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Usp35 ubiquitin specific peptidase 35 [ Rattus norvegicus (Norway rat) ]

Gene ID: 308834, updated on 13-Jul-2024

Summary

Official Symbol
Usp35provided by RGD
Official Full Name
ubiquitin specific peptidase 35provided by RGD
Primary source
RGD:1565984
See related
EnsemblRapid:ENSRNOG00000024961 AllianceGenome:RGD:1565984
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
RGD1565984
Summary
Predicted to enable cysteine-type endopeptidase activity and thiol-dependent deubiquitinase. Predicted to be involved in protein deubiquitination. Predicted to be active in cytosol and nucleus. Orthologous to human USP35 (ubiquitin specific peptidase 35). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Testes (RPKM 65.4), Brain (RPKM 37.6) and 8 other tissues See more
Orthologs
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Genomic context

See Usp35 in Genome Data Viewer
Location:
1q32
Exon count:
15
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (161037428..161061114, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (151626195..151649926, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (162283866..162307610, complement)

Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene asparaginyl-tRNA synthetase 2, mitochondrial Neighboring gene uncharacterized LOC108349194 Neighboring gene GRB2-associated binding protein 2 Neighboring gene potassium channel tetramerization domain containing 21 Neighboring gene ALG8, alpha-1,3-glucosyltransferase

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

General gene information

Markers

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables cysteine-type deubiquitinase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables cysteine-type deubiquitinase activity ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
involved_in protein deubiquitination IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in proteolysis IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
 

General protein information

Preferred Names
ubiquitin carboxyl-terminal hydrolase 35
NP_001414738.1
XP_038956997.1
XP_038956999.1
XP_038957000.1
XP_038957001.1
XP_038957002.1
XP_038957003.1
XP_038957004.1
XP_038957007.1
XP_063118829.1
XP_063118830.1
XP_063118837.1
XP_063118838.1
XP_063118839.1
XP_063118842.1
XP_063118843.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001427809.1NP_001414738.1  ubiquitin carboxyl-terminal hydrolase 35

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000001
    UniProtKB/TrEMBL
    F1M8S4
    Related
    ENSRNOP00000038242.5, ENSRNOT00000031161.7

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086019.1 Reference GRCr8

    Range
    161037428..161061114 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039101069.2XP_038956997.1  ubiquitin carboxyl-terminal hydrolase 35 isoform X1

    Conserved Domains (1) summary
    cl02553
    Location:110582
    Peptidase_C19; Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyse bonds involving the carboxyl group of the C-terminal Gly ...
  2. XM_063262773.1XP_063118843.1  ubiquitin carboxyl-terminal hydrolase 35 isoform X3

  3. XM_039101071.2XP_038956999.1  ubiquitin carboxyl-terminal hydrolase 35 isoform X2

    Conserved Domains (1) summary
    cl02553
    Location:46518
    Peptidase_C19; Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyse bonds involving the carboxyl group of the C-terminal Gly ...
  4. XM_063262759.1XP_063118829.1  ubiquitin carboxyl-terminal hydrolase 35 isoform X2

  5. XM_039101076.2XP_038957004.1  ubiquitin carboxyl-terminal hydrolase 35 isoform X3

    Conserved Domains (1) summary
    cl02553
    Location:10482
    Peptidase_C19; Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyse bonds involving the carboxyl group of the C-terminal Gly ...
  6. XM_039101074.2XP_038957002.1  ubiquitin carboxyl-terminal hydrolase 35 isoform X3

    Conserved Domains (1) summary
    cl02553
    Location:10482
    Peptidase_C19; Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyse bonds involving the carboxyl group of the C-terminal Gly ...
  7. XM_063262769.1XP_063118839.1  ubiquitin carboxyl-terminal hydrolase 35 isoform X3

  8. XM_063262772.1XP_063118842.1  ubiquitin carboxyl-terminal hydrolase 35 isoform X3

  9. XM_039101072.2XP_038957000.1  ubiquitin carboxyl-terminal hydrolase 35 isoform X3

    Conserved Domains (1) summary
    cl02553
    Location:10482
    Peptidase_C19; Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyse bonds involving the carboxyl group of the C-terminal Gly ...
  10. XM_063262767.1XP_063118837.1  ubiquitin carboxyl-terminal hydrolase 35 isoform X3

  11. XM_039101079.2XP_038957007.1  ubiquitin carboxyl-terminal hydrolase 35 isoform X3

    Conserved Domains (1) summary
    cl02553
    Location:10482
    Peptidase_C19; Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyse bonds involving the carboxyl group of the C-terminal Gly ...
  12. XM_039101075.2XP_038957003.1  ubiquitin carboxyl-terminal hydrolase 35 isoform X3

    Conserved Domains (1) summary
    cl02553
    Location:10482
    Peptidase_C19; Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyse bonds involving the carboxyl group of the C-terminal Gly ...
  13. XM_063262760.1XP_063118830.1  ubiquitin carboxyl-terminal hydrolase 35 isoform X3

  14. XM_063262768.1XP_063118838.1  ubiquitin carboxyl-terminal hydrolase 35 isoform X3

  15. XM_039101073.2XP_038957001.1  ubiquitin carboxyl-terminal hydrolase 35 isoform X3

    Conserved Domains (1) summary
    cl02553
    Location:10482
    Peptidase_C19; Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyse bonds involving the carboxyl group of the C-terminal Gly ...