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Ppfibp2 PPFIA binding protein 2 [ Rattus norvegicus (Norway rat) ]

Gene ID: 308918, updated on 2-Nov-2024

Summary

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Official Symbol
Ppfibp2provided by RGD
Official Full Name
PPFIA binding protein 2provided by RGD
Primary source
RGD:1565383
See related
EnsemblRapid:ENSRNOG00000019667 AllianceGenome:RGD:1565383
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable identical protein binding activity. Predicted to be involved in neuromuscular junction development. Is active in presynapse. Orthologous to human PPFIBP2 (PPFIA binding protein 2). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Liver (RPKM 91.6), Lung (RPKM 80.4) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Ppfibp2 in Genome Data Viewer
Location:
1q33
Exon count:
24
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (170916649..171062096)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (161504774..161687339)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (171816231..171969117)

Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134485161 Neighboring gene olfactomedin-like 1 Neighboring gene cytochrome b5 reductase 2 Neighboring gene carnitine deficiency-associated gene expressed in ventricle 3 like 1 Neighboring gene ovochymase 2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Crystal structure of the central coiled-coil domain from human liprin-β2. Stafford RL, et al. Biochemistry, 2011 May 10. PMID 21462929, Free PMC Article
  2. Molecular profiling of synaptic vesicle docking sites reveals novel proteins but few differences between glutamatergic and GABAergic synapses. Boyken J, et al. Neuron, 2013 Apr 24. PMID 23622064
  3. Comparison of tear protein levels in breast cancer patients and healthy controls using a de novo proteomic approach. Böhm D, et al. Oncol Rep, 2012 Aug. PMID 22664934, Free PMC Article
  4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in neuromuscular junction development IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in presynapse EXP
Inferred from Experiment
more info
 PubMed 
is_active_in presynapse IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in presynaptic active zone IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
liprin-beta-2
Names
PTPRF interacting protein, binding protein 2 (liprin beta 2)
liprin beta 2
protein tyrosine phosphatase, receptor-type, F interacting protein, binding protein 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001100582.1 → NP_001094052.1  liprin-beta-2

    See identical proteins and their annotated locations for NP_001094052.1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000001
    UniProtKB/TrEMBL
    A6I7S0, A6I7S1
    Related
    ENSRNOP00000047694.4, ENSRNOT00000047831.4
    Conserved Domains (6) summary
    cd09563
    Location:555 → 618
    SAM_liprin-beta1,2_repeat1; SAM domain of liprin-beta1,2 proteins repeat 1
    cd09566
    Location:629 → 691
    SAM_liprin-beta1,2_repeat2; SAM domain of liprin-beta1,2 proteins repeat 2
    cd09569
    Location:714 → 785
    SAM_liprin-beta1,2_repeat3; SAM domain of liprin-beta proteins repeat 3
    smart00454
    Location:555 → 619
    SAM; Sterile alpha motif
    pfam01519
    Location:110 → 161
    DUF16; Protein of unknown function DUF16
    cl23720
    Location:211 → 308
    RILP-like; Rab interacting lysosomal protein-like 1 and 2 (Rilpl1 and Rilpl2)

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086019.1 Reference GRCr8

    Range
    170916649..171062096
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

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