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Ap3b2 adaptor related protein complex 3 subunit beta 2 [ Rattus norvegicus (Norway rat) ]

Gene ID: 308777, updated on 2-Nov-2024

Summary

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Official Symbol
Ap3b2provided by RGD
Official Full Name
adaptor related protein complex 3 subunit beta 2provided by RGD
Primary source
RGD:1308950
See related
EnsemblRapid:ENSRNOG00000019249 AllianceGenome:RGD:1308950
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to be involved in anterograde synaptic vesicle transport and synaptic vesicle endocytosis. Predicted to be active in presynapse. Human ortholog(s) of this gene implicated in developmental and epileptic encephalopathy 48. Orthologous to human AP3B2 (adaptor related protein complex 3 subunit beta 2). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Brain (RPKM 197.1), Uterus (RPKM 19.9) and 1 other tissue See more
Orthologs
human mouse all
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Genomic context

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See Ap3b2 in Genome Data Viewer
Location:
1q31
Exon count:
27
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (144821819..144854533, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (135412580..135445191, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (143284041..143315846, complement)

Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene cytoplasmic polyadenylation element binding protein 1 Neighboring gene uncharacterized LOC134483747 Neighboring gene uncharacterized LOC134483748 Neighboring gene uncharacterized LOC102555928 Neighboring gene cDNA sequence BC048679-like Neighboring gene small Cajal body-specific RNA 15

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Phosphatidylinositol 4-kinase IIα function at endosomes is regulated by the ubiquitin ligase Itch. Mössinger J, et al. EMBO Rep, 2012 Dec. PMID 23146885, Free PMC Article
  2. The schizophrenia susceptibility factor dysbindin and its associated complex sort cargoes from cell bodies to the synapse. Larimore J, et al. Mol Biol Cell, 2011 Dec. PMID 21998198, Free PMC Article
  3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Process Evidence Code Pubs
involved_in anterograde axonal transport ISO
Inferred from Sequence Orthology
more info
  
involved_in anterograde synaptic vesicle transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in anterograde synaptic vesicle transport ISO
Inferred from Sequence Orthology
more info
  
involved_in synaptic vesicle endocytosis ISO
Inferred from Sequence Orthology
more info
  
involved_in vesicle-mediated transport IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in presynapse ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
AP-3 complex subunit beta-2
Names
adaptor-related protein complex 3, beta 2 subunit

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001107532.2 → NP_001101002.2  AP-3 complex subunit beta-2

    Status: VALIDATED

    Source sequence(s)
    FQ085944, JAXUCZ010000001
    UniProtKB/TrEMBL
    A6JCF9
    Related
    ENSRNOP00000107834.1, ENSRNOT00000026030.9
    Conserved Domains (3) summary
    sd00044
    Location:111 → 139
    HEAT; HEAT repeat [structural motif]
    pfam01602
    Location:34 → 590
    Adaptin_N; Adaptin N terminal region
    pfam14796
    Location:804 → 947
    AP3B1_C; Clathrin-adaptor complex-3 beta-1 subunit C-terminal

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086019.1 Reference GRCr8

    Range
    144821819..144854533 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063262715.1 → XP_063118785.1  AP-3 complex subunit beta-2 isoform X3

  2. XM_063262713.1 → XP_063118783.1  AP-3 complex subunit beta-2 isoform X2

  3. XM_063262712.1 → XP_063118782.1  AP-3 complex subunit beta-2 isoform X1

    Related
    ENSRNOP00000098987.1, ENSRNOT00000159502.1
Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

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