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Wee1 WEE1 G2 checkpoint kinase [ Rattus norvegicus (Norway rat) ]

Gene ID: 308937, updated on 18-Sep-2024

Summary

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Official Symbol
Wee1provided by RGD
Official Full Name
WEE1 G2 checkpoint kinaseprovided by RGD
Primary source
RGD:1307895
See related
EnsemblRapid:ENSRNOG00000010017 AllianceGenome:RGD:1307895
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable protein tyrosine kinase activity. Predicted to be involved in cell division and mitotic cell cycle. Predicted to act upstream of or within several processes, including establishment of cell polarity; neuron projection morphogenesis; and peptidyl-tyrosine phosphorylation. Predicted to be located in cytoplasm and nucleolus. Predicted to be active in nucleus. Orthologous to human WEE1 (WEE1 G2 checkpoint kinase). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Testes (RPKM 65.2), Thymus (RPKM 58.0) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Wee1 in Genome Data Viewer
Location:
1q33
Exon count:
14
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (173605609..173632450)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (164173681..164197688)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (174765228..174790882)

Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene importin 7 Neighboring gene small nucleolar RNA, H/ACA box 23 Neighboring gene uncharacterized LOC134483773 Neighboring gene zinc finger protein 143 Neighboring gene RNA, U6 small nuclear 1168 Neighboring gene switching B-cell complex subunit SWAP70 Neighboring gene SET binding factor 2 Neighboring gene N-lysine methyltransferase KMT5A-like Neighboring gene Y box binding protein 1, pseudogene 18

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Temporal gradient in the clock gene and cell-cycle checkpoint kinase Wee1 expression along the gut. Polidarová L, et al. Chronobiol Int, 2009 May. PMID 19444744
  2. Correlation of Myc Expression with Wee1 Expression by Zanthoxylum acanthopodium in Cervical Carcinoma Histology. Ilyas S, et al. Pak J Biol Sci, 2022 Jan. PMID 36591933
  3. Maturation promoting factor destabilization facilitates postovulatory aging-mediated abortive spontaneous egg activation in rat. Prasad S, et al. Dev Growth Differ, 2016 Apr. PMID 26991553
  4. Expression of wee1 and its related cell cycle components in mouse early stage follicles. Park CE, et al. Cells Tissues Organs, 2004. PMID 15459478
  5. Mouse p87wee1 kinase is regulated by M-phase specific phosphorylation. Honda R, et al. Chromosome Res, 1995 Aug. PMID 7551544

See all (9) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Correlation of Myc Expression with Wee1 Expression by Zanthoxylum acanthopodium in Cervical Carcinoma Histology.
    Title: Correlation of Myc Expression with Wee1 Expression by Zanthoxylum acanthopodium in Cervical Carcinoma Histology.
  2. Data suggest that the increase of Wee 1 tyrosine kinase but decrease of early mitotic inhibitor 2 level triggers maturation promoting factor (MPF) destabilization and thereby postovulatory aging-mediated abortive spontaneous egg activation in eggs.
    Title: Maturation promoting factor destabilization facilitates postovulatory aging-mediated abortive spontaneous egg activation in rat.
  3. identified the PI3K/Akt pathway, the cell-cycle regulator Wee1 kinase, and protein kinase C (PKC) as prospective regulatory nodes of neuronal excitability through modulation of the FGF14:Nav1.6 complex.
    Title: Identifying a kinase network regulating FGF14:Nav1.6 complex assembly using split-luciferase complementation.
  4. The regulation of Wee1 by SadA and SadB kinases is essential for the differentiation of polarized neurons.
    Title: Persistence of the cell-cycle checkpoint kinase Wee1 in SadA- and SadB-deficient neurons disrupts neuronal polarity.
  5. rhythmic profiles of the clock gene Wee1 expression within the epithelium from different parts of the rat gut exhibited a difference in phasing.
    Title: Temporal gradient in the clock gene and cell-cycle checkpoint kinase Wee1 expression along the gut.
Submit: New GeneRIF Correction

Pathways from PubChem

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General gene information

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Markers

Homology

Clone Names

  • MGC105683

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables magnesium ion binding IEA
Inferred from Electronic Annotation
more info
  
enables non-membrane spanning protein tyrosine kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein kinase activity ISO
Inferred from Sequence Orthology
more info
  
enables protein tyrosine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein tyrosine kinase activity ISO
Inferred from Sequence Orthology
more info
  
enables protein tyrosine kinase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
Process Evidence Code Pubs
involved_in cell division IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within establishment of cell polarity ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within microtubule cytoskeleton organization ISO
Inferred from Sequence Orthology
more info
  
involved_in mitotic cell cycle IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of G2/M transition of mitotic cell cycle IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in negative regulation of G2/M transition of mitotic cell cycle ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of G2/M transition of mitotic cell cycle ISS
Inferred from Sequence or Structural Similarity
more info
  
acts_upstream_of_or_within neuron projection morphogenesis ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within peptidyl-tyrosine phosphorylation ISO
Inferred from Sequence Orthology
more info
  
involved_in protein phosphorylation IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within protein phosphorylation ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in nucleolus IEA
Inferred from Electronic Annotation
more info
  
located_in nucleolus ISO
Inferred from Sequence Orthology
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  
is_active_in nucleus ISO
Inferred from Sequence Orthology
more info
  
is_active_in nucleus ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
wee1-like protein kinase
Names
wee 1 homolog
wee1 tyrosine kinase
wee1A kinase
NP_001012760.1
XP_006230036.1
XP_017444692.1
XP_063119123.1
XP_063119130.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001012742.1 → NP_001012760.1  wee1-like protein kinase

    See identical proteins and their annotated locations for NP_001012760.1

    Status: PROVISIONAL

    Source sequence(s)
    BC090346
    UniProtKB/Swiss-Prot
    Q5EAN3, Q63802
    UniProtKB/TrEMBL
    A6I810
    Related
    ENSRNOP00000013362.3, ENSRNOT00000013362.7
    Conserved Domains (1) summary
    cd14138
    Location:292 → 567
    PTKc_Wee1a; Catalytic domain of the Protein Tyrosine Kinase, Wee1a

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086019.1 Reference GRCr8

    Range
    173605609..173632450
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006229974.5 → XP_006230036.1  wee1-like protein kinase isoform X2

    UniProtKB/TrEMBL
    A0A8I5ZT95
    Related
    ENSRNOP00000081602.1, ENSRNOT00000118795.2
    Conserved Domains (2) summary
    cd14138
    Location:292 → 567
    PTKc_Wee1a; Catalytic domain of the Protein Tyrosine Kinase, Wee1a
    pfam00069
    Location:298 → 568
    Pkinase; Protein kinase domain

  2. XM_063263053.1 → XP_063119123.1  wee1-like protein kinase isoform X1

    UniProtKB/Swiss-Prot
    Q5EAN3, Q63802
    UniProtKB/TrEMBL
    A6I810

  3. XM_063263060.1 → XP_063119130.1  wee1-like protein kinase isoform X3

  4. XM_017589203.3 → XP_017444692.1  wee1-like protein kinase isoform X3

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q63802.1 GenPept UniProtKB/Swiss-Prot:Q63802

Gene LinkOut

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