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Heca hdc homolog, cell cycle regulator [ Rattus norvegicus (Norway rat) ]

Gene ID: 308624, updated on 2-Nov-2024

Summary

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Official Symbol
Hecaprovided by RGD
Official Full Name
hdc homolog, cell cycle regulatorprovided by RGD
Primary source
RGD:1304818
See related
EnsemblRapid:ENSRNOG00000060972 AllianceGenome:RGD:1304818
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to be involved in negative regulation of mitotic cell cycle. Predicted to be located in cytoplasm and nucleus. Orthologous to human HECA (hdc homolog, cell cycle regulator). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Spleen (RPKM 148.0), Thymus (RPKM 133.3) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Heca in Genome Data Viewer
Location:
1p12
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (14345306..14395226, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (12525445..12575358, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (13036909..13050644, complement)

Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene developmental pluripotency-associated protein 5A-like Neighboring gene taxilin beta Neighboring gene heat shock protein 90 alpha family class A member 1, pseudogene 2 Neighboring gene ABRA C-terminal like Neighboring gene RALBP1 associated Eps domain containing 1 Neighboring gene epithelial cell transforming 2 like

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. The human HECA interacts with cyclins and CDKs to antagonize Wnt-mediated proliferation and chemoresistance of head and neck cancer cells. Dowejko A, et al. Exp Cell Res, 2012 Mar 10. PMID 22100912
  2. The human homolog of the Drosophila headcase protein slows down cell division of head and neck cancer cells. Dowejko A, et al. Carcinogenesis, 2009 Oct. PMID 19643820
  3. Defining the membrane proteome of NK cells. Ghosh D, et al. J Mass Spectrom, 2010 Jan. PMID 19946888

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Process Evidence Code Pubs
involved_in negative regulation of mitotic cell cycle ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
headcase protein homolog
Names
headcase homolog

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001107514.3 → NP_001100984.2  headcase protein homolog

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000001
    UniProtKB/TrEMBL
    F1M590
    Related
    ENSRNOP00000073877.2, ENSRNOT00000081259.3

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086019.1 Reference GRCr8

    Range
    14345306..14395226 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039112456.2 → XP_038968384.1  headcase protein homolog isoform X3

    Conserved Domains (1) summary
    pfam15353
    Location:93 → 191
    HECA; Headcase protein family homolog

  2. XM_039112451.2 → XP_038968379.1  headcase protein homolog isoform X1

    Conserved Domains (2) summary
    pfam15353
    Location:93 → 191
    HECA; Headcase protein family homolog
    pfam16002
    Location:340 → 401
    Headcase; Headcase protein

  3. XM_063262262.1 → XP_063118332.1  headcase protein homolog isoform X2

RNA

  1. XR_010052133.1 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

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