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Uba2 ubiquitin-like modifier activating enzyme 2 [ Rattus norvegicus (Norway rat) ]

Gene ID: 308508, updated on 28-Oct-2024

Summary

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Official Symbol
Uba2provided by RGD
Official Full Name
ubiquitin-like modifier activating enzyme 2provided by RGD
Primary source
RGD:1312023
See related
EnsemblRapid:ENSRNOG00000021113 AllianceGenome:RGD:1312023
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Sae2; Uble1b
Summary
Predicted to enable several functions, including ATP binding activity; SUMO activating enzyme activity; and enzyme binding activity. Predicted to be involved in positive regulation of protein sumoylation and protein sumoylation. Predicted to be located in nucleoplasm. Predicted to be part of SUMO activating enzyme complex. Predicted to be active in cytoplasm. Orthologous to human UBA2 (ubiquitin like modifier activating enzyme 2). [provided by Alliance of Genome Resources, Oct 2024]
Expression
Biased expression in Thymus (RPKM 407.3), Spleen (RPKM 282.8) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Uba2 in Genome Data Viewer
Location:
1q21
Exon count:
19
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (95912422..95939870, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (86775239..86802685, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (90010681..90035522, complement)

Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene secretoglobin, family 1B, member 30 Neighboring gene WT1 interacting protein Neighboring gene small nucleolar RNA SNORA11 Neighboring gene programmed cell death 2-like Neighboring gene glucose-6-phosphate isomerase

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Identification of the enzyme required for activation of the small ubiquitin-like protein SUMO-1. Desterro JM, et al. J Biol Chem, 1999 Apr 9. PMID 10187858
  2. Active site remodelling accompanies thioester bond formation in the SUMO E1. Olsen SK, et al. Nature, 2010 Feb 18. PMID 20164921, Free PMC Article
  3. Ribosomal protein S3 is stabilized by sumoylation. Jang CY, et al. Biochem Biophys Res Commun, 2011 Oct 28. PMID 21968017
  4. Mitotic kinase Aurora-B is regulated by SUMO-2/3 conjugation/deconjugation during mitosis. Ban R, et al. Genes Cells, 2011 Jun. PMID 21554500
  5. Ikaros SUMOylation: switching out of repression. Gómez-del Arco P, et al. Mol Cell Biol, 2005 Apr. PMID 15767674, Free PMC Article

See all (10) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables ATP binding ISO
Inferred from Sequence Orthology
more info
  
enables SUMO activating enzyme activity IBA
Inferred from Biological aspect of Ancestor
more info
  
contributes_to SUMO activating enzyme activity ISO
Inferred from Sequence Orthology
more info
  
enables SUMO activating enzyme activity ISO
Inferred from Sequence Orthology
more info
  
enables SUMO binding ISO
Inferred from Sequence Orthology
more info
  
enables magnesium ion binding ISO
Inferred from Sequence Orthology
more info
  
enables protein heterodimerization activity ISO
Inferred from Sequence Orthology
more info
  
enables small protein activating enzyme binding ISO
Inferred from Sequence Orthology
more info
  
enables ubiquitin-like protein conjugating enzyme binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in positive regulation of protein sumoylation ISO
Inferred from Sequence Orthology
more info
  
involved_in protein sumoylation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein sumoylation IEA
Inferred from Electronic Annotation
more info
  
involved_in protein sumoylation ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
part_of SUMO activating enzyme complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of SUMO activating enzyme complex ISO
Inferred from Sequence Orthology
more info
  
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
SUMO-activating enzyme subunit 2
Names
SUMO1 activating enzyme subunit 2
ubiquitin-like 1 (sentrin) activating enzyme E1B
NP_001094049.1
XP_038967529.1
XP_063117687.1
XP_063117691.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001100579.1 → NP_001094049.1  SUMO-activating enzyme subunit 2

    See identical proteins and their annotated locations for NP_001094049.1

    Status: PROVISIONAL

    Source sequence(s)
    BC161985
    UniProtKB/TrEMBL
    A0A8I6A3Z5, B1WC32
    Related
    ENSRNOP00000028672.9, ENSRNOT00000028672.9
    Conserved Domains (4) summary
    cd01489
    Location:19 → 443
    Uba2_SUMO; Ubiquitin activating enzyme (E1) subunit UBA2. UBA2 is part of the heterodimeric activating enzyme (E1), specific for the SUMO family of ubiquitin-like proteins (Ubls). E1 enzymes are part of a conjugation cascade to attach Ub or Ubls, covalently to ...
    pfam00899
    Location:9 → 175
    ThiF; ThiF family
    pfam14732
    Location:451 → 537
    UAE_UbL; Ubiquitin/SUMO-activating enzyme ubiquitin-like domain
    pfam16195
    Location:548 → 634
    UBA2_C; SUMO-activating enzyme subunit 2 C-terminus

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086019.1 Reference GRCr8

    Range
    95912422..95939870 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063261617.1 → XP_063117687.1  SUMO-activating enzyme subunit 2 isoform X2

    Related
    ENSRNOP00000087889.1, ENSRNOT00000101711.2

  2. XM_039111601.2 → XP_038967529.1  SUMO-activating enzyme subunit 2 isoform X1

    UniProtKB/TrEMBL
    F1LS72
    Related
    ENSRNOP00000109327.1, ENSRNOT00000130156.1
    Conserved Domains (4) summary
    cd01489
    Location:19 → 443
    Uba2_SUMO; Ubiquitin activating enzyme (E1) subunit UBA2. UBA2 is part of the heterodimeric activating enzyme (E1), specific for the SUMO family of ubiquitin-like proteins (Ubls). E1 enzymes are part of a conjugation cascade to attach Ub or Ubls, covalently to ...
    pfam10585
    Location:179 → 361
    UBA_e1_thiolCys; Ubiquitin-activating enzyme active site
    pfam14732
    Location:451 → 537
    UAE_UbL; Ubiquitin/SUMO-activating enzyme ubiquitin-like domain
    pfam16195
    Location:548 → 579
    UBA2_C; SUMO-activating enzyme subunit 2 C-terminus

  3. XM_063261621.1 → XP_063117691.1  SUMO-activating enzyme subunit 2 isoform X3

RNA

  1. XR_010052057.1 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version

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