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Chst8 carbohydrate sulfotransferase 8 [ Rattus norvegicus (Norway rat) ]

Gene ID: 308511, updated on 13-Jul-2024

Summary

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Official Symbol
Chst8provided by RGD
Official Full Name
carbohydrate sulfotransferase 8provided by RGD
Primary source
RGD:1308979
See related
EnsemblRapid:ENSRNOG00000070506 AllianceGenome:RGD:1308979
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable N-acetylgalactosamine 4-O-sulfotransferase activity. Predicted to be involved in hormone biosynthetic process; proteoglycan biosynthetic process; and sulfur compound metabolic process. Predicted to be located in Golgi membrane. Predicted to be integral component of membrane. Human ortholog(s) of this gene implicated in peeling skin syndrome. Orthologous to human CHST8 (carbohydrate sulfotransferase 8). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Brain (RPKM 16.9), Kidney (RPKM 4.6) and 3 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Chst8 in Genome Data Viewer
Location:
1q21
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (96431144..96572880, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (87294144..87435900, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (90542095..90685257, complement)

Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC100910905 Neighboring gene potassium channel tetramerization domain containing 15 Neighboring gene uncharacterized LOC108349467 Neighboring gene uncharacterized LOC134483097 Neighboring gene NADH:ubiquinone oxidoreductase subunit B4 like 3 Neighboring gene small nucleolar RNA SNORA17 Neighboring gene peptidase D

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Molecular cloning and characterization of GalNAc 4-sulfotransferase expressed in human pituitary gland. Okuda T, et al. J Biol Chem, 2000 Dec 22. PMID 11001942
  2. Mouse N-acetylgalactosamine 4-sulfotransferases-1 and -2. Molecular cloning, expression, chromosomal mapping and detection of their activity with GalNAcbeta1-4GlcNAcbeta1-octyl. Okuda T, et al. J Biochem, 2003 Jul. PMID 12944377
  3. Molecular cloning and expression of the pituitary glycoprotein hormone N-acetylgalactosamine-4-O-sulfotransferase. Xia G, et al. J Biol Chem, 2000 Dec 8. PMID 10988300
  4. Molecular cloning and expression of two distinct human N-acetylgalactosamine 4-O-sulfotransferases that transfer sulfate to GalNAc beta 1-->4GlcNAc beta 1-->R in both N- and O-glycans. Hiraoka N, et al. Glycobiology, 2001 Jun. PMID 11445554
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

See all (6) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables N-acetylgalactosamine 4-O-sulfotransferase activity ISO
Inferred from Sequence Orthology
more info
  
enables sulfotransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in hormone biosynthetic process ISO
Inferred from Sequence Orthology
more info
  
involved_in proteoglycan biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within proteoglycan biosynthetic process ISO
Inferred from Sequence Orthology
more info
  
involved_in proteoglycan biosynthetic process ISO
Inferred from Sequence Orthology
more info
  
involved_in sulfur compound metabolic process ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
carbohydrate sulfotransferase 8
Names
carbohydrate (N-acetylgalactosamine 4-0) sulfotransferase 8
NP_001100974.1
XP_063117731.1
XP_063117732.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001107504.2 → NP_001100974.1  carbohydrate sulfotransferase 8

    See identical proteins and their annotated locations for NP_001100974.1

    Status: PROVISIONAL

    Source sequence(s)
    BC161905
    UniProtKB/TrEMBL
    B1WBV7
    Related
    ENSRNOP00000107768.1, ENSRNOT00000156329.1
    Conserved Domains (1) summary
    pfam03567
    Location:180 → 409
    Sulfotransfer_2; Sulfotransferase family

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086019.1 Reference GRCr8

    Range
    96431144..96572880 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063261662.1 → XP_063117732.1  carbohydrate sulfotransferase 8 isoform X1

    UniProtKB/TrEMBL
    B1WBV7

  2. XM_063261661.1 → XP_063117731.1  carbohydrate sulfotransferase 8 isoform X1

    UniProtKB/TrEMBL
    B1WBV7
Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

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