.1  lysine-specific demethylase 2B isoform X5

    See identical proteins and their annotated locations for XP_011246514.1

    UniProtKB/TrEMBL
    D3YVU7
    Related
    ENSMUSP00000114049.2, ENSMUST00000121739.8
    Conserved Domains (9) summary
    PTZ00449
    Location:638 → 940
    PTZ00449; 104 kDa microneme/rhoptry antigen; Provisional
    cd09293
    Location:1028 → 1228
    AMN1; Antagonist of mitotic exit network protein 1
    smart00558
    Location:96 → 171
    JmjC; A domain family that is part of the cupin metalloenzyme superfamily
    sd00034
    Location:1023 → 1047
    LRR_AMN1; leucine-rich repeat [structural motif]
    cd15644
    Location:579 → 640
    PHD_KDM2B; PHD finger found in Lysine-specific demethylase 2B (KDM2B)
    pfam02008
    Location:533 → 569
    zf-CXXC; CXXC zinc finger domain
    pfam12937
    Location:989 → 1027
    F-box-like
    pfam17811
    Location:248 → 283
    JHD; Jumonji helical domain
    cl21464
    Location:143 → 242
    cupin_like; Conserved domain found in cupin and related proteins

  5. XM_011248211.4 → XP_011246513.1  lysine-specific demethylase 2B isoform X5

    See identical proteins and their annotated locations for XP_011246513.1

    UniProtKB/TrEMBL
    D3YVU7
    Conserved Domains (9) summary
    PTZ00449
    Location:638 → 940
    PTZ00449; 104 kDa microneme/rhoptry antigen; Provisional
    cd09293
    Location:1028 → 1228
    AMN1; Antagonist of mitotic exit network protein 1
    smart00558
    Location:96 → 171
    JmjC; A domain family that is part of the cupin metalloenzyme superfamily
    sd00034
    Location:1023 → 1047
    LRR_AMN1; leucine-rich repeat [structural motif]
    cd15644
    Location:579 → 640
    PHD_KDM2B; PHD finger found in Lysine-specific demethylase 2B (KDM2B)
    pfam02008
    Location:533 → 569
    zf-CXXC; CXXC zinc finger domain
    pfam12937
    Location:989 → 1027
    F-box-like
    pfam17811
    Location:248 → 283
    JHD; Jumonji helical domain
    cl21464
    Location:143 → 242
    cupin_like; Conserved domain found in cupin and related proteins

  6. XM_011248209.4 → XP_011246511.1  lysine-specific demethylase 2B isoform X2

    UniProtKB/TrEMBL
    D3YVU7
    Conserved Domains (9) summary
    PTZ00449
    Location:687 → 989
    PTZ00449; 104 kDa microneme/rhoptry antigen; Provisional
    cd09293
    Location:1077 → 1277
    AMN1; Antagonist of mitotic exit network protein 1
    smart00558
    Location:145 → 220
    JmjC; A domain family that is part of the cupin metalloenzyme superfamily
    sd00034
    Location:1072 → 1096
    LRR_AMN1; leucine-rich repeat [structural motif]
    cd15644
    Location:628 → 689
    PHD_KDM2B; PHD finger found in Lysine-specific demethylase 2B (KDM2B)
    pfam02008
    Location:582 → 618
    zf-CXXC; CXXC zinc finger domain
    pfam12937
    Location:1038 → 1076
    F-box-like
    pfam17811
    Location:297 → 332
    JHD; Jumonji helical domain
    cl21464
    Location:192 → 291
    cupin_like; Conserved domain found in cupin and related proteins

  7. XM_011248215.2 → XP_011246517.1  lysine-specific demethylase 2B isoform X8

    UniProtKB/TrEMBL
    D3YVU7
    Conserved Domains (9) summary
    PTZ00449
    Location:607 → 909
    PTZ00449; 104 kDa microneme/rhoptry antigen; Provisional
    cd09293
    Location:997 → 1197
    AMN1; Antagonist of mitotic exit network protein 1
    smart00558
    Location:65 → 140
    JmjC; A domain family that is part of the cupin metalloenzyme superfamily
    sd00034
    Location:992 → 1016
    LRR_AMN1; leucine-rich repeat [structural motif]
    cd15644
    Location:548 → 609
    PHD_KDM2B; PHD finger found in Lysine-specific demethylase 2B (KDM2B)
    pfam02008
    Location:502 → 538
    zf-CXXC; CXXC zinc finger domain
    pfam12937
    Location:958 → 996
    F-box-like
    pfam17811
    Location:217 → 252
    JHD; Jumonji helical domain
    cl21464
    Location:112 → 211
    cupin_like; Conserved domain found in cupin and related proteins

  8. XM_036165165.1 → XP_036021058.1  lysine-specific demethylase 2B isoform X7

    UniProtKB/TrEMBL
    D3YVU7
    Conserved Domains (9) summary
    PTZ00449
    Location:493 → 792
    PTZ00449; 104 kDa microneme/rhoptry antigen; Provisional
    cd09293
    Location:880 → 1080
    AMN1; Antagonist of mitotic exit network protein 1
    sd00034
    Location:875 → 899
    LRR_AMN1; leucine-rich repeat [structural motif]
    cd15644
    Location:434 → 495
    PHD_KDM2B; PHD finger found in Lysine-specific demethylase 2B (KDM2B)
    pfam02008
    Location:388 → 424
    zf-CXXC; CXXC zinc finger domain
    pfam12937
    Location:841 → 879
    F-box-like
    pfam17811
    Location:103 → 138
    JHD; Jumonji helical domain
    cd21785
    Location:280 → 346
    CTD_KDM2B; C-terminal domain found in Lysine-specific demethylase 2B
    cl40423
    Location:1 → 104
    cupin_RmlC-like; RmlC-like cupin superfamily

