Irag1 inositol 1,4,5-triphosphate receptor associated 1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Irag1provided by RGD
Official Full Name: inositol 1,4,5-triphosphate receptor associated 1provided by RGD
Primary source: RGD:1309828
See related: EnsemblRapid:ENSRNOG00000017767 AllianceGenome:RGD:1309828
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Mrvi1
Summary: This gene is similar to a putative mouse tumor suppressor gene that is frequently disrupted by mouse AIDS-related virus (MRV). The encoded protein, which is found in the membrane of the endoplasmic reticulum, is similar to Jaw1, a lymphoid-restricted protein whose expression is down-regulated during lymphoid differentiation. Studies in mouse suggest that MRV integration at the homologous mouse gene induces myeloid leukemia by altering the expression of a gene important for myeloid cell growth and/or differentiation, and thus this gene may function as a myeloid leukemia tumor suppressor gene. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Nov 2013]
Expression: Biased expression in Uterus (RPKM 126.4), Heart (RPKM 41.0) and 7 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 1q33

Exon count:: 22

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	1	NC_086019.1 (174416383..174528913, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	1	NC_051336.1 (164981716..165094232, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	1	NC_005100.4 (175681960..175804737, complement)

Chromosome 1 - NC_086019.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Demonstrates alternative splicing in the similar mouse and human genes, and the use of a non-AUG (CUG) translation initiation codon in one of the transcript variants.
Title: Mrvi1, a common MRV integration site in BXH2 myeloid leukemias, encodes a protein with homology to a lymphoid-restricted membrane protein Jaw1.
Functional analysis of a similar gene in mouse.
Title: IRAG is essential for relaxation of receptor-triggered smooth muscle contraction by cGMP kinase.

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General gene information

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Markers

RH140771 (e-PCR)
- UniSTS:222837

AU048693 (e-PCR)
- UniSTS:145143

Gene Ontology Provided by RGD

Process	Evidence Code	Pubs
involved_in cGMP-mediated signaling	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within cGMP-mediated signaling	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within negative regulation of smooth muscle contraction	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within relaxation of vascular associated smooth muscle	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: inositol 1,4,5-triphosphate receptor associated 1

Names: MRV integration site 1 homolog; murine retrovirus integration site 1 homolog; protein MRVI1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001105210.1 → NP_001098680.1 inositol 1,4,5-triphosphate receptor associated 1 isoform b

See identical proteins and their annotated locations for NP_001098680.1

Status: REVIEWED

Description

Transcript Variant: This variant (2) contains an additional 5' exon, is differently spliced at the initial coding exon, and initiates translation from an in-frame, downstream AUG compared to variant 1. The resulting isoform (b) has a shorter N-terminus compared to isoform a.

Source sequence(s)

CH473956

UniProtKB/TrEMBL

A0A8I6A064, A6I830, D3ZDF3

Related

ENSRNOP00000024060.5, ENSRNOT00000024060.7

Conserved Domains (1) summary

pfam05781
Location:272 → 855

MRVI1; MRVI1 protein
NM_001105211.1 → NP_001098681.1 inositol 1,4,5-triphosphate receptor associated 1 isoform a

See identical proteins and their annotated locations for NP_001098681.1

Status: REVIEWED

Description

Transcript Variant: This variant (1) encodes the longer isoform (a).

Source sequence(s)

CH473956

UniProtKB/TrEMBL

A0A8I6A064, A6I829

Related

ENSRNOP00000084718.2, ENSRNOT00000107498.2

Conserved Domains (1) summary

pfam05781
Location:337 → 920

MRVI1; MRVI1 protein