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Fchsd2 FCH and double SH3 domains 2 [ Rattus norvegicus (Norway rat) ]

Gene ID: 308864, updated on 2-Nov-2024

Summary

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Official Symbol
Fchsd2provided by RGD
Official Full Name
FCH and double SH3 domains 2provided by RGD
Primary source
RGD:1304812
See related
EnsemblRapid:ENSRNOG00000019319 AllianceGenome:RGD:1304812
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable phosphatidylinositol-3,4,5-trisphosphate binding activity and phosphatidylinositol-3,4-bisphosphate binding activity. Predicted to be involved in several processes, including clathrin-dependent endocytosis; neuromuscular synaptic transmission; and positive regulation of supramolecular fiber organization. Predicted to be located in clathrin-coated pit; plasma membrane; and stereocilium shaft. Predicted to be active in neuromuscular junction and recycling endosome. Orthologous to human FCHSD2 (FCH and double SH3 domains 2). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Spleen (RPKM 166.1), Thymus (RPKM 128.6) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Fchsd2 in Genome Data Viewer
Location:
1q32
Exon count:
28
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (164775916..165097391)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (155444471..155685350)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (166140025..166395915)

Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene Rho guanine nucleotide exchange factor 17 Neighboring gene microRNA 3102 Neighboring gene pyrimidinergic receptor P2Y6 Neighboring gene purinergic receptor P2Y2 Neighboring gene uncharacterized LOC120097346 Neighboring gene ribosomal protein L7a, pseudogene 36 Neighboring gene autophagy related 16-like 2 Neighboring gene StAR-related lipid transfer domain containing 10

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. A Flat BAR Protein Promotes Actin Polymerization at the Base of Clathrin-Coated Pits. Almeida-Souza L, et al. Cell, 2018 Jul 12. PMID 29887380, Free PMC Article
  2. Formation of membrane ridges and scallops by the F-BAR protein Nervous Wreck. Becalska AN, et al. Mol Biol Cell, 2013 Aug. PMID 23761074, Free PMC Article
  3. FCHSD1 and FCHSD2 are expressed in hair cell stereocilia and cuticular plate and regulate actin polymerization in vitro. Cao H, et al. PLoS One, 2013. PMID 23437151, Free PMC Article
  4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables phosphatidylinositol-3,4,5-trisphosphate binding ISO
Inferred from Sequence Orthology
more info
  
enables phosphatidylinositol-3,4-bisphosphate binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in clathrin-dependent endocytosis ISO
Inferred from Sequence Orthology
more info
  
involved_in membrane organization ISO
Inferred from Sequence Orthology
more info
  
involved_in neuromuscular synaptic transmission IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of Arp2/3 complex-mediated actin nucleation ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of actin filament polymerization ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of actin filament polymerization IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in clathrin-coated pit ISO
Inferred from Sequence Orthology
more info
  
is_active_in neuromuscular junction IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  
is_active_in recycling endosome IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in stereocilium shaft ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
F-BAR and double SH3 domains protein 2
Names
FCH and double SH3 domains protein 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001395742.1 → NP_001382671.1  F-BAR and double SH3 domains protein 2

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000001
    UniProtKB/TrEMBL
    A0A8I6G358, D3ZCY3
    Related
    ENSRNOP00000079354.1, ENSRNOT00000113808.2
    Conserved Domains (3) summary
    cd07677
    Location:16 → 275
    F-BAR_FCHSD2; The F-BAR (FES-CIP4 Homology and Bin/Amphiphysin/Rvs) domain of FCH and double SH3 domains 2 (FCHSD2)
    cd11761
    Location:471 → 527
    SH3_FCHSD_1; First Src Homology 3 domain of FCH and double SH3 domains proteins
    cd11894
    Location:571 → 626
    SH3_FCHSD2_2; Second Src Homology 3 domain of FCH and double SH3 domains protein 2

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086019.1 Reference GRCr8

    Range
    164775916..165097391
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063262815.1 → XP_063118885.1  F-BAR and double SH3 domains protein 2 isoform X2

    Related
    ENSRNOP00000048024.5, ENSRNOT00000042524.6

  2. XM_063262816.1 → XP_063118886.1  F-BAR and double SH3 domains protein 2 isoform X2

  3. XM_008759721.4 → XP_008757943.2  F-BAR and double SH3 domains protein 2 isoform X1

    UniProtKB/TrEMBL
    A0A0G2K219, D3ZCY3
    Related
    ENSRNOP00000072072.2, ENSRNOT00000091822.3
    Conserved Domains (3) summary
    cd07677
    Location:16 → 275
    F-BAR_FCHSD2; The F-BAR (FES-CIP4 Homology and Bin/Amphiphysin/Rvs) domain of FCH and double SH3 domains 2 (FCHSD2)
    cd11761
    Location:495 → 551
    SH3_FCHSD_1; First Src Homology 3 domain of FCH and double SH3 domains proteins
    cd11894
    Location:595 → 650
    SH3_FCHSD2_2; Second Src Homology 3 domain of FCH and double SH3 domains protein 2

  4. XM_063262817.1 → XP_063118887.1  F-BAR and double SH3 domains protein 2 isoform X3

RNA

  1. XR_005506100.2 RNA Sequence

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001107539.1: Suppressed sequence

    Description
    NM_001107539.1: This RefSeq was removed because currently there is insufficient support for the transcript and the protein.
Nucleotide Protein Strain
Heading Accession and Version

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