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Ints4 integrator complex subunit 4 [ Rattus norvegicus (Norway rat) ]

Gene ID: 308837, updated on 2-Nov-2024

Summary

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Official Symbol
Ints4provided by RGD
Official Full Name
integrator complex subunit 4provided by RGD
Primary source
RGD:1305036
See related
EnsemblRapid:ENSRNOG00000012552 AllianceGenome:RGD:1305036
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
RGD1305036
Summary
Predicted to be involved in snRNA processing. Predicted to be located in nucleolus. Predicted to be part of integrator complex. Orthologous to human INTS4 (integrator complex subunit 4). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Testes (RPKM 122.0), Thymus (RPKM 118.3) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Ints4 in Genome Data Viewer
Location:
1q32
Exon count:
23
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (161201284..161265042)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (151790062..151853827)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (162447692..162511350)

Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene peroxiredoxin 1, pseudogene 2 Neighboring gene potassium channel tetramerization domain containing 14 Neighboring gene adipogenesis associated, Mth938 domain containing Neighboring gene remodeling and spacing factor 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Nuclear-localized Asunder regulates cytoplasmic dynein localization via its role in the integrator complex. Jodoin JN, et al. Mol Biol Cell, 2013 Sep. PMID 23904267, Free PMC Article
  2. Integrator, a multiprotein mediator of small nuclear RNA processing, associates with the C-terminal repeat of RNA polymerase II. Baillat D, et al. Cell, 2005 Oct 21. PMID 16239144
  3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Process Evidence Code Pubs
involved_in snRNA processing IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in snRNA processing ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
part_of integrator complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of integrator complex ISO
Inferred from Sequence Orthology
more info
  
located_in nucleolus IEA
Inferred from Electronic Annotation
more info
  
located_in nucleolus ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
integrator complex subunit 4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001191629.1 → NP_001178558.1  integrator complex subunit 4

    Status: PROVISIONAL

    Source sequence(s)
    JAXUCZ010000001
    UniProtKB/TrEMBL
    A0A8I6ATK0, D3ZZQ6
    Related
    ENSRNOP00000016770.5, ENSRNOT00000016770.8
    Conserved Domains (3) summary
    COG1413
    Location:52 → 257
    HEAT; HEAT repeat [General function prediction only]
    pfam12755
    Location:199 → 256
    Vac14_Fab1_bd; Vacuolar 14 Fab1-binding region
    sd00044
    Location:200 → 222
    HEAT; HEAT repeat [structural motif]

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086019.1 Reference GRCr8

    Range
    161201284..161265042
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063262797.1 → XP_063118867.1  integrator complex subunit 4 isoform X1

Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

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