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Prss23 serine protease 23 [ Rattus norvegicus (Norway rat) ]

Gene ID: 308807, updated on 2-Nov-2024

Summary

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Official Symbol
Prss23provided by RGD
Official Full Name
serine protease 23provided by RGD
Primary source
RGD:1359545
See related
EnsemblRapid:ENSRNOG00000017307 AllianceGenome:RGD:1359545
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable serine-type endopeptidase activity. Predicted to be involved in proteolysis. Predicted to be located in nucleus. Orthologous to human PRSS23 (serine protease 23). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Lung (RPKM 564.2), Kidney (RPKM 390.7) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Prss23 in Genome Data Viewer
Location:
1q32
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (152815301..152835005, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (143402725..143422182, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (153732528..153742111, complement)

Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene frizzled class receptor 4 Neighboring gene protein tyrosine phosphatase 4A1, pseudogene 2 Neighboring gene uncharacterized LOC103691188 Neighboring gene uncharacterized LOC102549783 Neighboring gene malic enzyme 3 Neighboring gene uncharacterized LOC120099878

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Extracellular matrix secretion by cardiac fibroblasts: role of microRNA-29b and microRNA-30c. Abonnenc M, et al. Circ Res, 2013 Oct 25. PMID 24006456
  2. Proteomic analysis of human parotid gland exosomes by multidimensional protein identification technology (MudPIT). Gonzalez-Begne M, et al. J Proteome Res, 2009 Mar. PMID 19199708, Free PMC Article
  3. Proteomic analysis of podocyte exosome-enriched fraction from normal human urine. Prunotto M, et al. J Proteomics, 2013 Apr 26. PMID 23376485
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Clone Names

  • MGC94216

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables serine-type endopeptidase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in proteolysis IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
serine protease 23
Names
protease, serine, 23
NP_001007692.1
XP_017444659.1
XP_038969012.1
XP_038969013.1
XP_038969017.1
XP_038969020.1
XP_063118806.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001007691.1 → NP_001007692.1  serine protease 23 precursor

    See identical proteins and their annotated locations for NP_001007692.1

    Status: PROVISIONAL

    Source sequence(s)
    BC079179
    UniProtKB/Swiss-Prot
    Q6AY61
    UniProtKB/TrEMBL
    A0A8I6ALA9, A6I603
    Related
    ENSRNOP00000084133.1, ENSRNOT00000095166.2
    Conserved Domains (1) summary
    cl21584
    Location:147 → 255
    Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086019.1 Reference GRCr8

    Range
    152815301..152835005 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063262736.1 → XP_063118806.1  serine protease 23 isoform X1

    UniProtKB/TrEMBL
    A0A8L2QCB8

  2. XM_017589170.3 → XP_017444659.1  serine protease 23 isoform X1

    UniProtKB/TrEMBL
    A0A8I6ALA9, A0A8L2QCB8
    Conserved Domains (1) summary
    cl21584
    Location:156 → 264
    Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...

  3. XM_039113085.2 → XP_038969013.1  serine protease 23 isoform X2

    UniProtKB/TrEMBL
    A0A8I6ALA9
    Related
    ENSRNOP00000023239.5, ENSRNOT00000023239.6
    Conserved Domains (1) summary
    cl21584
    Location:155 → 263
    Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...

  4. XM_039113089.2 → XP_038969017.1  serine protease 23 isoform X2

    UniProtKB/TrEMBL
    A0A8I6ALA9
    Conserved Domains (1) summary
    cl21584
    Location:155 → 263
    Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...

  5. XM_039113084.2 → XP_038969012.1  serine protease 23 isoform X1

    UniProtKB/TrEMBL
    A0A8I6ALA9, A0A8L2QCB8
    Conserved Domains (1) summary
    cl21584
    Location:156 → 264
    Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...

  6. XM_039113092.2 → XP_038969020.1  serine protease 23 isoform X3

    UniProtKB/Swiss-Prot
    Q6AY61
    UniProtKB/TrEMBL
    A0A8I6ALA9, A6I603
    Related
    ENSRNOP00000089563.2, ENSRNOT00000115268.2
    Conserved Domains (1) summary
    cl21584
    Location:147 → 255
    Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q6AY61.1 GenPept UniProtKB/Swiss-Prot:Q6AY61

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