  9. XM_011248214.3 → XP_011246516.1  lysine-specific demethylase 2B isoform X6

    See identical proteins and their annotated locations for XP_011246516.1

    UniProtKB/TrEMBL
    D3YVU7
    Conserved Domains (8) summary
    PTZ00449
    Location:493 → 795
    PTZ00449; 104 kDa microneme/rhoptry antigen; Provisional
    cd09293
    Location:883 → 1083
    AMN1; Antagonist of mitotic exit network protein 1
    sd00034
    Location:878 → 902
    LRR_AMN1; leucine-rich repeat [structural motif]
    cd15644
    Location:434 → 495
    PHD_KDM2B; PHD finger found in Lysine-specific demethylase 2B (KDM2B)
    pfam02008
    Location:388 → 424
    zf-CXXC; CXXC zinc finger domain
    pfam12937
    Location:844 → 882
    F-box-like
    pfam17811
    Location:103 → 138
    JHD; Jumonji helical domain
    cl21464
    Location:1 → 97
    cupin_like; Conserved domain found in cupin and related proteins

  10. XM_011248213.4 → XP_011246515.1  lysine-specific demethylase 2B isoform X6

    See identical proteins and their annotated locations for XP_011246515.1

    UniProtKB/TrEMBL
    D3YVU7
    Conserved Domains (8) summary
    PTZ00449
    Location:493 → 795
    PTZ00449; 104 kDa microneme/rhoptry antigen; Provisional
    cd09293
    Location:883 → 1083
    AMN1; Antagonist of mitotic exit network protein 1
    sd00034
    Location:878 → 902
    LRR_AMN1; leucine-rich repeat [structural motif]
    cd15644
    Location:434 → 495
    PHD_KDM2B; PHD finger found in Lysine-specific demethylase 2B (KDM2B)
    pfam02008
    Location:388 → 424
    zf-CXXC; CXXC zinc finger domain
    pfam12937
    Location:844 → 882
    F-box-like
    pfam17811
    Location:103 → 138
    JHD; Jumonji helical domain
    cl21464
    Location:1 → 97
    cupin_like; Conserved domain found in cupin and related proteins

  11. XM_011248216.3 → XP_011246518.1  lysine-specific demethylase 2B isoform X6

    See identical proteins and their annotated locations for XP_011246518.1

    UniProtKB/TrEMBL
    D3YVU7
    Conserved Domains (8) summary
    PTZ00449
    Location:493 → 795
    PTZ00449; 104 kDa microneme/rhoptry antigen; Provisional
    cd09293
    Location:883 → 1083
    AMN1; Antagonist of mitotic exit network protein 1
    sd00034
    Location:878 → 902
    LRR_AMN1; leucine-rich repeat [structural motif]
    cd15644
    Location:434 → 495
    PHD_KDM2B; PHD finger found in Lysine-specific demethylase 2B (KDM2B)
    pfam02008
    Location:388 → 424
    zf-CXXC; CXXC zinc finger domain
    pfam12937
    Location:844 → 882
    F-box-like
    pfam17811
    Location:103 → 138
    JHD; Jumonji helical domain
    cl21464
    Location:1 → 97
    cupin_like; Conserved domain found in cupin and related proteins

  12. XM_036165167.1 → XP_036021060.1  lysine-specific demethylase 2B isoform X10

    Conserved Domains (7) summary
    PTZ00449
    Location:363 → 662
    PTZ00449; 104 kDa microneme/rhoptry antigen; Provisional
    cd09293
    Location:750 → 950
    AMN1; Antagonist of mitotic exit network protein 1
    sd00034
    Location:745 → 769
    LRR_AMN1; leucine-rich repeat [structural motif]
    cd15644
    Location:304 → 365
    PHD_KDM2B; PHD finger found in Lysine-specific demethylase 2B (KDM2B)
    pfam02008
    Location:258 → 294
    zf-CXXC; CXXC zinc finger domain
    pfam12937
    Location:711 → 749
    F-box-like
    cd21785
    Location:150 → 216
    CTD_KDM2B; C-terminal domain found in Lysine-specific demethylase 2B

  13. XM_036165166.1 → XP_036021059.1  lysine-specific demethylase 2B isoform X9

    Conserved Domains (7) summary
    PTZ00449
    Location:363 → 665
    PTZ00449; 104 kDa microneme/rhoptry antigen; Provisional
    cd09293
    Location:753 → 953
    AMN1; Antagonist of mitotic exit network protein 1
    sd00034
    Location:748 → 772
    LRR_AMN1; leucine-rich repeat [structural motif]
    cd15644
    Location:304 → 365
    PHD_KDM2B; PHD finger found in Lysine-specific demethylase 2B (KDM2B)
    pfam02008
    Location:258 → 294
    zf-CXXC; CXXC zinc finger domain
    pfam12937
    Location:714 → 752
    F-box-like
    cd21785
    Location:150 → 216
    CTD_KDM2B; C-terminal domain found in Lysine-specific demethylase 2B

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001005866.1: Suppressed sequence

    Description
    NM_001005866.1: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q6P1G2.1 GenPept UniProtKB/Swiss-Prot:Q6P1G2

Gene LinkOut

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